Biomedical subjects
I Sommer
Publications and source records attributed to I Sommer.
[Simultaneous light and thermo-electric recording of changes in eye and frontal-lobe blood flow in the cat].
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[Treatment of common diseases of caged and aviary birds, in particular the budgerigar].
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[Clinical aspects of distemper in dogs (Febris contagiosa canum)].
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[Contribution to E. Kunzel's article "Criteria for admission and 1st results of treatment"].
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Primary psoas abscess three years after ipsilateral nephrectomy.
We report an unusual case of primary, right psoas abscess caused by Proteus mirabilis which developed three years after ipsilateral nephrectomy. The diagnosis was established by computer tomography, recommended today as superior to other diagnostic methods of demonstration for the retroperitoneum.
A rare presentation of systemic salmonellosis.
We are reporting an unusual case of disseminated Salmonella enteritidis D, phage group E2 infection in an 18-year-old male, which was resistant to massive antibiotic treatment. Rare complications such as pylephlebitis, mediastinal adenopathy, osteomyelitis with pathological clavicular fracture, osteitis and spondylitis were observed. We found an immunological defect that no doubt contributed to this severe illness.
Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1.
Cell surface molecules have been implicated in cell interactions which underlie formation of the nervous system. The analysis of the functional properties of such molecules has profited from the combined use of antibodies and cell culture systems. It has been suggested that the interplay between these molecules modulates cell-to-cell interaction at critical developmental stages. In the mouse, N-CAM and L1 antigen have been shown to mediate Ca2+-independent adhesion among neural cells. N-CAM plays a role in fasciculation of neurites and formation of neuromuscular junction. L1 is apparently not involved in synaptogenesis, but in migration of granule cell neurones in the developing mouse cerebellar cortex. The two antigens are distinct molecular and functional entities which act synergistically in aggregation of neuroblastoma and early postnatal cerebellar cells. In view of a certain similarity in function between the two groups of molecules, it was not surprising to find that structural similarities are detectable by the monoclonal antibody L2. We show here that a carbohydrate moiety recognized by L2 and HNK-1 monoclonal antibodies, is present in mouse N-CAM and L1. The L2 epitope appears on all major neural cell types but not all N-CAM molecules express it. This heterogeneity points to a previously undetected molecular diversity which may have functional implications for modulating cell adhesion during development.
Geniom technology--the benchtop array facility.
Febit AG develops an integrated benchtop instrument for in situ microarrays preparation, hybridization, readout and data analysis.
[Treatment of chronic constipation in a small child. Report of cases with reference to the literature on chronic constipation].
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Density-dependent growth adaptation kinetics in 3T3 cell populations following sudden [Ca2+] and temperature changes. A comparison with SV40-3T3 cells.
Lowered extracellular [Ca2+] cause low growth rates and low stationary cell densities in 3T3 cell cultures as compared to physiological [Ca2%]. Under otherwise constant conditions the extracellular [Ca2+] determines a stable stationary cell density, which can be reached by increase of net cell number or decrease of net cell number, depending on cell density at the time of [Ca2+] adjustment. SV40-3T3 cells do not show this [Ca2+] dependency. At 39 degrees C 3T3 and SV40-3T3 cell populations show an increased growth rate at low cell densities as compared to cell populations at 35 degrees C. Approaching the stationary density the growth rate of both cell sorts is reduced faster at 39 degrees C than at 35 degrees C, leading to lower stationary cell densities at 39 degrees C than at 35 degrees C. A temperature change from 39 degrees C to 35 degrees C or in the opposite direction can affect the stationary cell density of 3T3 cell populations only if applied before reduction of growth rate by density-dependent growth-inhibiting principles has taken place.
[Differential diagnosis of presenile dementia from the neurological viewpoint].
The author shows that dementia does not exist as a disease as such. Therefore, efforts in terms of differential diagnostics are required to investigate this psychopathological syndrome which may conceal a number of clinical pictures which are easy to treat or manifest themselves as dementia. If a patient suffers from dementia, the physician must not give in to diagnostic and therapeutical nihilism. Diagnosing the existence of dementia is just as inadequate as diagnosing the existence of a shoulder-hand syndrome. The reasons must be found and a number of advanced invasive and non-invasive methods are available today such as ultrasonography, computer tomography, measurements of the regional blood supply of the brain, angiography, electroencephalograms, laboratory tests, etc. Although all these advanced methods exist, a careful anamnesis and the clinical findings continue to be of significance for the aetiology of the disease. The author does not mention very rare diseases such as the group of leucodystrophies and subacute sclerosing panencephalitis, nor does he refer to diseases such as Whipple's disease, Creutzfeldt-Jakob disease, vitamin deficiencies and hormonal conditions, which may also accompany dementia.