[Possibilities of following-up and predicting the course of chronic renal insufficiency].
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Biomedical subjects
Publications and source records attributed to I Slugen.
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Spontaneous rupture of the parenchyma of the transplanted kidney occurs in 0.8 to 9.6 per cent of transplantations. Mortality is reported to be up to 9 per cent. Every rupture requires surgical intervention. In most cases graftectomy has to be performed. The cause of the rupture is an immunological destruction of the graft, the histological finding being a massive rejection of an interstitial type. In a set of 51 transplantations of cadaver kidneys rupture occurred in 4 patients (7.8 per cent). It was necessary to carry out a graftectomy in all cases immediately or later on.
A group of 157 children, 4-15 years old, suffering from various forms of glomerulonephritis were investigated. Associations between the HLA system and the clinical, morphological and therapeutic responses were looked for. The study revealed the following associations: chronic GN to B15 and B18; Schönlein-Henoch GN to B27, Bw35 and Bw40; focal GN to B18; mesangioproliferative GN to B27; susceptibility to corticosteroids to B18; resistance to corticosteroids to B15.
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