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Biomedical subjects

I Sonkoly

Publications and source records attributed to I Sonkoly.

At least 37 records · Page 2Linked to original sources
PubMed1983

Studies on the lymphocyte subpopulation in systemic lupus erythematosus by monoclonal antibodies.

T cells and T-cell subsets were studied with monoclonal antibodies in 15 patients with systemic lupus erythematosus (SLE) during a 6-wk period. During active states of disease, all investigated T-cell subsets decreased, but the reduction of suppressor cells seemed to be more pronounced, therefore the helper/suppressor ratio increased. Less suppressor cells could be detected during clinical impairments and more during improvements.

Adult↗
PubMed1983

Signals of monocyte activation in patients with SLE.

The Fc receptor mediated reaction, the beta-glucuronidase and the lactic dehydrogenase activities of monocytes and the serum lysozyme level were tested together with the circulating immune complex content of patients with systemic lupus erythematosus. Simultaneously with the increasing FC receptor-mediated reaction and the elevated enzyme activities of patient monocytes, the secretion of lysozyme and the immune complex content of the sera were higher than those of the controls. A positive correlation was demonstrated between the Fc receptor-mediated reaction, the beta-glucuronidase activity, the lysozyme secretion and the immune complex content of the sera. Thus, the monocytes of patients appeared to be activated by the circulating immune complexes.

Antigen-Antibody Complex↗
PubMed1982

Monocyte activation by immune complexes of patients with SLE.

1. IC precipitated by PEG from patients with SLE inhibit in vitro the FcR dependent reaction of normal monocytes with sSRBC, while the C3bR dependent reaction of the cells with sensitized yeast is reduced only by some of them. The monocytes were preincubated with the IC for 30 min at room temperature. 2. When the monocytes were incubated with the IC for 22 hours at 37 degrees C the reaction of FcR with sSRBC increased, while the C3bR dependent reaction did not altered. 3. Simultaneously with the increasing FcR dependent reaction, the secretion of lysosomal beta-glucuronidase of monocytes cultivated with IC is greater than those of the controls.

Antigen-Antibody Complex↗
PubMed1982

Enzyme-linked immunosorbent assay for antibodies to native DNA in sera of patients with SLE.

A micro-ELISA technique has been developed to measure antibodies to native DNA and used in SLE patients. The distribution of antibody to native DNA in the main immunoglobulin classes was studied, using anti-human globulin conjugates labelled with peroxidase. the antigen (double-stranded DNA from calf thymus) used in the assay was adsorbed to the surface of polystyrene plates treated with methylated bovine serum albumin. The standardization of the method was carried out by use of globulin calibration curves.

Adsorption↗
PubMed1980

Immunological investigations in acute and chronic human pancreatitis.

Follow-up immunological studies in 27 patients with acute pancreatitis of known etiology showed a significant elevation in the level of circulating immune complexes (IC), a significant inhibition in migration of leukocytes (with direct LMT) of patients and a significant decrease in the percentage of T-active, T-total peripheral lymphocytes and in the absolute count of peripheral T cells. Elevated circulating IC levels could been detected 3-4 weeks after the onset of acute pancreatitis. These immunological changes have still been demonstrated in a number of patients 7-14 months after recovery. We have found similar immunological alterations in patients with chronic pancreatitis as well. The possible causes and role of these long-term existing immunologic abnormalities are discussed.

Adult↗
PubMed1980

Loss of monocyte membrane receptors in patients with SLE.

Following an 80-min cold treatment of monocytes and their subsequent heating at 37 degrees C a part of the Fc and C3 receptors is shed from the cells into the serum-free medium. However, while the reduced expression of cell membrane Fc receptors is regenerated at 37 degrees C in 4-8 hr, that of the C3 receptors is not. Initially, the Fc receptor expression of monocytes for patients with SLE is greater than that of controls and after shedding it increases to the level of controls at 37 degrees C in 4-8 hr. The expression and the regeneration of C3 receptors are equivalent to those of controls. The phagocytic ability of patient monocytes is lower than that of controls and the difference also remains after heat treatment.

Female↗
PubMed1979

Circulating immune complexes and monocyte Fc function in autoimmune diseases.

The phagocytosis of separated and adherent monocytes of patients with systemic lupus erythematosus is subnormal as compared to controls on the basis of latex and yeast uptake. The monocytes from the same patients react with antibody-coated sheep red blood cells in a significantly higher degree than normal monocytes. There is a correlation between the percentage of reactive monocytes and the serum immune complex content. After brief treatment of patients with levamisole the phagocytic function of monocytes is restored and at the same time the circulating immune complex content is decreased.

