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Biomedical subjects

I Sando

Publications and source records attributed to I Sando.

161 records · Page 9Linked to original sources
PubMedDate not supplied

Temporal bone histopathologic findings in oculoauriculovertebral dysplasia. Goldenhar's syndrome.

The right temporal bone of a 6-month-old patient with oculoauriculovertebral dysplasia (Goldenhar's syndrome) was examined histopathologically. The most striking abnormalities were deformity of the auricle, atresia of the external auditory canal, severe malformation of middle ear structures, and incomplete development of the oval window. No inner ear abnormalities were identified in this case.

Goldenhar Syndrome↗
PubMedDate not supplied

Postnatal development of the eustachian tube and its surrounding structures. Preliminary study.

The postnatal development of the eustachian tube and its surrounding structures (tubal cartilage, tubal gland, tensor veli palatini muscle, and levator veli palatini muscle) was investigated in serial vertical histologic sections from 12 normal temporal bones of individuals whose ages ranged from 39 weeks' gestation to 19 years of age. After projecting tissue sections onto paper and tracing the structures, several measurements were made in order to analyze this development. Findings revealed that the eustachian tube and its accessory structures developed postnatally up to the age of 19 years. The lumen area in a 19-year-old specimen was 4.7 times that of the 1-day-old infant. The development of the tube was greatest in the pharyngeal part. Postnatal development of the eustachian tube appears to be related to growth of the face. The cartilage area in the 19-year-old specimen was 3.6 times that of the 1-day-old infant. The mucosal acinar cells were predominant in infants but no greater than the number of serous acinar cells by the age of 19 years. The areas of the tensor and levator veli palatini muscles in a 19-year-old specimen were 5.1 and 11.1 times, respectively, those of the 1-day-old infant. This preliminary study reports the postnatal development of the eustachian tube and its accessory structures, a subject never thoroughly investigated to date. However, because of the limited number of cases available, further investigation of a greater number of cases should be performed so that the relationship between tubal development and alterations in function that occur with age can be understood clearly.

Adult↗
PubMedDate not supplied

Mesenchyme remaining in temporal bones from patients with congenital anomalies. A quantitative histopathologic study.

Our hypothesis that more mesenchyme remains for a longer time in the middle ear clefts of infants with congenital anomalies in the ear and/or other parts of the body than in the ears of infants without such anomalies has been tested. One hundred four human temporal bones obtained from 81 individuals with congenital anomalies in the ear and/or other parts of the body, with ages ranging from 24 weeks' gestation to 35 years, were processed histologically, stained with H & E, and examined under the light microscope. The slides were projected under a microprojector, and the mesenchyme remaining in each of 19 portions of the middle ear cleft was measured by compensating polar planimetry and expressed as a percentage of the total potential middle ear space in that histologic section. By comparing the findings in the present study with those of a previous study in which mesenchyme remaining in ears from normal age-matched controls was measured, we found that more mesenchyme remained for a longer time in the middle ear cavities of infants with congenital anomalies than in those of control infants (p less than .01). In addition, the amount of mesenchyme remaining was in direct proportion to the degree to which development of the middle ear was anomalous.

Adolescent↗
PubMedDate not supplied

Localization, frequency, and severity of endolymphatic hydrops and the pathology of the labyrinthine membrane in Menière's disease.

The localization, frequency, and severity of endolymphatic hydrops in 22 temporal bones of 16 individuals with Meniere's disease were studied histopathologically. Endolymphatic hydrops was more often observed in the pars inferior (22/22) than in the pars superior (13/22) of the temporal bone, and severe hydrops was observed most frequently in the saccule, followed by the cochlea, the utricle, and the three semicircular canals. In the cochlea, the most severe hydrops was observed in the apical turn, followed by the hook portion, the middle turn, and the basal turn. Clinically interesting observations regarding endolymphatic hydrops included bulging into the perilymphatic space of the vestibule. In 17 of 22 bones the saccular membrane bulged into the vestibule laterally and was attached to the footplate of the stapes. In two of 22 bones, Reissner's membrane in the hook portion of the basal turn of the cochlea bulged superiorly into the vestibule, occupying most of the perilymphatic space of the vestibule.

Cochlea↗
PubMedDate not supplied

Computerized data bank system for temporal bone histopathology.

A computerized data bank system to store and analyze temporal bone histopathologic data is described. This system uses the University of Pittsburgh's Digital Equipment Corporation System 10 computer and the System 1022 data base management software. Data on histology cases are divided into five files: general information, otologic information, summary, histopathologic information about the external ear and middle ear, and histopathologic information about the inner ear. Eleven general terms are used to describe pathologic findings, surgery, postmortem degeneration, and artifacts. In addition, provision is made for the inclusion of more precise qualitative information to be entered as text.

Computer Systems↗
PubMedDate not supplied

Histopathologic study of eustachian tube in cleft palate patients.

