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Biomedical subjects

I Rossi

Publications and source records attributed to I Rossi.

67 records · Page 4Linked to original sources
PubMed1978

Visualization of the areae gastricae in a double contrast examination - dependence on the contrast medium.

Visualization of the areae gastricae, a criterion of high resolution in the double contrast examination of the stomach, was studied with several barium preparation. Visualization of the areae gastricae varied among different contrast media, some gave excellent visualization while others were regularly inadequate. In general, contrast suspensions prepared from powder in the X-ray department gave better results than commercial suspensions, which retained many gas bubbles. The importance of the contrast medium selection for a high resolution double contrast examination of the stomach is emphasized.

Barium Sulfate↗
PubMed1978

Effect of glucagon on the double contrast examination of the stomach and duodenum.

We have evaluated the effect of glucagon on the quality of visualization of the gastric and duodenal mucosa in a routine tubeless double contrast examination of 418 consecutive cases. The patients received either 0.5 mg i.v., 0.25 mg i.v. or no glucagon, at radom. The use of glucagon improved the visualization of areae gastricae and produced slightly fewer gas bubbles in the stomach. Visualization of the duodenum was significantly improved. The frequency of adequate hypotonic duodenography was related to the dose of glucagon, with 0.5 mg it was achieved in 49% of cases. No side-effects ascribable to glucagon were observed. The routine use of a small i.v. dose of glucagon in double contrast studies is recommended.

Adult↗
PubMed1977

Mitochondrial functions and content of microsomal and mitochondrial cytochromes in human cirrhosis.

1. Mitochondria and microsomal fractions have been isolated from liver biopsies from patients with alcoholic cirrhosis, cryptogenic cirrhosis or chronic aggressive hepatitis. 2. Cirrhotic livers yieled fewer mitochondria than normal liver. 3. The most significant change was a decrease in mitochondrial respiratory control. Cirrhotic microsomal fractions had a 50% diminution in cytochrome b5 and cytochrome P-450 content. 4. The two patients with chronic aggressive hepatitis showed similar mitochondrial and microsomal changes.

Adult↗
PubMed1975

[Clinical test of the Delcomat miniaturisation system (author's transl)].

A series of 1720 roentgen examinations consisting of 5178 roentgen films were copied with the Delcomat (de Oude Delft) copying apparatus. The copies were re-examined after some months, and the diagnoses were compared with the original ones made of normal size films. The diagnostic accuracy was in most examinations not significantly reduced. There was some extraneous variation not depending on the copying method in complicated pulmonary and cardiologic problem cases, and the lack of immediate screening information also caused some reduction in the diagnostic accuracy. The presumption that there would be some information loss in the miniaturized copies led to false positive statements in some cases. The diagnoses were made by a group of radiologists consisting of one specialist (staff member) and two registrars (residents).

Clinical Trials as Topic↗
PubMedDate not supplied

Protein structure prediction and biomolecular recognition: from protein sequence to peptidomimetic design with the human beta3 integrin.

Computational tools can bridge the gap between sequence and protein 3D structure based on the notion that information is to be retrieved from the databases and that knowledge-based methods can help in approaching a solution of the protein-folding problem. To this aim our group has implemented neural network-based predictors capable of performing with some success in different tasks, including predictions of the secondary structure of globular and membrane proteins, the topology of membrane proteins and porins and stable alpha-helical segments suited for protein design. Moreover we have developed methods for predicting contact maps in proteins and the probability of finding a cysteine in a disulfide bridge, tools which can contribute to the goal of predicting the 3D structure starting from the sequence (the so called ab initio prediction). All our predictors take advantage of evolution information derived from the structural alignments of homologous (evolutionary related) proteins and taken from the sequence and structure databases. When it is necessary to build models for proteins of unknown spatial structure, which have very little homology with other proteins of known structure, non-standard techniques need to be developed and the tools for protein structure predictions may help in protein modeling. The results of a recent simulation performed in our lab highlights the role of high performing computing technology and of tools of computational biology in protein modeling and peptidomimetic design.

Databases, Factual↗