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Biomedical subjects

I S Grover

Publications and source records attributed to I S Grover.

25 records · Page 2Linked to original sources
PubMed1987

Genotoxic effects of some organophosphorus pesticides. II. In vivo chromosomal aberration bioassay in bone marrow cells in rat.

The genotoxic effects of 4 organophosphorus pesticides, i.e., ekatin, fenitrothion, methylparathion and phorate, were assessed employing in vivo chromosomal aberration bioassay in bone marrow cells in rat. Methylparathion and phorate were found to be mutagenic while ekatin was weakly mutagenic. The frequency of chromosomal aberrations induced by fenitrothion did not differ significantly from that observed in negative control.

Animals↗
PubMed1985

Genotoxic effects of some organophosphorous pesticides. I. Induction of micronuclei in bone marrow cells in rat.

The genotoxic effects of 4 organophosphorous pesticides, i.e. ekatin, fenitrothion, methylparathion and phorate, were examined employing the micronucleus test in bone marrow cells of the rat. Methylparathion and phorate were found to be mutagenic, while ekatin was weakly mutagenic. The frequency of micronuclei induction by fenitrothion did not differ significantly from that noticed in negative control.

Animals↗
PubMed1982

Effects of methionine sulphoximine on protein transients during heterocyst differentiation in Anabaena and Cylindrospermum spp.

Heterocystous blue-green algae normally do not develop heterocysts if grown in the medium enriched with ammonium compounds. If such cultures are resuspended in a medium lacking combined nitrogen, the heterocysts differentiate within 24 h. L-methionine-DL-sulphoximine (MSO) has been reported to induce heterocysts even in the presence of ammonium chloride. The changes in gel electrophoresis protein profiles of cultures developing heterocysts, in the ammonium chloride enriched medium supplemented with MSO suggest that heterocyst differentiation in the presence of ammonium chloride and MSO may be due to derepression of heterocyst formation genes by MSO.

Cell Differentiation↗
PubMed1981

Effect of rifampicin on the heterocyst pattern in Anabaena ARM 314.

Alteration in the pattern of heterocysts is observed when suspending ammonia-grown filaments of Anabaena ARM 314 in a medium devoid of combined nitrogen source but supplemented with rifampicin. Paired as well as strings of 3--9 heterocysts were noticed. The electrophoretic protein pattern of non-heterocystous, heterocystous and multiple heterocystous filaments revealed that multiple heterocystous filaments are characterized by the presence of two additional protein transients. It is speculated that rifampicin may lead to an alteration in the enzyme system involved in the synthesis of inhibitory substances or, alternatively, to the formation or activation of enzyme systems involved in the sequestering of inhibitory substances.

Chloramphenicol↗
PubMed1980

Protein-transients during heterocyst differentiation in Anabaena circularis and Cylindrospermum sp.

The programme of protein synthesis accompanying cellular differentiation to the heterocyst following transfer of the blue-green algae Anabaena circularis and Cylindrospermum sp. (CBSC 1755) from ammonia-enriched medium to nitorgen-free medium was determined by polyacrylamide gel electrophoresis of whole proteins during successive intervals of differentiation. Besides this, total proteins and soluble amino acids were determined quantitatively. At least 4 sets of proteins can be distinguished on the basis of the time at which they are synthesized. Besides this, differentiation is distinguishable on the basis of the time at which their synthesis is turned off. The postmaturation stages revealed the synthesis of two sets in A. circularis andone in Cylindrospermum so. (CBSC 1755).

Amino Acids↗