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Biomedical subjects

I Shah

Publications and source records attributed to I Shah.

34 records · Page 2Linked to original sources
PubMed1984

Acute basophilic leukemia.

Acute basophilic leukemia was diagnosed in a 61-year-old black woman on the basis of 85 to 90 percent basophils in the peripheral blood as well as bone marrow and very high serum histamine level (more than 10,000 ng/ml). These complications occurred as a transformation from essential thrombocythemia. Accompanying this transformation, there was also cytogenetic change from 46XX karyotype to 46XX 2p+ in 66 to 90 percent of cells in the bone marrow. This may be the first reported occurrence of transformation of essential thrombocythemia into acute basophilic leukemia.

Acute Disease↗
PubMed1984

Diagnostic morphometry of the adult respiratory distress syndrome (shock lung).

In the pathogenesis of "shock lung", the morphometric analysis allows us to determine the "point of no return" when the exudative alveolitis turns into the life-threatening sclerosing form. In addition, we found that this "point of no return" is reached much earlier in septic than in traumatic shock. Our studies confirm that the term "shock lung" should not be simply substituted for "respiratory lung". Based on our morphometric methods, we conclude that shock-induced pulmonary fibrosis differs with regard to its functional pathogenesis from the non-shock-induced type of fibrosis.

Epithelium↗
PubMed1984

Role of sialyltransferase in hypercupraemia of non-Hodgkin's lymphoma.

Copper, ceruloplasmin and sialyltransferase activity were measured in serum of 25 patients with lymphoreticular malignancies, in an attempt to study the sialyltransferase activity and correlation if any with the activity of the disease and ceruloplasmin. All 3 parameters were elevated in active disease but no definite correlation between sialyltransferase activity and copper or ceruloplasmin could be found. We conclude that plasma sialyltransferase activity is increased in lymphomas.

Adult↗
PubMed1983

True histiocytic lymphoma. A report of four cases.

Clinical, morphologic, cytochemical, immunologic, and ultrastructural features of four cases of true histiocytic lymphoma are described. The neoplastic cells were large, ranging from 20 to 45 mu in diameter with round, folded, or convoluted nuclei, and abundant eosinophilic cytoplasm. They exhibited diffuse nonspecific esterase activity. Diffuse acid phosphatase activity was present in two cases so tested. Muramidase activity was present in half of the cases. Finely granular PAS-positive material was seen in the cytoplasm. Methyl green-pyronin positivity was variable. An occasional neoplastic cell showed erythropagocytosis in one case. Malignant cells either contained no cytoplasmic immunoglobulins (three cases) or had immunoglobulins of multiple classes (one case). Surface markers were studied in two cases; they were absent in one case, and were of multiple classes in another case. Ultrastructurally the neoplastic cells had lysosomal granules in three cases so examined, and phagolysosomes, phagocytized material and residual bodies in one of three cases so studied. Patients ranged in age from 28 to 60 years. Two patients had extralymphatic tumors. Survival of more than 5 years was seen in one patient.

Adult↗
PubMed1983

Correlation of hypercupremia with other acute phase reactants in malignant lymphoma.

Levels of copper, haptoglobin, fibrinogen and Factor VIII were measured in 30 patients with non-Hodgkin's lymphoma on 90 occasions in an attempt to demonstrate a possible correlation between hypercupremia and other acute phase reactants. The four parameters were measured simultaneously in active disease and in remission. The serum copper, along with other parameters, was significantly elevated in the active disease (P less than 0.001) and there was a high correlation between the levels of serum copper, fibrinogen and haptoglobin (P less than 0.001).

Adult↗
PubMed1983

Renal oncocytoma associated with diffuse lymphoma.

We report on a sixty-six-year-old man with a poorly differentiated, diffuse lymphoma in whom bilateral multiple renal masses developed six months after starting chemotherapy. Computerized tomography and selective renal arteriograms were suggestive of either recurrence of lymphoma or renal cell carcinoma. Kidney biopsy revealed renal oncocytomas, benign renal tumors. The patient was spared further courses of cytotoxic therapy.

Adenoma↗
PubMed1983

Comparison of circulating colony-forming cells in chronic granulocytic leukemia and leukemoid reaction.