We studied eight temporal bones from eight individuals with cleft palates (CPs) and eight age-matched control temporal bone specimens from our collection. We used the eustachian tube (ET) and its surrounding structures in serial vertical histologic sections. The findings observed in CP specimens were as follows: 1) the angle between axial lines through the tensor veli palatini (TVP) muscle and the superior portion of the ET lumen was narrow, 2) the angle between axial lines through the lateral lamina and the medial lamina of the cartilage was wide, 3) the angle between axial lines through the TVP muscle and the lateral lamina of the cartilage was narrow, and 4) the angle between axial lines through the superior part and the inferior part of the ET lumen was wide. From these findings, we assume that the ET dysfunction that occurs in individuals with CP is the result of abnormalities of the ET and its cartilage and of abnormal anatomic relationships of these structures to the TVP muscle.

Cleft Palate↗
PubMedDate not supplied

Hypoplasia of the vestibular aqueduct and endolymphatic sac in endolymphatic hydrops.

Four temporal bones from three previously reported cases showing endolymphatic hydrops and pathology of the vestibular aqueduct (VA) and endolymphatic sac (ES) were investigated further. Pathology of the VA and ES was studied by measuring the sizes of the VA and ES, paying particular attention to the proximal rugose portions. A medial-view graphic reconstruction was created to delineate the course and size of the VA, as well as its correlation with neighboring structures (posterior canal and cochlea). In addition, 20 control temporal bones were selected and measured for quantitative study of the sizes of the VA and ES. The four pathologic temporal bones were shown to have small, simple, tube-like VA and ES, without surrounding bony pathology. This appeared to be congenital hypoplasia characterized by hypoplastic funnel-shaped dilatation of the VA and hypoplastic rugose portion of the ES. Anterior dislocation of the distal portion of the VA and poorly developed periaqueductal air cells were also noted in the pathologic bones.

Adolescent↗
PubMedDate not supplied

Temporal bone histopathologic findings in congenital anomalies of the oval window.

The histopathologic findings in five temporal bones from three cases showing various stages of oval window development arrest are presented. The anomalies ranged from complete absence of the oval window to congenital cartilaginous fixation of the stapedial footplate. Surgical approaches fro establishment of a new oval window must take into consideration the frequent association of facial nerve anomalies with anomalies of the oval window.

Ear, Inner↗
PubMedDate not supplied

Perilymphatic communication routes in the auditory and vestibular system.

Horseradish peroxidase was injected into the foramen magnum and oval window of guinea pigs to determine perilymphatic communication routes and boundaries. The primary route to the auditory system appeared to be through the cochlear aqueduct. Perineural spaces of the eighth nerve contributed to this communication and provided the principal perilymphatic communication routes to the vestibular system. Light and electron microscopic examination were used to identify membrane permeability and define boundaries in the epithelial lining of the auditory and vestibular endorgans.

Animals↗
PubMedDate not supplied

The vestibular aqueduct in patients with Meniere's disease. A temporal bone histopathological investigation.

Meniere's disease (idiopathic endolymphatic hydrops) was studied in human temporal bone histology sections. Measurements were made of the area, length, width, angle, position, and external aperture of the vestibular aqueduct in 27 temporal bones of individuals with this disease. These measurements were compared with measurements of the same parameters in 88 normal temporal bones. It was found that small vestibular aqueducts were more often observed in the temporal bones of patients with Meniere's disease than in temporal bones from individuals without this disorder. The difference in size of the vestibular aqueduct in bones with hydrops and normal bones was statistically significant.

Adult↗
PubMedDate not supplied

Anatomy of the round window. A histopathological study with a graphic reconstruction method.

The round window was studied in normal adult and infant temporal bones to provide a knowledge base for the study of congenital anomalies of the round window, and to determine whether the round window develops postnatally. Fifty-three temporal bones were studied. Specimens were processed histologically, sectioned horizontally, stained with hematoxylin and eosin, and studied under the light microscope and microprojector. A special method of graphically reconstructing the round window was developed for this study, and was used to define the contour, area, and angle of the round window. We found that the round window is fan shaped. The area of the superoposteriorly located horizontal part (three-sevenths of the round window) and of the inferoanteriorly located vertical part (four-sevenths of the round window) totals approximately 2.29 mm2. In addition the angle between the plane of the tympanic sulcus and the vertical part of the round window was measured, and found to average 73.3 degrees. Lastly, the round window was found not to develop postnatally.

Adult↗
PubMedDate not supplied

Computer-aided three-dimensional reconstruction and measurement of semicircular canals and their cristae in man.

