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Biomedical subjects

I Reuter

Publications and source records attributed to I Reuter.

31 records · Page 2Linked to original sources
PubMed1998

Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL.

TRANSFAC, TRRD (Transcription Regulatory Region Database) and COMPEL are databases which store information about transcriptional regulation in eukaryotic cells. The three databases provide distinct views on the components involved in transcription: transcription factors and their binding sites and binding profiles (TRANSFAC), the regulatory hierarchy of whole genes (TRRD), and the structural and functional properties of composite elements (COMPEL). The quantitative and qualitative changes of all three databases and connected programs are described. The databases are accessible via WWW:http://transfac.gbf.de/TRANSFAC orhttp://www.bionet.nsc.ru/TRRD

Animals↗
PubMed1998

[Stretching--do current explanatory models suffice?].

The opinion that mobility in the usual performance if the "straight leg raise" test for the evaluation of stretching techniques is subject to solety muscular limitations is critically appraised. With integration of recent results from molecular biological research and our own measurements, we can show that not only mechanical but also neurophysiological factors must be considered in the limitation of mobility. In the majority of the examined patients stretching of the ischiadic nerve seems to be responsible for restrictions in movement. The presented results cast doubt on the currently held assumptions and basic principles of stretching in therapy and sport.

Adult↗
PubMed1998

Transcription regulatory region analysis using signal detection and fuzzy clustering.

MOTIVATION: Presently available programs for the recognition of potential transcription factor binding sites in genomic sequences generally yield a huge amount of output. These output lists have to be filtered to obtain biologically significant elements, which is highly laborious work to be done manually. RESULTS: We developed a strategy for systematic verification and improvement of the underlying profiles, and for their contextual analysis by a fuzzy clustering approach using non-redundant libraries of search profiles as a prerequisite. AVAILABILITY: The tools mentioned in the paper are available upon request. CONTACT: ewi@gbf.de

Algorithms↗
PubMed1998

Creatine supplementation in endurance sports.

PURPOSE: Creatine is a physiologically active substance indispensable to muscle contraction. The increase in creatine phosphate obtained by supplementation is greater than the increase in total creatine achieved by specific sports training. Less well-trained people can produce an immediate energy store when supplementing creatine such as is otherwise achieved by top athletes on normal nutrition by means of speed and power training. The publications so far available indicate that creatine accumulation in muscle was accomplished using relatively high doses (20 g daily over 5 d). The objective of our study was to investigate the alterations in creatine and creatinine concentrations following lower dosages. METHODS: As intermediate and finishing spurts under anaerobic conditions are gaining in importance in endurance sports, we created a special exercise test for triathletes combining endurance and interval performance. After a pretreatment exercise test was performed, the athletes ingested 6 g of creatine daily, divided into two portions for 5 d. On day 6, another exercise test was performed. RESULTS: Creatine supplementation was found to have no influence on the cardiovascular system, oxygen uptake, and blood lactate concentration. The fall in blood glucose during the exercise test was significantly reduced after consumption of creatine. Although interval power performance was significantly increased by 18%, endurance performance was not influenced. CONCLUSIONS: We conclude that creatine supplementation at doses of 6 g daily has positive effects on short-term exercise included into aerobic endurance exercise.

Administration, Oral↗
PubMed1997

[Spondylolysis and spondylolisthesis and sports].

Spondylolysis and spondylolisthesis occur predominantly in the lower lumbar spine. Besides congenital defects such as predisposition of spondylolysis the correlation between competitive sports activities and an increased incidence of spondylolysis is proved. In early stages, complete healing can be achieved by conservative treatment (abstinence from sports activities for 3 months, orthesis). Persistence of pain, neurologic symptoms and progression of vertebral slipping are indications for operative treatment (reconstruction of the isthmus, dorso-ventral spondylodesis). The exercise tolerance depends on the extent of instability, progression of vertebral slipping and clinical symptoms. The limits of exercise tolerance vary among the individual athletes and require the decision of the physician. Backstroke swimming, abdominal and back muscle strengthening exercises, and types of sport involving smooth movements are advisable. Sports education in school is possible without restriction in patients with stable spondylolysis and in those with spondylolisthesis without unfavourable concomitant factors.

Adult↗
PubMed1997

[The nerve supply of the knee joint].

The paper presents the present state of research on the most important receptors of joints and muscles with regard to occurrence, structure, and function. Proprioception relies on the nervous supply of the tissues in the knee joint, and on the surrounding muscles and tendons; it is the basis of coordination.

Afferent Pathways↗
PubMed1997

[Therapeutic physical training after knee injuries].

Exercise training is a therapy that accompanies and follows physiotherapy. Basic training principles are discussed on the basis of motricity research. Initially, exercise therapy mostly trains patients to recall and standardize the execution of exercise programs. With the patient's increasing power of endurance, the intensity of extent of training are increased. Exercise therapy eventually aims at particularly preparing the patient for the activities of daily living and the sportsman for the requirements specific to training and competition.

Combined Modality Therapy↗
PubMed1994

Artificial bone erosions: detection with magnification radiography versus conventional high-resolution radiography.

PURPOSE: To compare the diagnostic performance of direct magnification radiography with computed radiography versus that of conventional radiography in detection of artificial bone erosions. MATERIALS AND METHODS: Thirty-one paws from German shepherd dogs were embedded in paraffin and examined with x6 magnification radiography and conventional radiography before and after creation of artificial bone erosions. A microfocal x-ray unit with a focal spot of 20-130 microns was used for magnification radiography. All 210 images were analyzed by five radiologists, and receiver operating characteristic (ROC) analysis was performed. Interobserver analysis in evaluation of anatomic structures was also performed. RESULTS: ROC analysis of pooled data from all readers showed a larger area under the ROC curve for magnification radiography (0.88) than for conventional radiography (0.72). Magnification radiography produced higher scores in interobserver analysis as well. CONCLUSION: Magnification radiography is superior to conventional radiography in detection of small bone erosions.

Animals↗
PubMed1991

[Direct radiographic magnification in dental radiology].

Panography using small focal spots was an accepted radiodiagnostic method in dentistry before it was replaced by pantomography. Meanwhile, a new microfocus X-ray tube with a much smaller focal size is available. In comparison with the former focal system no new aspects are discernible. On the other hand, the new tube will be especially helpful for preparative diagnostic work before histological evaluations.

Humans↗
PubMed1976

[Reflections on the anorectal pressure profile].

The results of electromanometric studies of the anorectum in 40 children are presented. Owing to a constant flow of rinsing water through the recording tube and owing to a repeated tracing during the same session, there is a more sensitive picture of the anorectal pressure profile than reported hitherto. In addition, the anorectal pressure values are higher. In healthy infants and in most children with constipation and/or encopresis, the anorectal pressure profile can be divided in 2 different parts. These can be differentiated by their amplitude and according to their shape. In a few patients with constipation, there is no difference between the two parts concerning the shape of the anorectal pressure profile, and the values of the anorectal pressures are below normal. But all children with anal sphincter incontinence have a distinctively abnormal anorectal pressure profile, there is not even a numerical difference between the two parts of the anorectal pressure profile, and the anorectal pressures are very low. The relationship between these two parts of the anorectal pressure profile and the muscles of the pelvic floor are discussed and the significance of the mentioned technique evaluated with regard to the diagnosis and treatment of the anorectal disturbances in childhood.

Anal Canal↗