In vitro culture studies of peripheral blood leukocytes using semi-solid media from 8 patients with chronic granulocytic leukemia (CGL) and 5 patients with granulocytic leukemoid reaction were performed. A markedly increased number of circulating colony-forming units were present in patients with CGL (mean 343 +/- 47) as opposed to those having granulocytic leukemoid reaction (mean 7.0 +/- 4). The colony size was larger in CGL than in granulocytic leukemoid reaction or in normal peripheral blood.

Cells, Cultured↗
PubMed1982

Agranulocytosis associated with chronic oral administration of cloxacillin for suppression of staphylococcal osteomyelitis.

Oral cloxacillin was used for chronic suppression of a 59-year-old woman with staphylococcal osteomyelitis. She received 380.5 gm of cloxacillin over 263 consecutive days. Severe agranulocytosis followed, reverting rapidly to normal with cessation of drug. The absence of signs of an allergic reactions such as rash, fever, or eosinophilia suggests that cloxacillin, like other semisynthetic penicillins, may exert a direct bone marrow toxicity.

Agranulocytosis↗
PubMed1982

Granulocyte yields using the Haemonetics 30. Effects of variations in corticosteroid regimen and donor selection.

The factors of donor selection, corticosteroid drug choice, dose, timing and route of administration were studied to optimize granulocyte yield employing the Haemonetics Model 30 Blood Processor. Our data suggest that donors giving one excellent yield do not necessarily do so again. Donors with high initial granulocyte counts had only marginal increases in counts after taking corticosteroids. Selecting donors on the basis of high previous yield or granulocyte count is not a feasible strategy for improving granulocyte yields. Highest yields of granulocytes (16 X 10(9) total; 4 X 10(9)/liter processed) were obtained with any of four split-dose corticosteroid regimen. This increment is almost twice as large as the previously reported improvement using continuous-flow centrifugation. The choice of steroid, the route of administration and the timing of the split doses are not critical.

Administration, Oral↗
PubMed1982

Evaluation of individuals deferred from blood donation for medical reasons.

Modern techniques of blood collection require health screening of donors by non-physicians using general guidelines. Health problems of concern to the donor and possible loss to future donation of actually individuals are inherent in this acceptance and deferral process. Of the 108,908 donors presenting at the bloodmobiles of regional blood center from September 1978 to February 1979, 9,542 were deferred. Of these, 1,203 with possible medical problems other than hepatitis, hypertension, or infectious disease were referred to their physician for further information concerning their suitability as donors. Over 80% had irregular pulses or histories suggestive of potential cardiovascular problems. The purpose of this study was to review the evaluation mechanism. Responses for evaluation were received from only 222 out of 1,203 (18%), and of these all but 29 (13%) were granted full permission to donate. Since only one evaluated individual with pulse or cardiovascular findings of possible significance was under the age of 35 years, this age is a reasonable cutoff for such deferrals. The minimum increase in collections with this change in deferral screening would be over 1,000 units per year in Connecticut, and perhaps 60,000 nationwide.

Adult↗
PubMed1982

Karyotypic polymorphism in acute myelofibrosis.

Acute myelofibrosis (AMF) was diagnosed in a 59-yr-old black male in September 1978, on the basis of pancytopenia, lack of hepatosplenomegaly, fibrosis of the marrow, and paucity of teardrop red blood cells in the peripheral blood. Since then the patient has demonstrated an unusually long survival of 36 mo with a changing cytogenetic course. His initial 46, XY normal karyotype changed in 20 mo to trisomy 8, followed 1 yr later by 1:4 translocation in peripheral blood. Simultaneously with these changes, the fibrosis in the bone marrow progressively decreased, ultimately terminating in chronic granulocytic leukemia-like presentation with reversal to 46, XY karyotype. Fibroblast culture failed to show any evidence of cytogenetic abnormalities. The disappearance of fibrosis confirmed by trichrome and reticulin stains and lack of cytogenetic abnormalities in fibroblasts confirms the secondary role of fibrosis.

Acute Disease↗
PubMed1980

DNA in Lennert's lymphoma. Report of a case with cytophotometric studies.

We present the first case of Lennert's Lymphoma in which cytophotometric determinations for DNA contents are undertaken. DNA Histograms of lymphoid cells, Immunoblasts, and epitheloid cells are evaluated for their euploid or aneuploid DNA contents. The aneuploid DNA stem line pattern found in the case under discussion testifies to the malignant nature of Lennert's Lyphoma.

Aneuploidy↗