Biomedical subjects
Publications and source records attributed to I Sano.
A woman with aortitis syndrome who had had severe hypertension for more than 30 years, despite the administration of various antihypertensive drugs, underwent percutaneous transluminal angioplasty (PTA) a total of three times. The operation resulted in good control of BP and with an improvement of other hemodynamics without any medication for one year after PTA.
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The metabolism of putrescine in rat brain was studied systematically by the intraventricular injection of radioactive diamine. Putrescine injected into the brain was metabolized mainly to polyamines, spermidine, and spermine. A small portion of the radioactivity of putrescine was incorporated into gamma-glutamylputrescine, putreanine, gamma-aminobutyric acid, and homocarnosine. Comparison of the specific radioactivities of gamma-aminobutyric acid and homocarnosine after the injection of radioactive putrescine with those after the injection of radioactive glutamic acid indicated that there may be a metabolic pool of gamma-aminobutyric acid (putrescine-gamma-aminobutyric acid system) which is different from the glutamic acid-gamma-aminobutyric acid system and which is effectively used for synthesis of the dipeptide.
1. N-Monoacetylspermidine A and B were isolated from human urine. Structures of the isolated compounds were assigned to monoacetylspermidines by analyses of the products of acid hydrolysis and elementary analyses. The identification was confirmed by comparison of the chromatographic and electrophoretic properties and infrared spectra of the isolated compounds with those of the authentic compounds. 2. The concentrations of urinary polyamines were determined by the combination of ion-exchange chromatography and high-voltage paper electrophoresis. The amount of putrescine fell in the range of 1--6;spermidine, 1--3;spermine, 3--15 and N-acetylspermidines, 2--10 nmoles/mg creatinine for both sexes and different ages. 3. The amounts of urinary polyamines were measured in patients with cancers. The remarkable increase of urinary spermine was observed in blood cancer, while in the other solid cancers the increase of urinary polyamines was not observed.
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