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Biomedical subjects

I Préda

Publications and source records attributed to I Préda.

10 recordsLinked to original sources

Surface potential distribution on the human thoracic surface in left bundle branch block.

The sequences of myocardial excitation in the cases of human LBBB have been studied by the surface mapping technique. Analysis of the surface map patterns of 12 subjects has enabled 4 different types to be described. It is suggested that Type I represents a complete LBBB in the presence of an intact right bundle branch, while Types II and III show different degrees of conduction defect in the right bundle branch, too. The left ventricular activation of these 3 types has a similar pathway in phases II and III which is determined by orientation of the main subepicardial muscle layer coursing through the apex and terminating in the anterobasal region. The terminal anterobasal activation in the cases of LBBB has not only theoretical, but clinical significance, since in the presence of anteroseptal myocardial infarction the signs of necrosis must be hidden not in the early, but in the terminal parts of the QRS complex of conventional ECG. The lack of terminal anterior positivity of surface maps in the case of LBBB may be indicative of chronic anterior myocardial infarction.

Bundle-Branch Block

The role of potassium-canrenoate on 3H-noradrenaline uptake and metabolism of the rat heart.

The influence of potassium-canrenoate (structurally related to spironolactones) on noradrenaline (NA) uptake and metabolism of the heart was studied in normal and hypopotassaemic rats. In normal rats spironolactone administration resulted in a marked increase of 3H-NA uptake in both the atrial and the ventricular tissues, but the NA content was unchanged. An increased myocardial NA uptake in the presence of an unchanged content suggested an increased rate of NA turnover under the influence of spironolactone. In saluretic pretreated animals, spironolactone normalized both the previously decreased NA uptake and the low intracellular potassium level of the heart tissue. The augmentation of catecholamine metabolism due to spironolactone may be involved in enhanced activity of adenyl cyclase and forms the basis of the compounds positive inotropic effect.

Animals

Myocardial noradrenaline uptake after coronary occlusion in the rat.

Coronary ligation produced a marked increase in labelled noradrenaline uptake by the myocardial tissue of rats. The peri-ischemic zones showed an elevated accumulation of noradrenaline on the 4th day but the intact zone had returned to normal values. At the 14th day of observation, both the ischemic and per-ischemic tissue exhibited a subnormal accumulation of radioactivity. The role of the acidotic state in the changes of noradrenaline uptake was studied in vitro. Noradrenaline accumulation in the myocardial tissue was higher at pH 6.8 than at 7.4 or 7.1 Competition studies revealed that unlabelled noradrenaline had occupied the binding sites in the same quantity at pH 6.8 and at 7.4. It is assumed that intracellular acidosis was involved in the enhanced accumulation of noradrenaline in the damaged myocardium, and that an increase of noradrenaline concentration in the myocardium may be considered a risk factor in supporting heart function.

Animals