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Biomedical subjects

I S Derizhanova

Publications and source records attributed to I S Derizhanova.

At least 19 recordsLinked to original sources
PubMed1998

[C-cells in malignant epithelial tumors of the thyroid gland].

An original procedure using points to evaluate the degree of tumor cell differentiation was employed in examining patients with papillary (42), follicular (33), medullary (19) and anaplastic (2) thyroid cancer. C-cell hyperplasia was detected in 26 out of the total of 94 cases (27.6%). It was the backdrop for each form of thyroid cancer and increased as tumor cell differentiation decreased. Three grades of C-cell hyperplasia were identified: I--11-20; II--21-49 and III--over 50 cells. According to anaplastic degree, it was typical and atypical; according to spreading pattern--focal, diffuse and nodular. Typical or diffuse hyperplasia was detected in well-differentiated cell tumor, while the atypical pattern prevailed in poorly- and moderately-differentiated ones. Most attention should be given to cases of subcapsular atypical hyperplasia of small C-cells showing initial well-differentiated cells of medullar thyroid cancer (C-cell microcarcinoma).

Adenoma↗
PubMed1993

[Cause of death in patients after surgical treatment of hemorrhagic incidence].

38 of 50 patients with hemorrhagic apoplexy were operated on. The most frequent causes of the death were progression of the hemorrhagic syndrome, intraventricular hematomas, thromboembolism of the pulmonary artery and its branches. Frequent complications were diencephalo-catabolic syndrome, polybacterial pneumonia, acute renal failure.

Adolescent↗
PubMed1990

[The morphological characteristics of endocrine-cell cancers of the large intestine].

Histological variants of colon carcinoma depending upon the quantity of endocrine cells are distinguished on the basis of 66 malignant epithelial colon tumours morphological investigation. Special emphasis was made on the characteristics of the endocrine cell carcinoma, combined tumours with a combination of glandular and endocrine components, and amphicrin neoplasms. A trabecular-glandular variant of endocrine cell carcinoma is found to be predominant in the colon. The criteria are suggested for the identification of endocrine-cell tumours.

APUD Cells↗
PubMed1989

[Stomach and duodenal ulcer in endocrine tumors].

Clinico-anatomical analysis was performed in 13 cases of endocrine tumors of various sites with concomitant gastric and duodenal ulcer (Zollinger-Ellison's syndrome). Ulcer tended to recur in these patients; it was associated with pronounced pain and involved a high rate of such complications as perforation, bleeding and gastrointestinal fistula. Endocrine tumors were found to locate in the pancreas (5) and duodenum (5) while, in the other three patients, multiple endocrine adenomatosis (type 1) was identified. Correct diagnosis was made in three cases only and surgery was successful in two of them. Errors are analysed.

Adult↗
PubMed1989

[The question of the functional significance and origin of pulmonary "tumorlets"].

In 1955, the term "tumorlets" was proposed to denote unusual microscopic clusters of epithelial cells occasionally detectable in the lung. The endocrinal nature of these formations has been proved, but there are conflicting opinions on the essence of the process (hyperplasia, dysplasia, and neoplasia). Pulmonary proliferation of endocrinal cells, which was similar to that of tumorlets, was found in 2 of 4 observations. The analysis of the results of the studies performed by the authors and of data available in the literature makes it possible to conclude that the proliferates of pulmonary endocrinal cells are, in terms of their functional significance, heterogeneous. Some of them appear as preneoplastic hyperplasia of endocrinal cells. The individual clusters acquiring independent blood circulation (stroma) may be regarded as true tumor-microcarcinoids. The authors also define the transitional forms between hyperplasia and neoplasia.

Adult↗
PubMed1989

[Clinico-anatomical comparisons in duodenal carcinoid tumors].

A clinical and anatomic analysis was made of duodenal carcinoid tumors in 5 male patients (mean age 43.2 years). The tumors were present in the areas of the major duodenal papilla (in 3 cases), those of the bulb (1) and horizontal part of the duodenum (1). They were multiple in 2 cases. Clinically, signs of gastrin activity, i. e. recurring ulcers in various segments of the gastrointestinal tract (Zollinger-Ellison syndrome), were most common. Other changes included impairments in the biliary tract and liver. The causes of death were hepatic and renal insufficiencies (2 cases), thrombohemorrhagic events (2). In the closed glands, nesidioblastosis and thyroid C cell hyperplasia were detected, one case having type I multiple endocrinal neoplasia (adrenal corticosteroma, pancreatic apudoma). In three cases, the metastases invaded into the liver and lymph nodes. Direct correlation was not established between the tumor sizes, metastases and hormonal activity signs. All the tumors had not been recognized in the patients' life. The paper discusses if it is possible to make life-time diagnosis.

Adult↗
PubMed1988

[Morphological characteristics of carcinoid angio- and cardiopathies].

