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Biomedical subjects

I Petri

Publications and source records attributed to I Petri.

At least 37 records · Page 2Linked to original sources
PubMed1985

Late malignant transformation of chronic corrosive oesophageal strictures.

The number of patients with scar carcinoma of the oesophagus developing on the basis of a corrosive stricture seems to have been rising in the past two decades. 36 patients of this kind were treated surgically between 1965 and 1984; this is the second largest series in the literature. The patients with scar cancer comprised 7.2% of the overall oesophageal carcinoma cases; this ratio is currently the highest of all in the literature. The interval between the caustic burn and the diagnosis of scar carcinoma was found to be 46.1 years; this is higher than the 30-35 years generally accepted so far. It was 50.9 years in those patients who drank lye before the age of 12, but 14 years less when it happened in adulthood. The long-term survival time proved to be excellent: 45.6% of the resected cases were alive after 5 years and 14.4% after 10 years. The explanation of the good prognosis lies in the fact that carcinoma developing in a lye stricture is at first surrounded by a rigid scar which allows only its intraluminal growth, and it causes early dysphagia through luminal obstruction. Early dissemination is prevented for the same reason. One-stage resection and replacement is suggested in the radically operable cases. In patients with oesophageal corrosive stricture which needs operation, both a by-pass procedure and resection can be adopted, but it should be pointed out that malignancy may develop even years after the operation in the remaining part of the gullet. Total oesophagectomy is therefore suggested instead of bypass.

Burns, Chemical↗
PubMed1985

Steroid sensitivity of chronic uraemic and renal transplant patients measured by the antibody dependent cellular cytotoxicity reaction.

The steroid (methylprednisolone) sensitivity of chronic uraemic and renal transplant patients was examined on the basis of the extent of inhibition of the antibody-dependent cellular cytotoxicity (ADCC) reaction, and via the effect on the ADCC capacity test (ADCC-C). Individuals with an inhibition of 30% or more were classified as steroid-sensitive. Immunopharmacological tests and the clinical picture showed 67%, 12 of the 18 renal transplant patients to be steroid-sensitive. In 92% of the cases the transplanted kidney was functioning well one year or more postoperatively. In 5 of the 6 steroid-resistant patients rejection necessitated removal of the transplanted kidney. The method is simple to perform and gives reproducible results, and appears suitable for application in clinical practice.

Adolescent↗
PubMed1985

Changes in the tendency of lymphocytes to undergo blastic transformation in the postoperative period, in immune-stimulated and untreated colonic tumour patients.

A study was made of the blastic transformation of lymphocytes in the postoperative period in colonic tumour patients: 23 who had been immune-stimulated by vaccination, and 28 who had not been vaccinated. The immune reactivity decreased significantly in the majority of the cases; however, the deterioration of the immune status affected 68% of the nonvaccinated group, but only 48% of the vaccinated group. The data indicate that the vaccination primarily averted the deterioration of the defence ability in the early postoperative period in patients with a normal preoperative immune activity. An evaluable change in the immune reactivity did not occur in the 6-10 preoperative days following vaccination. Three months postoperatively, the number of patients giving a normal immune reaction was three-fold in the vaccinated than in the non-vaccinated group.

Colonic Neoplasms↗
PubMed1985

An in vitro steroid sensitivity test: antibody-dependent cellular cytotoxicity (ADCC) reaction of peripheral lymphocytes in children with nephrotic syndrome.

A steroid effect is described that can be measured in vitro; this was determined by means of the antibody-dependent cellular cytotoxicity (ADCC) method. Examinations on 15 children with nephrotic syndrome revealed a significant correlation between the steroid sensitivity measured in vitro and the clinical sensitivity to prednisolone. The in vitro measurement of steroid sensitivity yielded fast and reliable information on the effectivity of prednisolone treatment.

Antibody-Dependent Cell Cytotoxicity↗
PubMed1984

Thermodynamical model of indefinite mixed association of two components and NMR data analysis for caffeine-AMP interaction.

This paper describes the model used to estimate the parameters of caffeine-AMP interactions from corresponding 1H-NMR measurements and some methods of data analysis by which the applicability of the model has been checked. The model of mixed association is applicable to a mixture of any two substances A and C which exhibit indefinite aggregates in both self-association and mixed association. In aggregates, only nearest neighbour interaction is assumed. The model is described by three equilibrium constants: Kaa and Kcc (for self-association of A, or C, respectively), and Kac (for mixed association).

Journal Article↗
PubMed1984

Thermodynamical model for insertion and aggregate binding of caffeine to the homopolymer poly(riboadenylate) and model choice by data analysis.

