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Biomedical subjects

I Reisinger

Publications and source records attributed to I Reisinger.

10 recordsLinked to original sources
PubMed1998

Somatostatin receptor scintigraphy in small-cell lung cancer: results of a multicenter study.

UNLABELLED: The aims of this study were to determine the accuracy of somatostatin receptor scintigraphy in the detection of the primary tumor and its metastases in small-cell lung cancer (SCLC) in a large patient population, and to investigate the course of somatostatin uptake in primary tumors during therapy. METHODS: In a total of 100 patients, 134 examinations were performed. Twenty-seven of the patients were examined before and after chemotherapy. Planar whole-body images were acquired 4 hr and 24 hr after injection of approximately 200 MBq (111)In-pentetreotide. SPECT of the thorax was performed after 24 hr. Tumor-to-background (T/B) ratios for the primary tumor were averaged from anterior and posterior projections. RESULTS: Compared to conventional investigations, somatostatin receptor scintigraphy (SRS) visualized the primary tumor with varying degrees of uptake in 96% of the examinations. Regional metastases and distant metastases were detected in 60% and 45% of the examinations, respectively. The uptake of the somatostatin analog by the primary tumor was significantly lower in the patients examined during chemotherapy as compared to those examined before treatment (T/B ratio = 1.94+/-0.79 versus 2.35+/-0.9, p < 0.005). A decrease in T/B ratio was noted in patients with remission at the time of SRS (from 2.40+/-1.56 to 1.63+/-0.72, p < 0.05). No difference in the pretreatment uptake of octreotide by the primary tumor was identified between patients with tumor progression and those with partial or complete remission. CONCLUSION: Somatostatin receptor scintigraphy has a high sensitivity in the detection of the primary tumor in SCLC but fails in the detection of metastases. Thus, SRS does not provide useful information for staging of SCLC. Since somatostatin uptake by the primary tumor is affected by chemotherapy, it may be used to follow up on the course of SCLC.

Adult↗
PubMed1994

Biochemical diagnosis in prenatal uropathy.

Thirty-two fetuses, six with prune-belly syndrome, seven with renal cyst, 19 with obstructive uropathy, underwent intrauterine fluid aspiration during weeks 15-37 of gestation. Fluid samples were analysed for Na, K, creatinine, urea, alpha 1-, and beta 2-microglobulin. Aspirate concentrations of sodium below 130 mmol/L and creatinine above 115 mumol/L indicate an active kidney and exclude a renal cyst. However, aspirates from fetal cysts or fetuses with obstructive uropathy showed analyte concentrations for sodium, potassium, creatinine, and urea corresponding to extracellular fluid (ECF). In conclusion fluid aspirates of fetuses with ultrasonographically detectable cystic cavities in the abdomen should be examined for sodium and creatinine to assess remaining renal function for planning of obstetric management.

Alpha-Globulins↗
PubMed1988

Antiinflammatory effect of a lipoxygenase inhibitor (FLM 5011) in severe active myocarditis.

FLM 5011 belongs to a group of chemical compounds with isolated lipoxygenase products in human polymorphonuclear leukocytes and alveolar macrophages. FLM 5011 has been shown to be protective against arachidonic acid-induced bronchoconstriction in vitro and in vivo. No severe side-effects were found in extensive tests on acute and subchronic toxicity in animals. In preliminary investigations on patients with severe active myocarditis impressive clinical and histological improvements after administration of FLM 5011 have been obtained, suggesting an antiinflammatory effect of the substance. A follow-up of more than 13 months compared with conventional immunosuppressive therapy indicates potential therapeutic value of this compound on the inflamed myocardium.

Adult↗
PubMed1988

[Noninvasive examination methods in the detection of right heart hypertrophy in children with mucoviscidosis].

Pulmonary hypertension with right ventricular hypertrophy (Cor pulmonale) is a critical complication in cystic fibrosis patients. Early detection and therapy might decrease mortality. Noninvasive diagnostic methods as vector-ECG, m-mode echocardiography and thallium myocardial scintigraphy were performed in 50 children with cystic fibrosis to determine the degree of right ventricular hypertrophy.

Adolescent↗
PubMed1983

[Acute myocardial infarction in patients over 70].

History and clinical course were studied in 299 patients with acute myocardial infarction. 133 patients aged 70 and older (group 2) were compared to 166 patients under 70 (group 1). Hospital mortality of the total group was 23%. The mortality rate among the older patients (31%) was significantly higher than among the younger patients (17%) (p less than 0.01). The major cause of death in both groups was cardiogenic shock. It is noteworthy that in eight cases from group 2 pulmonary embolism was diagnosed at autopsy in spite of the fact that the patients were receiving prophylactic antithrombotic therapy. Analyzing the histories, it was noticed that group 2 had a significantly higher percentage of hypertension and left heart failure, whereas in group 1 significantly more smokers and hyperlipidemics were found. During hospitalization left ventricular enlargement and insufficiency were diagnosed more often in the elderly. It may be assumed that this fact is one of the reasons for the increased mortality of group 2.

Adult↗