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Biomedical subjects

I Sakamoto

Publications and source records attributed to I Sakamoto.

At least 91 records · Page 5Linked to original sources
PubMed1982

The antitumor action of bacterial extracts. II. Suppressive effects of extracts of E. coil on subcutaneous tumors of mouse.

Subsequent to the previous report showing that the French pressure cell extract of E. coli exhibited a marked antitumor effect against several ascites tumors in the mouse, it has been demonstrated presently that the extract and the proteinous fraction obtained from cells of E. coli exert a definite suppressive effect against subcutaneous solid form tumors of mouse including young generation transplants of spontaneous mammary carcinoma arisen in C3H/He mice. However, occasional enhanced growth brought about by similar treatments left an important problem unsolved.

Animals↗
PubMedDate not supplied

Efficacy of an antibiotic coated indwelling catheter: a preliminary report.

This study was conducted to examine if an aminoglycoside (dibekacin sulfate, DKB) incorporated into a coating layer on outer and inner surface of indwelling catheters would be released into urine both in vitro and in clinical cases on a sustained basis and if the released DKB would have any efficacy on delaying lower urinary tract infections. Released amounts of DKB from the catheter silicone rubber (SR) catheter were periodically measured both in vitro and in clinical applications. During the clinical applications, the catheters were indwelled in 14 patients. Organism counts in the patients' urine were determined and organisms were isolated from bacteriuria (defined as greater than or equal to 10(4) CFU/mL) and MICs to DKB were measured. Observations on several combined symptoms frequently associated with indwelling catheterization were performed. Results showed that sustained release of DKB continued for more than 25 days and 13 days in vitro and in clinical cases, respectively. Clinical studies suggested that 8 days of sterile urine after catheterization might be expected in patients without systemic administration of antibiotics and more than 2 weeks if combined with it. No particular problems in its use and associated symptoms were recognized.

Catheters, Indwelling↗
PubMedDate not supplied

Takayasu arteritis: MR manifestations and diagnosis of acute and chronic phase.

Diagnosis of Takayasu arteritis is difficult because the clinical features are similar to those of other diseases. In the late occlusive or pulseless phase Takayasu arteritis, angiography usually demonstrates luminal changes such as such as stenosis, occlusion, or aneurysmal dilatation of the aorta and pulmonary artery and of their branches. However, absence of such luminal changes does not exclude the possibility of early or systemic phase Takayasu arteritis. Cross-sectional scanning such as CT scan and MRI plays an important role in demonstrating arterial wall changes in the early diagnosis of Takayasu arteritis. Improvement in the clinical findings and subsidence of the active inflammatory process can be expected with early steroid treatment. The common and uncommon MR appearances of the late occlusive phase and the recently described radiographic features of the early systemic phase are illustrated.

Diagnosis, Differential↗
PubMedDate not supplied

Acute renal infarction caused by Behçet's disease.

A case of acute renal infarction due to Behçet's disease is described. Selective renal arteriography revealed multiple microaneurysms of both kidneys and arterial obstruction distal to an aneurysm in the left kidney. Bilateral microaneurysms were no longer seen on the follow-up angiogram 5 years later. Behçet's disease should be considered in the differential diagnosis of acute renal infarction in young adults.

Acute Disease↗
PubMedDate not supplied

Therapeutic ethanol injection of hepatocellular carcinomas undetectable by angiography and Lipiodol computed tomography.

Seven smaller than 2 cm in diameter hepatocellular carcinomas (HCC) undetectable by hepatic arteriography and computed tomography (CT) after intraarterial injection of iodized oil (Lipiodol CT) were diagnosed by ultrasonography-guided fine-needle biopsy in 6 patients. All lesions were treated by percutaneous ethanol injection (PEI) in 1-3 weekly intervals. No recurrences have been demonstrated after 7-15 months. The treatment of HCCs undetectable by angiography and Lipiodol CT presents a problem as transcatheter arterial embolization is considered ineffective due to poor vascularity. PEI appears to be an excellent treatment for these small HCCs.

Aged↗
PubMedDate not supplied

Spontaneous rectus sheath hematomas: clinical and radiological features.

We reviewed the clinical and radiological features in eight patients with spontaneous rectus sheath hematoma (RSH). The diagnosis was confirmed at surgery in four patients, and spontaneous resolution occurred in the other four. All patients were elderly adults. Acute abdominal pain and a palpable mass after muscular strain, such as coughing or twisting, were features highly suggestive of RSH. Sonographically, these hematomas may be confused with abdominal wall tumors. On CT scans, a hyperdense mass posterior to the rectus abdominis muscle with ipsilateral anterolateral muscular enlargement is considered characteristic of acute RSH, although chronic RSH may be isodense or hypodense relative to the surrounding muscle. MRI is very useful in the diagnosis of RSH, which is demonstrated as a high signal intensity area on both T1- and T2-weighted images, especially when the CT findings are not specific for RSH.

Abdomen, Acute↗