This paper describes the model used to estimate the parameters of caffeine-poly(riboadenylate) (poly(A)) interactions from corresponding 1H-NMR measurements. The model of insertion and aggregate binding describes the non-cooperative insertion of a molecule C into an interspace between two monomers of a homopolymer in competition with aggregate binding. It contains two binding constants, K1 for insertion and K2 for the interaction of monomeric A units of the polymer with C molecules in bound aggregates, and two cooperativity parameters, Kcc for stacking of C molecules within aggregates and tau which is thought to be due to conformational adaptation of the polymer to those bound aggregates which cover more than one A unit. In contrast to other models, the size of a binding site (within the aggregates) is less than one monomeric unit, with n denoting the maximum number of C molecules per A unit in bound aggregates. The model is developed for general n by means of the method of sequence-generating functions. For n = 2 and n = 3, the correctness of the model treatment was checked by the matrix method. The model is applicable to the binding of aggregates to homopolymers, which are flexible enough to fit their structure to the aggregates.

Journal Article↗
PubMed1984

Monitoring of suppressor cell activity in nine renal transplant patients.

Function of Concanavalin A generated suppressor cells was serially tested on lymphocytes stimulated by mitogens, by a pool of test cells different in HLA-ABC and -DR, and by the kidney donor's cells preserved in liquid nitrogen. In six patients whose lymphocytes had strong suppressor cell activity, the kidney had a good function for 17-28 months (up to the time of the survey). In three patients who had practically no suppressor cell activity before and after transplantation, each kidney was rejected within 2-3 months. These observations are in accordance with recent experimental and clinical studies of other authors supporting the importance of suppressor cell activity in transplantation tolerance.

Humans↗
PubMed1983

Interaction of anthracycline antibiotics with biopolymers. VIII. Binding parameters of aclacinomycin A to DNA.

The binding of aclacinomycin A to DNA was investigated spectrophotometrically under equilibrium conditions. The self-association behaviour of aclacinomycin A was identified as dimerization. Based on a model of overlapping potential binding sites the subsequent results were obtained: equilibrium constant of cooperative binding K = (7.58 +/- 2.15) X 10(6) M(-1), size of a binding site alpha = 3.98 +/- 0.14 base pairs, cooperativity parameter sigma = 0.12 +/- 0.10. These parameters were compared with those of adriamycin, daunomycin, and iremycin to draw some conclusions regarding the structural specialities of aclacinomycin A.

Aclarubicin↗
PubMed1983

Mechanical capacity of esophagogastric anastomosis at early postoperative stage.

The tensile strength of esophagogastric anastomosis was measured in 20 dogs. In case of 32 other animals the preparations were histologically examined, too. Mechanical tolerance was found significant from the 7th postoperative day on, reaching its maximum on the 15th day with no later change. An explanation is sought in the prevalence of the elastic elements growing in direct proportion to the time elapsing after operation. This role of the elastic fibres has not yet been reported in the available literature.

Animals↗
PubMed1983

[Relationship of immunological status to infections complicating surgery of the large intestine].

The patients immuno-activity has a well-known importance for the outcome of postoperative complications. The authors evaluated the immuno-activity of 95 patients before selective, radical colorectal surgery: 1) 40% of the patients were anergic compared to healthy controls. 2) The incidence of wound infections was significantly higher in the anergic groups than in normal or hyperergic ones. 3) 25% and 50% decrease in wound sepsis has been observed in anergic and normal or hyperergic groups respectively after vaccination 7 to 10 days before operation with vaccine made of E. coli, Proteus, Klebsiella and Pseudomonas strains. The difference indicates the lowered immuno-reactivity on anergic patients.

Colectomy↗
PubMed1982

Ischemic stricture of the intrathoracic roux loop used for esophagoplasty.

Three cases of stenosis of a Roux loop are presented, following the replacement of the lower third of the esophagus resected for cancer. In each case fibrotic stenosis developed 6 weeks after reconstruction, which was attributed to ischemia: in one case it was due to reduced blood flow during digitalization and in the other two cases to the vascular compression of the supplying vessels because of unsatisfactory dilatation of the hiatus.

Adult↗
PubMed1981

Cellular immune functions after heart operations.

Eight patients were observed by mitogen stimulation and E-rosetting after heart operations with and without cardiopulmonary bypass. The first sample of blood was taken before surgery, the second on the afternoon of the same day and for a week daily examinations were carried out. A depression of mitogen-stimulated lymphocyte transformation was observed, parallel with a simultaneous T cell depression and a general decrease in the total WBC count. The lowest values were found during the first three days after both open and closed heart operations. After open heart surgery it took a longer time until the values had returned to normal. In two other cases the lymphocytes were examined for suppressor activity. The suppressive effect exerted on the response to mitogenic and allogeneic stimulation was not uniform. Suppressor activity was more affected by surgery than the helper effect in these two cases.

Cardiac Surgical Procedures↗
PubMed1981

[Premalignant and malignant changes in the epithelium in an antethoracic skin tube after esophagus replacement surgery].

Seven clinical cases are described of plastic repair of the stenosed oesophagus by means of a skin tube in which premalignant changes have developed after the lapse of several decades. The authors assume that these changes have been caused by chronic inflammation due to chemical irritation of the skin tube by stagnant food, saliva, and the gastro-"neo-oesophageal" reflux. On the basis of data from the literature and personal experience, the authors suggest that use of a skin tube in the repair of the oesophagus should be reserved for the small group of patients with oesophageal malignancy not amenable to other methods of reconstruction.

Adult↗