Cardiovascular affections due to carcinoids can be divided into two groups: related to impaired vascular tonicity, and resultant from proliferative structural response of the heart and vascular walls. The former changes can be evident from arteriolar spasms and microcirculatory ectasia in the tumor, adjacent and distal tissues (myocardium, kidneys, skin). Proliferation, typical for EC-cell tumors, involved active multiplication of smooth muscle cells as well as of subendothelial and perithelial myofibroblasts with formation of specific mixed connective tissue responsible for vascular stenosis and giving rise to valvular disease.

Carcinoid Tumor↗
PubMed1986

[Electron microscopic characteristics of carcinoid tumors of varying localization and degree of differentiation].

Results of an electron-microscopic study of 15 carcinoid tumours of different sites were compared to those of histological and histochemical investigation. Highly differentiated tumours (6 observation had pronounced tissue and organ-specific features, contained a high number of argentaffin and/or argyrophilic endocrine granules in all cells. Moderately differentiated tumours (3 observations) showed a typical structure and abundance of secretory granules in the cytoplasm; when the chromatin of their nuclei became coarse, consisting of large clumps, karyolemma invaginations and bulging appeared, this being a sign of malignization. These nuclei changes progressed in the poorly differentiated tumours, number of secretory granules decreased (they were absent in 50% of cells). Argentaffin carcinoid of the appendix, intestine and cecum contained mainly serotonin granules (diameter 200-350 nm) and small number of polypeptide hormones granules (diameter less than 200 nm). The inverse correlation between the granules was observed in the bronchial carcinoid.

Appendiceal Neoplasms↗
PubMed1985

[Lung apudomas].

As a result of a complex morphological examination of 140 cases of lung neoplasms, 24 apudomas (17.11%) and 3 carcinomas (2.14%) were identified. The latter consisted of histologically-heterogeneous lesions containing endocrine cells in combination with epidermoid or glandular cells. Clinical symptoms as well as cytologic, histological, histochemical and electron microscopic characteristics of the tumors were studied. Most of those tumors were poorly-differentiated, histologically identical to various types of small-cell lung carcinoma, or--less frequently--solid lesions and other types of tumor. The above tumors can be detected by special diagnostic procedures.

Adult↗
PubMed1984

[Cytological characteristics of carcinoid tumors of the respiratory and digestive organs].

The paper discusses the results of a study of 22 primary and metastatic carcinoids which occurred in respiratory and digestive tracts with varying degree of differentiation. They formed the basis of the following cytologic criteria for their diagnosis: monomorphism of small cell elements, among which dark and clear ones can be distinguished; small-lumped chromatin pattern in nuclei of clear cells; and teniform and perivascular structures. Diagnosis was verified in all cases by histological and histochemical methods which were complemented by electron microscopy in 3 cases. On the basis of the said characteristics, tumors with endocrine differentiation can be distinguished from other pulmonary and digestive tract neoplasms.

Biopsy↗
PubMed1983

[Morphogenetic potentials of the enterochromaffin cells in tumor growth].

The structure of 69 argentaffine-cell serotonin-producing carcinoids was studied. The concentration of cells which display the morphofunctional characteristics of enterochromaffin cells was found to vary within a wide range: from constituting the bulk of cell element population to few or even solitary cells. The variegated histological patterns observed in carcinoids suggest different types of secretion of EC-cells; para-, endo- and sometimes-exocrine secretion. Tumor cells produce amines and polypeptide hormones. The functional significance of lipids frequently identified in carcinoids remains to be established. Since endocrine cells at different stages of differentiation and mucus-producing ones occur in the same tumors, it is suggested that both originate from the cambial elements of the epithelial lining of mucous membranes.

Bronchial Neoplasms↗
PubMed1982

[Carcinoid tumor of the mediastinum].

A carcinoid tumor of the mediastinum in a man of 58, incidentally detected at a roentgenological examination is described. Its histological structure was identical with that of carcinoids of other localization. The tumor cells contained argyrophilic granules. The patient died 41/2 years after the operation in the presence of extensive lymphogenic and hematogenic metastases. The authors believe that signs such as cellular and nuclear polymorphism, outgrowth of the tumor cells into the capsule, lymph vessels detectable even in limited area should be considered as criteria of malignancy of the neoplasma and the basis for prescription of radiation and chemotherapy.

Carcinoid Tumor↗
PubMed1981

[Changes in the heart in the carcinoid syndrome].

An observation of carcinoid syndrome in a woman of 47 suffering from malignant carcinoid of the ileum with metastases into the liver and right ovary is described. The clinical picture included diarrhea, heat waves, bronchospasms, hypertension, hyperserotoninemia, affection of the mitral valve and left atrium. "Carcinoid plaques" in the endocardium formed due to excessive proliferation under the influence of serotonin and kinins of polypotent subendothelial cells followed by their differentiation into fibroblast-like and smooth-muscle elements and production of basophilic interstitial substance. The receding rheumatic affection of the mitral valve may be the cause of the predominant involvement of the left part of the heart.

Autopsy↗