Biomedical subjects
I Seifert
Publications and source records attributed to I Seifert.
Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity.
The hypothesis was tested that islet autoimmunity is induced by ongoing islet cell destruction in subjects with susceptibility genes HLA-DR 3 and/or DR 4. Sixty-one patients with confirmed chronic pancreatitis were analysed, 30 of whom expressed HLA-DR 3 and/or DR 4. Electron microscopy studies in 10 patients showed that the inflammatory process also affected islets, as recognisable from islet cell lysis, intrainsular fibrosis and immune cell infiltrates. None of the sera tested contained any of three markers of islet autoimmunity, ICA, IAA or GAD antibodies. A correlation was seen between the loss of exocrine function, as determined by the ALTAB-test, and of beta-cell function, as determined by the C-peptide response to i.v. glucagon. However, there was no preferential loss of beta-cell function in patients with HLA-DR 3 and/or DR 4. We conclude that islet cell destruction occurs during chronic pancreatitis, but does not trigger islet autoimmunity, even in the presence of HLA-DR 3 and/or DR 4.
[Manual therapeutic aspects of hip dysplasia - study with newborns].
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Age-related classification of pyramidal and stellate cells in the rat visual cortex: a Nissl study with the 'Morphoquant'.
(1) Using Nissl preparations and the automatic picture processing system 'MORPHOQUANT', VEB Carl Zeiss JENA, age-related classification of pyramidal and stellate cells of the layer IV in the rat's visual cortex was performed. (2) 12, 16, 20, 30, 90, and 420 days old animals were investigated. (3) Due to the high cell density and immature stage the neurons of an 8-day-old animal could not be measured. (4) A review is given about the automatic picture processing system 'MORPHOQUANT' and the applied computer program. (5) The analysis of one cell soma with the 'MORPHOQUANT' amounts to about 30 seconds. (6) The computer accepted 30 to 50% of the offered objects. The remaining ones could not be discriminated from the neighbourhood. (7) 14 standard features are registered and 7 statistically evaluated preferential taking into consideration area, form and texture of the objects. (8) 4 features are statistically relevant: soma area in picture points (KOFL) and whole extinction (EXTS) correspond to soma size; compactness (KOMP) and concentration of high grey values in the central part of the object (ZNTR) correspond to structural features of the soma, i.e. the structural density and the distribution patterns of strong coloured RNA and DNA particles. Form factors are not statistically relevant. (9) With increasing age the morphological features are clearer and the performance of the classificator is higher. (10) Soma size and structure of pyramidal and stellate cells develop similarly to an overshooting growth curve. The values reach the maximum approximately on postnatal day 16. (11) Age-related methodological and neurobiological problems are discussed.
[Functional aspects of C-scoliosis in infants].
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