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Biomedical subjects

I R Neering

Publications and source records attributed to I R Neering.

29 records · Page 2Linked to original sources
PubMed1976

Relationship between vasoconstriction and histamine induced vasodilation.

Histamine produced significantly greater vasodilation in rabbit ear arteries constricted by noradrenaline than when the same arteries were constricted by either caffeine or barium. Histamine dilation in the presence of caffeine was also significantly greater than that in the presence of barium. These results suggest that histamine may produce vasodilation through at least two different modifications of intracellular calcium mobilisation.

Animals↗
PubMed1969

Sustained complete autonomic blockade.

1. A 3-hr period of complete autonomic blockade was induced in anaesthetized sheep and dogs using a continuous intravenous infusion of trimetaphan camphorsulphonate and atropine. Circulatory, respiratory and metabolic parameters were studied over 24 hr or until the animal died, whichever came first.2. After termination of the blockade all animals remained hypotensive and within a few hours all died in irreversible shock which was not accompanied by any of the otherwise characteristic respiratory or metabolic consequences of circulatory failure.3. Administration of trimetaphan alone for a similar period was innocuous.4. When during complete autonomic blockade a continuous infusion of dopamine or hypertensin was additionally administered mortality rate was halved but all survivors remained hypotensive.

Angiotensin II↗
PubMedDate not supplied

Role for microsomal Ca storage in mammalian neurones?

Alterations in the intracellular concentration of calcium ions [( Ca2+]i) are increasingly being found to be associated with regulatory functions in cells of all kinds. In muscle, an elevation of [Ca2+]i is the final link in excitation-contraction coupling while at nerve endings and in secretory cells, similar rises in [Ca2+]i are thought to mediate exocytosis. The discovery of calcium-activated ion channels indicated a role for intracellular calcium in the regulation of membrane excitability. Calcium transients associated with either intracellular release or the inward movement of Ca2+ across the membrane have been recorded in molluscan neurons and more recently in neurones of bullfrog sympathetic ganglia. Here, we report the first recordings of calcium transients in single mammalian neurones. In these experiments we have found that the methylxanthine, caffeine, causes the release of calcium from a labile intracellular store which can be refilled by Ca2+ entering the cell during action potentials.

Animals↗