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Biomedical subjects

I Stamenkovic

Publications and source records attributed to I Stamenkovic.

99 records · Page 6Linked to original sources
PubMed1984

Early recognition of potentially fatal necrotizing fasciitis. The use of frozen-section biopsy.

Necrotizing fasciitis is a rare, rapidly progressing soft-tissue infection. Early clinical recognition is difficult, and there is often a fatal delay in appropriate treatment. We evaluated the use of frozen-section biopsies for the rapid diagnosis of this disease in its early stages. Nineteen cases of necrotizing fasciitis were studied over a 13-year period. In all eight cases in which frozen-section biopsy was performed within zero to four days (average, 21 hours) after the onset of symptoms, histologic study confirmed the diagnosis, and surgical d ebridement was immediately performed. Only one patient died. In 11 patients, the diagnosis was made on clinical grounds, and surgical therapy was delayed for 1 to 15 days (average, 6) after the onset of symptoms because of failure to recognize the disorder immediately. Eight patients died (P less than 0.02). Our study indicates that rapid performance of frozen-section soft-tissue biopsy early in the evolution of a suspect lesion may provide a definitive and life-saving diagnosis.

Adult↗
PubMed1983

[Periarteritis nodosa: clinical presentation limited to severe kidney failure accompanied by arterial hypertension].

Two cases of severe renal failure and hypertension of a few weeks duration are reported. There were no symptoms nor signs suggestive of extra-renal involvement and the laboratory tests, more specifically those for the detection of inflammatory parameters, were normal. Renal angiograms revealed intraparenchymal arterial microaneuvrysms which led to the diagnosis of vasculitis of the periarteritis nodosa type. Combined immunosuppressive and steroid treatment was successful in both cases regarding blood pressure control and improvement of renal function. The importance of renal angiography as a diagnostic tool in this type of clinical setting is underlined, as well as the necessity for prompt and prolonged immunosuppressive therapy.

Adult↗
PubMed1982

[Long-term survival after 1 or more recurrences of Hodgkin's lymphomas].

It is generally accepted that the prognosis in relapsing Hodgkin's disease is poor, and the literature contains few reports of cases that have involved one or more relapses and been cured. The evolution in 14 patients who suffered at least one relapse after initial complete remission is studied with respect to staging, histology, type of induction treatment, duration of complete remission, mode of relapse, type of retreatment and length of survival. Long term survival is reported despite one or more relapses, and it is concluded that relapsing Hodgkin's disease can be cured irrespective of the extension of the disease. The importance of an aggressive therapeutic approach in these cases is stressed.

Adolescent↗
PubMed1982

[Isolated renal involvement in periarteritis nodosa].

Periarteritis nodosa (PAN) is a disease involving the kidneys in 70% of cases but always affecting other organs. Initial presentation with acute renal failure (ARF) and high blood pressure (HBP) is unusual. In two patients presenting those two features without any clinical or biochemical signs of other organ involvements, diagnosis of PAN was based on the presence of microaneurysms on renal angiograms. Combined immunosuppressive and steroid treatment resulted in control of blood pressure of both patients and improvement of renal function in one. ARF associated with HBP without evidence of other organ involvements is consistent with the diagnosis of PAN. In this clinical setting, renal angiography should be performed to confirm the diagnosis and establish the appropriate therapy.

Acute Kidney Injury↗
PubMed1981

Polymorphic reticulosis (lethal midline granuloma) and lymphomatoid granulomatosis: identical or distinct entities?

Two cases of polymorphic reticulosis were studied. Both cases had a fatal clinical course, that of the second case being rapid and progressive and ending 6 months after the onset of the disease with little demonstrable effect of steroid therapy. Biopsy material was obtained in both patients, and both were submitted to a post-mortem examination. The first case showed typical angiocentric, angiodestructive, polymorphous lymphoreticular infiltrates, involving the pharyngeal region and the tongue. The second case demonstrated these same lesions in the midfacial region, the lungs and the skin. A possible identify between polymorphic reticulosis and lymphomatoid granulomatosis is discussed (because of the coexistence of identical lesions in the midfacial region and in the lung parenchyma in the second case). Wegener's granulomatosis in limited and disseminated forms and malignant lymphoma are considered in the differential diagnosis.

Adult↗