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Biomedical subjects

I Penn

Publications and source records attributed to I Penn.

At least 127 records · Page 7Linked to original sources
PubMed1979

Renal transplantation for Wilms tumor: report of 20 cases.

Renal transplantation as part of the treatment for Wilms tumor was done on 20 patients. In 80 per cent the neoplasms were bilateral. Transplantation is indicated in individuals whose renal function is severely impaired or absent because of the malignancy, treatment or both. Patients who received homografts less than a year after treatment of the tumors had a 47 per cent incidence of recurrence or metastases compared to a zero incidence of these problems in those whose transplants were delayed for longer periods. Survival for 2 years or more was obtained in 75 per cent of the recipients with unilateral neoplasms and in 38 per cent of the patients with bilateral tumors.

Adolescent↗
PubMed1979

Kaposi's sarcoma in organ transplant recipients: report of 20 cases.

There is an increased incidence of Kaposi's sarcoma (KS) in organ transplant recipients in whom it comprises more than 3% of all de novo neoplasms. Any such patient who develops reddish blue macules or plaques in the skin or oropharyngeal mucosa, or has apparently infected granulomas that fail to heal, should be suspected of having KS. In 45% of the patients, the internal viscera are involved. This variety has a bad prognosis. Apart from conventional treatment with surgical excision, radiotherapy or chemotherapy, cessation, reduction, or modification of immunosuppressive therapy produces gratifying results in a significant number of patients.

Age Factors↗
PubMed1979

Hyperparathyroidism following parathyroid autotransplantation.

A patient with primary hyperparathyroidism underwent cervical exploration and hemithyroidectomy. Only one normal parthyroid gland was found and was removed. Hypercalcemia persisted and subsequent arteriography localized a large mediastinal adenoma which was excised. Parathyroid autotransplantation of a small part of this tissue was performed and the patient was well for over a year. He again became markedly hypercalcemic and graft-dependent elevation of parathromone levels was demonstrated. Autograft resection resulted in normocalcemia. Nineteen months later hypercalcemia and elevated parathormone levels prompted re-exploration of the graft site and another enlarged implant was removed. This restored normocalcemia and normal parathromone levels. Parathyroid adenomatous tissue has the potential for autonomous hyperfunction, and caution must be exercised in its use in autotransplantation.

Humans↗