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Biomedical subjects

I Rosenfeld

Publications and source records attributed to I Rosenfeld.

14 recordsLinked to original sources
PubMed2006

Models for estimating digesta passage kinetics in the gastrointestinal tract of the horse.

Fecal samples were collected to evaluate mathematical models to describe the kinetics of digesta passage in the segments of the equine gastrointestinal tract and to compare the passage kinetics of hay and oats. Four Norwegian Cold-blooded trotters (cecally cannulated, approximately 500 kg of BW) were fed Cr-mordanted hay and Yb-marked oats with their morning meal. The meal consisted of 2 kg of hay and 1 kg of oats processed as ground, pelleted, extruded, or micronized. Each horse was fed each type of oats on different days of collection, after a 5-d adaptation period, in a 4 x 4 Latin square design. Fecal samples were collected 5, 6, 7, 8, 9, 10, 11, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 48, and 52 h after administration of the marker dose. The samples were analyzed for Cr and Yb, and values were plotted using 1- and 2-compartment nonlinear passage models and an algebraic model. The 1-compartment G4 model and the 2-compartment G4G1 model showed an equally good fit to the observed excretion curves, based on low mean square error and SE. The excretion curves for hay (Cr) and oats (Yb) showed a striking similarity, and there seemed to be no difference in retention time between hay and oats in the horse. The mixing compartments in the horse are believed to be the cecum or both the cecum and the right ventral and dorsal segments of the colon, but further research in this area is needed to make a final conclusion.

Animal Feed↗
PubMed2001

The significance of malignancies incidental to microcalcifications in breast spot localization biopsy specimens.

BACKGROUND: Incidental breast cancer is occasionally found in spot localization biopsy specimens adjacent to mirocalcifications in benign breast disease. Because this phenomenon could prove problematic for percutaneous sampling of microcalcifications without excisional biopsy, we studied surgical specimens from patients with cancers incidental to microcalcifications and compared them with specimens with microcalcifications within the malignancy. METHODS: The pathology database at the Mount Sinai Medical Center from January 1993 to July 1998 was reviewed to identify breast cancer patients who underwent spot localization biopsy for microcalcifications. Patients presenting with microcalcifications within malignancy (determinate) were compared with patients with mirocalcifications in benign breast tissue adjacent to malignancy (incidental). RESULTS: Thirty-two (13%) of the 241 specimens had microcalcifications in benign tissue adjacent to malignancy and 209 (87%) had microcalcifications within the malignancy. Fifty-six percent of the incidental cases and 65% of the controls had ductal carcinoma in situ. Infiltrating lobular carcinoma accounted for 25% of the incidental cancers and 2% of the determinate cancers (P <0.001). Fifty-seven percent of the infiltrating carcinomas incidental to mammographic findings were infiltrating lobular carcinoma compared with 7% of the nonincidental infiltrating carcinomas. None of the incidental invasive carcinomas were poorly differentiated (P = 0.002). There were no significant differences with regard to age, tumor size, stage, differentiation, estrogen and progesterone receptors, type of surgery and final margin status. In none of the patients with incidental malignancies did local or distant recurrences develop. CONCLUSIONS: Incidental carcinomas were found in 13% of spot localization biopsy specimens obtained for suspicious mammographic microcalcifications and have a favorable prognosis. Infiltrating lobular carcinomas are more commonly found with incidental microcalcifications than with determinate microcalcifications, and incidental invasive carcinomas are less likely to be poorly differentiated. The majority of malignancies, both determinate and incidental to microcalcifications, are due to ductal carcinoma in situ. Incidental malignancies commonly occur adjacent to fibrocystic changes and their other pathologic characteristics are not significantly different from nonincidental carcinomas. Despite the absence of radiographic findings, these patients can be successfully treated with breast conservation.

Biopsy↗
PubMed1982

Myocardial free-wall rupture after acute infarction: survival aided by percutaneous intraaortic balloon counterpulsation.

After his first acute myocardial infarction, a 69-year-old male suffered the usually lethal complication of ventricular free-wall rupture. Early suspicion of possible rupture and immediate percutaneous insertion of an intraaortic balloon pump assist device afforded sufficient hemodynamic stability to proceed with cardiac catheterization. The diagnosis of ventricular free-wall rupture was confirmed and the extent of coronary artery disease defined. The patient underwent repair of the free-wall rupture and coronary artery bypass grafting and has returned to full activity.

Aged↗
PubMed1975

National health planning in the United States: prospects and portents.

The National Health Planning and Resources Development Act of 1974 in the United States demonstrates a growing determination in Congress to motivate the system of health services toward greater efficiency in utilization of resources. The Act was designed to overcome some of the weaknesses in earlier planning legislation. More complete coverage and more functional local jurisdictions for planning should result. The Act provides better financial support, and more effective incentives and inducements to assure adherence to plans. Concern is expressed about aspects of the legislation which the authors feel may deserve consideration. The principle of delegating responsibility to voluntary agencies for disbursement of public funds is questioned, and the authors suggest that local public health authorities apply for designation as planning agencies. Reservation is expressed about the adequacy of regional organization as provided by the Act to accomplish its purposes, and the authors recommend demonstrations of regional administrative agencies to implement plans developed by Health Systems Agencies. Failure to incorporate the provision of the House planning bill to set up a national health policy council in the Act is considered unfortunate. Persistence in pursuing the course outlined in the Act is urged.

Financing, Government↗
PubMedDate not supplied

Stress X-rays and the low back pain patient.

This study was undertaken to determine if demographic, historical and/or clinical information would be helpful in predicting the presence of abnormal motion depicted on a stress radiograph (flexion, extension and lateral bending views). A total of 72 patients were divided into "normals" and "abnormals" based on the presence of abnormal sequential intersegmental vertebral motion as demonstrated on the stress radiographs. Demographically and historically, the "normal" and "abnormal" groups were essentially the same. Clinical data also failed to show any statistically significant differences between the two groups. Other radiographic findings (scoliosis, degenerative disease, and foraminal encroachment) did not show any significant differences. The value of demographic, historical and/or clinical information as input into the formulation of a protocol for stress radiography is questioned. Suggestions for further research are given.

Back Pain↗