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I Serra

Publications and source records attributed to I Serra.

62 records · Page 4Linked to original sources
PubMedDate not supplied

Nucleolar and nucleoplasmic RNA polymerase activity in different regions of rat brain during postnatal development.

RNA polymerase activities of whole nuclei, of isolated and purified nucleoli and of the nucleoplasmic fractions obtained from cerebral hemispheres, cerebellum and brain stem of rat at different days of postnatal development have been determined. In the whole nuclei the fraction of RNA polymerase which is sensitive to alpha-amanitin, is strongly affected by salt concentration; at low ionic strength most of the activity is resistant to the drug while at high ionic strength the enzymatic activity shows a greater sensitivity to the drug. In isolated nucleoli RNA synthesis is not inhibited at all by alpha-amanitin. The biosynthesis of RNA, at low ionic strength, is inhibited by low doses of actinomycin D, whereas at high ionic strength it is remarkably inhibited only by higher doses of the drug. The sensitivity of the reaction to alpha-amanitin and actinomycin D provide good evidence that UTP or GTP incorporation into RNA in purified nuclei and nucleoli, is dependent on RNA polymerases acting on DNA template and is not dependent on homopolymer formation. These results show that in the whole brain nuclei at low ionic strength there is a preferential synthesis of rRNA, whereas at high ionic strength the synthesis of heterogenous RNA predominates. In isolated nucleoli the synthesis of RNA is restricted to rRNA.

Aging↗
PubMedDate not supplied

[Regional analysis of human and animal hydatidosis in Chile, 1989-1993].

A descriptive study of hydatidosis, a still very prevalent zoonosis in Chile, was carried out with information up to 1993. Both human and animal data were included, the last one based on more reliable information. Regional human distribution up to 1991 shows persistent high notification rates in the extreme south of the country, Aysen and Magallanes hospital discharges, more reliable than notified cases, adds the IX Region of Araucania to the high risk areas, join with more than 30 hospitalizations per 100,000 people in 1989. Mortality case rate suggests strongly a very high subnotification in all the regions, mainly in O'Higgins. This zoonosis affects predominantly, young and middle aged adults, with a similar sex distribution. Cattle infection has decreased in the last 20 years, particularly in sheep. Proportion of infected dogs also tends to show a lowering trend in specific studies. It appears a strong need of a national program for controlling this zoonosis, to be initiated with an epidemiological evaluation by regions and centered in health education, dogs' infection control with treatment and better handling of slaughterhouses.

Adolescent↗
PubMedDate not supplied

[Comparative study of 2 antibiotic prophylactic protocols in oncologic surgery of the pharynx and larynx].

The use of antibiotic prophylaxis in oncological pharyngeal and laryngeal surgery has reduced the risk of postoperative wound infection, which decreases morbidity and health-care costs. We report the results of a prospective randomized study in our hospital comparing the effectiveness of two antibiotic protocols, amoxicillin-clavulanate and clindamycin plus gentamicin, both given for 24 hours, in patients who underwent clean-contaminated oncological surgery of the pharynx or larynx.

Amoxicillin↗