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Biomedical subjects

I Simeone

Publications and source records attributed to I Simeone.

25 records · Page 2Linked to original sources
PubMed1985

[The demented patient: his family, social and therapeutic environment].

The patient's environment determines to a large extent the evolution of his illness. His family, which is almost always thrown into a state of confusion by the patient's illness, has the crucial role of providing support and protection even if they are overwhelmed by his needs. The support of the community is indispensable in order to assure the continuity of the parental role; therefore the need to create specialized services such as geriatric hospitals, hospices, special residences, out-patient therapeutic units, and social and medical services for care at home. The Geneva geriatric and gerontological experience is presented to better illustrate these needs.

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PubMedDate not supplied

Chemiluminescence activity in whole blood phagocytes of dogs naturally infected with Leishmania infantum.

Dogs are the domestic reservoir of Leishmania infantum, a vector-borne intracellular protozoan agent of human visceral leishmaniasis. The role of polymorphonuclear leukocytes (PMNs) in the immune defence against this parasite has been poorly studied. We have investigated the function of peripheral blood PMNs in naive beagle dogs that have been naturally exposed to phlebotomine vectors in an area highly endemic for canine leishmaniasis, and found infected by Leishmania at the end of the transmission season. Whole blood phagocyte oxidative metabolism was assessed by a rapid method that determines a luminol-amplified chemiluminescence (CL) emission. This was evaluated using either a soluble stimulant, phorbol mirystate acetate (PMA), or phagocytic stimuli, such as zymosan unopsonized (ZYM) or opsonized with autologous serum (OPZ). In blood samples taken 2 months after exposure to Leishmania transmission, data on CL emission revealed a significant decrease of reactive oxygen intermediates (ROI) production in the presence of both PMA and ZYM, compared with blood samples obtained from dogs before exposure. On the contrary, no variations in CL emission were detected in presence of OPZ. Our data indicate that immunological changes occur early in canine leishmaniasis and confirm that the role of PMNs and their products need to be clarified.

Animals↗