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Biomedical subjects

I Rubinstein

Publications and source records attributed to I Rubinstein.

At least 181 records · Page 10Linked to original sources
PubMed1986

Does prolonged use of diphenylhydantoin predispose to pulmonary sarcoidosis?

We describe 3 patients with epilepsy who developed sarcoidosis, stage I, while being treated with diphenylhydantoin for prolonged periods. We are unaware of such an association in the literature. However, in the light of the current knowledge about the adverse immunologic reactions that may be caused by diphenylhydantoin and the altered immunological state described in sarcoidosis, we recommend physicians to look for and report on similar cases in order to assess possible cause and effect relationships between the two.

Adult↗
PubMed1986

Left-ventricular exercise echocardiographic abnormalities in patients with sarcoidosis without ischemic heart disease.

We performed postexercise two-dimensional echocardiography in 21 patients with sarcoidosis but no signs of ischemic heart disease and in 24 normal control subjects. This was done to assess global and regional left-ventricular (LV) function and to try to identify the presence of occult myocardial involvement among sarcoidosis patients. All 21 sarcoidosis patients had a normal resting left-ventricular ejection fraction (LVEF) and echocardiogram. An abnormal LV response to exercise was detected in 10 sarcoidosis patients in the form of a significant decrease in mean LVEF with exercise without concomitant clinical and ECG evidence of myocardial ischemia. Seven of these 10 patients were found to have a pathological increase in LV and systolic volume with exercise, although it did not achieve statistical significance. In addition, markedly abnormal regional septal wall motion was noted in two of these patients. In the remaining 11 sarcoidosis patients, mean LVEF increased significantly with exercise. This is the normal ejection fraction response to stress. These 11 patients also showed that LV end-systolic volume decreased with exercise; the decrease was from 40.8 to 27.9 ml (P = 0.0004). In the control group, the mean LVEF increased from 69.5 +/- 7.2 at rest to 78.5 +/- 7.6 with exercise (P less than 10(-6)). We conclude that postexercise echocardiography is a noninvasive, simple, and safe method to detect and to follow the course of possible occult myocardial sarcoidosis.

Adult↗
PubMed1985

Sarcoidosis: a cause of bilateral hilar lymphadenopathy after excision of malignant melanoma of the arm.

Bilateral hilar lymphadenopathy developed in a patient one year after excision of a malignant melanoma of the left arm. There were no signs of distant metastases. Hilar lymph node biopsy specimen obtained by mediastinoscopy showed multiple noncaseating granulomas consistent with sarcoidosis, without evidence of tumor cells. Sarcoidosis developing in the course of a preexisting neoplasm is rare, but must be considered in order to establish a proper diagnosis and withhold unnecessary treatment.

Adult↗
PubMed1985

Prognosis of patients with adenocarcinoma of the lung and mediastinal lymph node metastases undergoing pulmonary resection.

Of 57 patients who were operated on for adenocarcinoma of the lung during the period 1966-1970, 18 with mediastinal lymph node metastases successfully underwent potentially curative pulmonary resection combined with complete mediastinal lymph node dissection. The 5-year survival rate was nil. In light of this poor outlook, we do not recommend surgery as the primary treatment of choice in patients with adenocarcinoma of the lung and known mediastinal lymph node metastases.

Adenocarcinoma↗
PubMed1985

Sarcoidosis and Hashimoto's thyroiditis--a chance occurrence?

We present a case of pulmonary sarcoidosis associated with Hashimoto's thyroiditis. This association has been reported previously and may be purely coincidental. However, in light of current knowledge about the immunoregulatory defects postulated for sarcoidosis and for Hashimoto's thyroiditis, three other possibilities that may explain this association in our patient, are discussed.

Aged↗
PubMed1985

Autoimmune hemolytic anemia as the presenting manifestation of malignant thymoma.

Severe autoimmune hemolytic anemia is described as the presenting manifestation of malignant thymoma. The hemoglobin level was 5.7 g/dl, the direct IgG antiglobulin test (direct Coombs' test) was strongly positive and the indirect Coombs' test was weakly positive. Prompt remission of the hemolytic process was achieved by thymectomy combined with corticosteroid therapy; the hemoglobin level rose to 12.2 g/dl and both the direct and indirect Coombs' tests became negative. To our knowledge, this is the first case to be described in which autoimmune hemolytic anemia was the presenting manifestation of malignant thymoma. Autoimmune hemolytic anemia may be considered as a manifestation associated with malignant thymoma.

Anemia, Hemolytic, Autoimmune↗
PubMed1985

Isolated malignant lymphoma of the jejunum and long-term diphenylhydantoin therapy.

We report a case of isolated malignant lymphoma of the jejunum occurring 18 18 months after continuous diphenylhydantoin therapy for epilepsy. Although this association may be purely coincidental, we suggest a possible causal relationship between the two in light of current knowledge about the immunological aberrations that may be caused by prolonged administration of diphenylhydantoin in man.

Aged↗
PubMed1985

Asymptomatic pulmonary nodule in sarcoidosis.

A case of an asymptomatic solitary pulmonary nodule which proved to be due to sarcoidosis, is described. Only an excisional biopsy can establish the diagnosis. Sarcoidosis, although rare, must be added to the differential diagnosis of asymptomatic solitary pulmonary nodule.

Adult↗