Ophthalmic manifestations of childhood leukaemia.
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Child↗
Biomedical subjects
I Rennie
Publications and source records attributed to I Rennie.
A prospective study of oral Nadolol in the management of patients with newly diagnosed chronic simple glaucoma.
Thirty patients with newly diagnosed chronic open angle glaucoma were initially treated with once daily oral Nadolol at a dose of 20 mg. This was increased to 40 mg where control was considered inadequate. Topical therapy was then added as necessary if control was still not maintained. Significant decreases in intra-ocular pressure (IOP) were achieved with a dose of 20 mg, but there was no significant further reduction when the dose was increased to 40 mg. One patient was controlled throughout the study period with 40 mg Nadolol daily and 4% Pilocarpine four times daily. At best, only temporary control was achieved in the remaining 29 patients. Intra-ocular pressures were measured 24 hours after the previous dose of Nadolol in 13 patients who were controlled for a minimum of 1 month on Nadolol alone and then again 3 hours after their normal dose. Control of IOP was lost in all patients at 24 hours pre-dose but was regained by 3 hours post-dose. Four patients were withdrawn because of mild side effects attributable to the beta-blocking action of Nadolol. The treatment regime used in this study was ineffective at controlling the IOP in the group of patients studied. A once daily regime of Nadolol does not control IOP over a full 24 hours.
Administration, Oral↗
Haemangioma of the optic disc.
Isolated capillary haemangiomata of the optic disc are uncommon; they may be associated with the von Hippel-Lindau syndrome. Renal carcinoma occurs in almost one-third of patients with this condition, and it may go unnoticed until metastases occur. Early nephrectomy offers a cure. It is important, therefore, that all patients with optic disc capillary haemangiomata as well as their relatives are referred for screening for the stigmata of this disease.
Adult↗
External ocular pigmentation secondary to perforating eye injury.
The dispersal of pigment centrifugally through the conjunctiva from the site of a repaired traumatic perforation was observed. Iris tissue had been incarcerated in the wound for three days prior to surgical repair. Conjunctival biopsies were examined by light and electron microscopy. Light microscopy revealed a normal, non-pigmented conjunctival epithelium and numerous pigment-laden cells in the substantia propria. Electron microscopy showed these cells to contain melanosomes closely resembling those found in normal iris posterior pigment epithelium. The causes of abnormal external ocular pigmentation are discussed.
Conjunctival Diseases↗