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Biomedical subjects

I Smith

Publications and source records attributed to I Smith.

At least 415 records · Page 23Linked to original sources
PubMed1974

Natural history of phenylketonuria and influence of early treatment.

This study describes the intellectual development of twenty-eight sibling pairs with phenylketonuria in which the index case presented because of retarded development. In twelve pairs (group I) the "second" sibling was born subsequently, and in sixteen (group II) there was a second sibling already in the family at the time of diagnosis of the index case. The intellectual outcome of the second siblings of group II suggests that approximately 1 in 6 or 7 patients with untreated classical phenylketonuria achieves an I.Q. above 70, although with evidence of intellectual impairment. The highly significant difference in intellectual outcome between the early treated second siblings of group I and the late or untreated second siblings of group II demonstrates the beneficial effect of early treatment on the intelligence of affected children.

Child↗
PubMed1974

The effect of oral inorganic sulphate on the metabolism of 4-hydroxyphenethylamine (tyramine) in man: tyramine O-sulphate measurement in human urine.

1. Urinary excretion of tyramine O-sulphate in six normal human subjects after an oral dose of 125mg of tyramine hydrochloride alone, and with a supplement of Na(2)SO(4), was determined by using chromatographic and electrophoretic separations followed by spectrophotofluorimetry. 2. In every case the excretion of tyramine O-sulphate was increased significantly after sulphate supplementation.

Carbon Radioisotopes↗
PubMed1973

Facial fractures.

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Adolescent↗