Antigen-Antibody Complex↗
PubMed1979

Histamine-binding receptors and Fc receptors of T lymphocytes in SLE.

The participation of TG cells forming the suppressor T cell population and of histamine-binding cells was determined in the peripheral blood of patients with SLE. Former was considerably diminished in the active phase of the disease, latter was found diminished in both the active and the inactive phase. The results published in this paper support the functional disorder of suppressor T cells in SLE, an assumption based only on sporadic data before.

Female↗
PubMed1979

T and B lymphocytes in lymph nodes and spleen of patients with Hodgkin's disease.

Lymphocyte surface markers of 100 tissue specimens (67 lymph nodes and 33 spleens) of 40 patients with Hodgkin's disease were studied by means of spontaneous E-rosette formation and direct immunofluorescence method. The occurrence of active and total T cells was signigicantly higher (p less than 0.001) in the tumor-involved lymph nodes and spleens, while the frequency of B cells was practically the same in the histologically negative lymph nodes and spleens. In the tumorous spleen of 6 untreated patients the frequency of active and total T cells was higher in the tumorous tissue specimens than in the surrounding histologically negative tissue specimens. No correlation has been found between the simultaneously investigated peripheral T and B cell counts, clinical stage and the histological type of the tumor.

B-Lymphocytes↗
PubMed1978

Progressive vaccinia: immunological aspects and transfer factor therapy.

Progressive vaccinia is a rare and serious complication of smallpox vaccination. Depressed immune function can generally be found as an underlying disorder; thus adequate immuno-correction may be expected to be therapeutically effective. Humoral and cell-mediated immunity was repeatedly examined in one case throughout the course of the disease. Results indicated partial deficiency of cell-mediated immunity. No therapeutic effect was achieved by using human antivaccinia immunoglobulin and N-methylisatin beta-thiosemicarbazone. Transfer factor therapy was also attempted. Treatment with a non-specific transfer factor preparation was followed by a transitory clinical improvement. A specific transfer factor preparation given during the last month of life, however, had no therapeutic effect. The patient died on the 145th day after vaccination. Autopsy findings pointed to combined immune deficiency.

Humans↗
PubMed1978

Antibody dependent cellular cytotoxicity of lymphocytes in patients with renal diseases of immunopathological origin.

Antibody dependent cytotoxicity (ADCC) of lymphocytes from twenty-two patients with histologically proven chronic glomerulonephritis and eight patients with SLE nephropathy was studied in a xenogeneic assay on chicken red blood cells and in an allogeneic test system using Rh(+) human erythrocyte targets. ADCC activity of the lymphocytes of patients with chronic glomerulonephritis did not differ from that of normals, while all patients with SLE nephropathy showed significantly lower cytotoxicity than healthy controls. The possible role ADCC in the pathogenesis of renal diseases of immunopathological origin is discussed.

Adult↗
PubMed1977

Antibody-dependent cellular cytotoxicity in systemic lupus erythematosus.

Antibody-dependent cellular cytotoxicity of peripheral blood mononuclear cells from fourty-six patients with systemic lupus erythematosus was found to be reduced in two independent test systems. The percentage decrease in cytotoxicity was similar in the tests with allogeneic and xenogeneic targets and it was related to the activity of systemic lupus erythematosus.

Adult↗
PubMed1977

[Nephropathy associated with systemic lupus erythematosus].

The investigation of needle- kidney biopsy from patients with SLE- nephrotic syndrome was carried out by the aid of light- immunofluorescent- and electron microscopy. Membranous-, focal-proliferative-, and diffuse-proliferative forms of the SLE- nephrotic syndrome were distinguished. Clinical characteristics of the different forms are described. Authors believe, that the underlying process of nephrological symptoms of various degree as well as readily distinguishable clinico-pathological pictures is the formation of circulating immunocomplexes of different size, developing due to basic disease itself. Comparison of the clinical symptoms and the morphological picture indicate that the elapse of time between the onset of the underlying disease and the nephrotic syndrome has an important part in the formation of the SLE-nephropathy of focal- and diffuse-proliferative type.

Adolescent↗
PubMed1976

Studies on T and B lymphocytes in the peripheral blood of discoid lupus erythematosus patients with and without chloroquine treatment.

The proportions of T-B cells of peripheral lymphocytes in DLE patients as well as the effect of chloroquine treatment on T cell count were studied. In DLE, both the active and the total rosette-forming cell counts decreased, whereas the B cell count did not differ from normal values. Long-term chloroquine administration causes a further reduction in T cell count.

B-Lymphocytes↗