Biomedical subjects
Publications and source records attributed to I Regev.
Reserpine- and propranolol-treated rats were given salbutamol, a beta-adrenergic stimulant, intra-peritoneally in an open control study. The results suggest that salbutamol has a therapeutic effect on the depressive behavior of reserpine- and propranolol-treated rats.
A 56-year-old man had acute onset of left sided weakness, spontaneous pain and hyperpathia in the left limbs. CT demonstrated a small pontine haemorrhage, in the floor of the fourth ventricle.
Antidepressant drug overdoses have been reported to induce seizures, but the etiology of this phenomenon is still unclear. Recently we treated three patients who suffered from epileptic seizures after acute overdoses of three antidepressant drugs: (a) Dibenzepin HCl (Noveril), (b) Maprotiline HCl (Ludiomil), and (c) Clorimipramine (Anafranil). After a review of the pertinent literature, the possible role of antidepressant drugs in the genesis of epileptic seizures is discussed.
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The antiparkinsonian activity of several dopamine agonists was investigated in an animal model and clinically in parkinsonian patients. The semisynthetic ergoline, pergolide, the partial ergoline, LY 141865 and the 8-alpha-aminoergoline, CU 32-085 were found to be effective antitremor agents in monkeys with ventromedial tegmental lesions. The administration of pergolide or LY 141865 results in a relief of tremor with a concomitant occurrence of severe abnormal involuntary movements, while the administration of CU 32-085 results in a relief of tremor with the occurrence of only minor abnormal involuntary movements. Clinical studies have revealed that pergolide is an effective drug in patients with advanced Parkinson's disease, and it reduces the "on-off" phenomena. The possible regulation of dopamine neurotransmission by the norepinephrine neuronal systems was reviewed. Preliminary data suggest that clonidine may interact with presynaptic dopamine receptors.
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CSF samples of hypertensive and normotensive matched groups were assayed and compared for renin activity (RA). The measurements yield low values of RA in both groups without significant difference between them. There was no correlation between the CSF level of RA of each patient and his own concomitant plasma renin activity (PRA). Although the presence of RA in the CSF was confirmed in this study, no direct correlation seems to exist between it values and the elevated blood pressure; therefore, the pathophysiological significance of the renin-angiotensin system in the CSF and its relation to centrally generated hypertension remains questionable.
The activity of DBH enzyme was measured in plasma of 7 non treated patients suffering from Parkinson's disease; a 10 mg dose of Bromocryptine was administered per os to these patients. Attained results were compared to the enzyme activity in a group of control of 7 healthy individuals. It was pointed out that in patients suffering from Parkinson's disease the decrease of DBH level in plasma after the administration of Bromocryptine was of 32.6% +/- SE 4.4% while in the group of control the decrease was only of 15% +/- SE 4.9%. This decrease in the plasmatic level of the enzyme after the administration of Bromocryptine should be due to the marked antagonistic activity of Bromocryptine on pre-synaptic dopaminergic receptors. This should mean that peripheric pre-synaptic dopaminergic receptors are involved in the physiopathology of Parkinson's disease.