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Biomedical subjects

I Simonovits

Publications and source records attributed to I Simonovits.

18 recordsLinked to original sources
PubMed1986

Relationship between maternal and infant iron stores: 1. Full term infants.

Serum ferritin, serum iron and total iron binding capacity were determined in 218 pregnant women at term and in the cord blood of their normal term infants. Both the mean weight (3210 g) and serum ferritin level (geometric mean 81 micrograms/l) of the neonates of iron deficient mothers were significantly lower than those of mothers with "normal" iron stores (weight 3390 g; cord ferritin level 115 micrograms/l). A weakly significant correlation was found between the logarithm of the maternal and neonatal serum ferritin concentration (r = 0.15, p less than 0.05) and the maternal log serum ferritin and the newborn's weight (r = 0.15, p less than 0.05). The weak correlations were supported by the differences between the values of cord samples from babies of iron deficient mothers and those whose mothers had "normal" iron values. Adequate iron supplementation during the early period of pregnancy is suggested.

Adult↗
PubMed1985

The biological role of lactoferrin.

Lactoferrin (LF)--in various quantities--is present in human milk, secretions and polymorphonuclear neutrophils (PMN). LF's significance lies in its bacteriostatic effect on its environment. Probably it prevents bacterial uptake of iron, leads to damage of bacteria and during phagocytosis helps the organism to combat pathogens. Most likely it regulates iron absorption, and during inflammation it takes part in the plasma iron transport. LF is believed to play an important role in the regulation of granulopoiesis in the bone-marrow. From its biological effects it appears that plasma LF determinations may be useful in the clinical diagnosis of leukaemia and other malignant diseases, as well as in the study of iron metabolism.

Absorption↗
PubMed1980

Rate of Rh immunization after induced abortion.

The occurrence of Rh immunization was investigated in 386 secundigravidae whose first pregnancy was terminated by induced abortion and who were not given anti-D immunoglobulin after the induced abortion. Of these, 6 (1.57%) already proved to be seropositive at the beginning of their second pregnancy, another 6 (1.57%) became positive by the end of the second pregnancy, i.e. 3.14% altogether as demonstrated with papain-treated RBC. If instead the indirect antiglobulin (Coombs) test was used, 3 women (0.77%) proved to be positive at the beginning and 9 (2.31%) at the end of the second pregnancy. Supposing that 0.5% of the secundigravidae became immunized during the second pregnancy, the rate of immunization after induced abortion in non-protected cases may be calculated to be 2.64% using the papain technique and 1.81% when the antiglobulin test is applied.

Abortion, Induced↗
PubMed1980

[Not Available].

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History, Modern 1601-↗
PubMed1979

Efficacy of 100 microgram (250 IU) anti-D IgG in the prevention of Rh-haemolytic disease.

In the years 1975-1976, 6,766 unselected (ABO compatible and incompatible) primigravidae parturients with uncomplicated delivery were given 100 microgram (250 IU) anti-D IgG. A total of 4,473 presented for the 6-month control examination. IAGT was positive in 5 cases (0.11%). The 200 microgram (500 IU) dose was administered to 1,543 women. Of these, 962 presented for serological control. IAGT was positive in 1 case (0.10%). The difference is not significant. The findings support the results of previous studies suggesting that 100 microgram anti-D is a sufficient dose to prevent immunization in uncomplicated deliveries.

Dose-Response Relationship, Immunologic↗