Biomedical subjects
Publications and source records attributed to I Schindera.
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Neurodermatitis or atopic dermatitis appears to be more widespread among animals than has been assumed hitherto. We report on a female gorilla in Saarbrücken Zoo; after years of captivity the animal developed recurrent eczema in the crooks of the elbows and knees. An interesting aspect of this case is that apparently psychological factors stemming from a partner conflict led to manifestation of the disease. We discuss the feasibility of determining the presence of IgE.
Absent enzyme activity of hypoxanthine-guanine-phosphoribosyl transferase in erythrocytes was demonstrated in the blood from a 21-year-old man with spastic tetraplegia, choreoathetosis, oligophrenia, and hyperruricaemia which developed after birth. But there was no tendency towards self-mutilation, considered to be characteristic of the full-blown picture of the disease. This case thus runs counter to the view that the enzyme defect is the cause of the inevitable, stereotyped change in behaviour. Unusual morphological changes of all blood-cell systems confirm the dependence of nucleic acid synthesis on the "salvage pathway" of the purine nucleotides, which is abnormal in this inherited disease.
This paper reports a family with typical features of hidrotic ectodermal dysplasia (h.e.d.). Although some members of the family showed phenotypical similarities to anhidrotic ectodermal dysplasia, there is no doubt about the classification of this disorder into hidrotic ectodermal dysplasia because of its manifest symptomatology (hypo- and dystrichosis deformity of nails, autosomal-dominant heredity, normal sweating). This suggests that the phenotypical similarities are obvious and important findings of h.e.d.