We studied the spatial relations of the semicircular canals (SCCs) and their cristae, by computer-aided three-dimensional reconstruction, a graphic method we developed. The angles between pairs of SCCs, between pairs of SCC cristae, and between a SCC and its crista were measured using histology sections of a normal temporal bone from a 14-year-old female. Angles between pairs of SCCs and pairs of cristae deviated 11.3 to 18.2 degrees and 4.8 to 18.0 degrees, respectively, from right angles and the long axis of each crista deviated 25.0 to 30.4 degrees from the line perpendicular to the plane of the corresponding SCC; thus none of these structures lies at a right angle to another. We believe these new anatomical findings will help in the clinical evaluation of SCC function.

Adolescent↗
PubMedDate not supplied

Temporal bone histopathological findings in trisomy 13 syndrome.

This study reports the histopathological findings of 14 temporal bones from infants with trisomy 13 syndrome. The most primitive anomalies in the structures of the inner and middle ears in the present series are those of the semicircular canals, particularly of the horizontal canals: flattened horizontal canal cristae, absence or opening of the utricular endolymphatic valve, small facial nerve, and obtuse angle of the geniculate area of the facial nerve. Each ear demonstrated more than one of those anomalies. The anomalies present features similar to those found in the structures of the normal six to ten-week fetus. Many other mild anomalies observed appear to demonstrate features similar to those seen in the same structures in later fetal life. Reviewing these findings, most of the anomalies that were found in the inner and middle ears appear to be the result of poor development of the structures for reasons which are now unclear. In addition, middle ear infection was found in all cases.

Abnormalities, Multiple↗
PubMedDate not supplied

Congenital anomalies of the inner ear: introducing a new classification of labyrinthine anomalies.

In a literature review of 108 articles a special effort was made to find and classify inner ear anomalies and diseases associated with inner ear anomalies. This study showed the following. Most of the diseases associated with inner ear anomalies are also associated with anomalies in other parts of the body. Hereditary characteristics comprise the most common etiological factor among the diseases associated with inner ear anomalies. Among anomalies observed in the cochlea, the vestibule, and the semicircular canals, anomalies in the cochlea are most frequently associated with various diseases and were observed in 30 of 40 diseases. Anomalies of the vestibule were observed in 25 diseases, and those of the semicircular canals in 18 diseases. Anomalies in both the osseous and the membranous labyrinth were most frequently associated with the diseases studied, as they were observed to occur with 10 of the 43 diseases. In this paper a new classification system for labyrinthine anomalies is introduced, based on this study of the literature.

Ear, Inner↗
PubMedDate not supplied

Dimensional anatomy of the vestibular aqueduct and the endolymphatic sac (rugose portion) in human temporal bones. Statistical analysis of 79 bones.

The purpose of this study was to investigate the anatomy of the vestibular aqueduct (VA) and rugose portion (RP) of the endolymphatic sac. Serial horizontal sections of 79 normal temporal bones of individuals aged 20 to 102 years were used. Medial view graphic reconstruction of the VA was performed for each specimen to determine the area, length, angle and position of the VA. The relationship between the width of the VA and the area of the VA, and the relationship between the degree of development of the VA and the degree of development of the temporal bone (periaqueductal pneumatization and the otic capsule in the periaqueductal region) were also investigated. Measurements of the RP were also made and further histological study of the RP was performed on 30 selected specimens. We found that 1) the VA in adult temporal bone varies in size and can be classified as hypoplastic, normoplastic, or hyperplastic; 2) many of the VAs in each group have similar sizes, although they vary in length, angle, or position; 3) all or most of the RP was located within the VA in all but one specimen, which had a hypoplastic VA (in this specimen more than half of the entire RP extended into the posterior cranial fossa); 4) the histology of the RP was characteristic in each type of VA; and 5) the degree of development of the VA seems to correlate with the degree of development of the otic capsule in the periaqueductal region.

Adult↗
PubMedDate not supplied

Postnatal development of the vestibular aqueduct and endolymphatic sac.

The purpose of this study was to gain basic information about the postnatal development of the vestibular aqueduct (VA) and the endolymphatic sac (ES). For this study, serial horizontal sections of 31 normal temporal bones of individuals whose ages ranged from 0 to 13 years were used. Medial view graphic reconstruction of the VA and rugose portion (RP) of the ES was performed in every case for analysis of the VA and RP. The findings of this study revealed the following new information about the postnatal development of the VA and ES. 1) The VA and RP undergo significant growth postnatally up to age 3 years. 2) In the newborn, individual variations in the VA and RP already exist and at age 3 years significantly wide individual variations which can be classified into three groups (hypoplastic, normoplastic, hyperplastic) may be recognized. 3) Hypoplastic VAs are of two types: one is fairly elongated and tubelike while the other is short and funnel-shaped. The tubelike VA seems to be the prenatal form. 4) The changes that occur with development postnatally in the area of the VA are more closely related to the changes that occur in the length of the external aperture of the VA than they are to the changes that occur in the length of the VA. 5) Development of the area of the VA is closely correlated with development of the area of the RP.

Adolescent↗