Biomedical subjects

I Papp

Publications and source records attributed to I Papp.

At least 37 records · Page 2Linked to original sources

PubMed1992

[Clinical pathology of gastric mucosal dysplasia].

The stomach cancer develops on dysplastic lesions of gastric mucosa. It can be found in every precancerous condition, as chronic gastritis, gastric adenoma, giant rugal hypertrophy, chronic peptic ulcer, gastric stump after partial resection, pernicious anaemia. So, this dysplastic change is not a specific lesion. Different classifications are known for grading of gastric dysplasia. Authors evaluated them compared with each other. The signs of dysplasia were studied in 306 gastric aimed biopsy specimens from 233 patients between 1979-1990. In this material severe dysplasia occurred in 20.6%. It means a frequency of 0.84% regarding all gastric endoscopies in the same period of time. The endoscopic investigation revealed a protruded lesion in 18.5% and excavated one in 45.9%. What is very important, local change could not be detected in 35.6%. Follow-up study could be performed in 49 patients in a period of 1-7 years. In this group cancer developed in five patients. By the other hand, 22 gastric carcinomas were proved amongst 233 patients. The authors' recommendation is to follow-up the patients bearing gastric dysplasia at least during 10 years after the diagnosis.

Diagnosis, Differential↗

PubMed1992

[Diagnostic possibilities of endoscopic ultrasonography in the detection of gastric cancer].

After conventional gastroscopy and biopsy the endoscopic ultrasonography (EUS) was performed in 115 patients with gastric ulcer and carcinoma. The markers of benignity and malignity were analyzed by EUS, and the criteria of benign and malign excavated lesions were described. On the base of endoscopic pictures 3 groups of gastric excavations were distinguished, and the recorded images of this excavations were reevaluated. Benign ultrasonic markers were detected in one case of excavated tumors, in 54% in group of ulcers with suspicion of malignity and in 82% in cases of benign ulcers. Authors evaluate the cause of overestimate. Ten cases of early gastric cancers are reported. Authors believe that the endosonographic examinations of the stomach are valuable in detecting and stating of gastric carcinoma.

Diagnosis, Differential↗

PubMed1992

Evidence for functional heterogeneity of rat CD4+ T cells in vivo. Differential expression of IL-2 and IL-4 mRNA in recipients of cardiac allografts.

The in vivo relevance of functional dichotomy of CD4+ Th clones was studied by analyzing the induction of mRNA encoding for Th1- (IL-2) and Th2- (IL-4) specific lymphokines in a model of accelerated (24 h) cardiac allograft (Tx) rejection in presensitized rats. The polymerase chain reaction-assisted screening of total cellular RNA from cardiac Tx of otherwise untreated sensitized recipients has revealed sequential lymphokine mRNA expression, with the peak of IL-2 mRNA (6-12 h) preceding that for IL-4 mRNA, which was maximal at the time of actual Tx loss (24 h). Both IL-2 and IL-4 transcripts could be readily detected by polymerase chain reaction analysis in the spleens during the course of accelerated rejection. Treatment of prospective cardiac Tx recipients with BWH-4, a mouse anti-rat CD4 mAb, abrogated rejection at 24 h and prolonged cardiac Tx survival to ca. 11 days, coinciding with significantly diminished IL-2 mRNA expression. In contrast, CD4 targeted therapy preserved intra-Tx and splenic transcription of the IL-4 gene. Spleen lymphocytes from mAb-conditioned recipients separated by magnetic microspheres into phenotypically distinct subpopulations, showed differential induction of IL-2 and IL-4 mRNA. Thus, IL-2 mRNA was at most very weakly expressed, whereas IL-4 transcription was strongly induced both in CD4+ T cells and its OX-22- subset. This study demonstrates the induction of IL-4 mRNA in situ in the rat system, describes discordant elaboration of IL-2 and IL-4 mRNA in untreated/anti-CD4 mAb-treated cardiac Tx recipients, and identifies OX-22- CD4+ T cells as the IL-4 mRNA producers. Thus, these results provide evidence for functional heterogeneity of rat CD4+ T cells in vivo, as defined by divergent mRNA lymphokine transcription profiles.

Animals↗

PubMed1990

[Esophageal and gastric candidiasis].

The authors examined the morbidity rate of mycotic diseases of stomach and esophagus. There were 746 biopsian and abrasian cytologic samplings carried out in a year and 12.3% of the cases turned out to be positive. Comparing the two sampling patterns the abrasian cytology has proved to be more effective. The prevalence of candidiasis was found to be higher in case of malignant diseases. In states accompanied by low acid values (as in case of patients under H2-receptor blocking--treatment) mycotic infection proved to be more frequent, too.

Candidiasis↗

PubMed1990

Early detection of colorectal cancer. Preliminary report on the prospective value of a combined screening method for occult rectal bleeding.

The authors have developed a specific, sensitive, simple and economic method for the detection of occult colorectal bleeding. The new technique consists of the traditional guaiac type reaction and an immunochemical test which as a second-phase test using dried filter paper discs serves to eliminate or reduce the false-positive reactions, decreasing the necessity of further invasive diagnostic measures. They report on their experience obtained with the screening of a rural population of 3,346 persons; a positive colour reaction was observed in 546 individuals (16.3%) who were not on diet. In the second-phase immunochemical examination, however, this number decreased to 54 (1.6%). In this group of patients, who did have blood in their stools, 5 colorectal carcinomas (9.25%), each in the early Duke stage A, could be detected. The overall detection rate of carcinoma, polyp and colitis ulcerosa, likewise a precancerous state, was 40.73%. The results obtained so far suggest that this combined screening method represents an easier, cheaper and a more rapid diagnostic method for the detection of early colorectal carcinomas and precancerous states compared to the conventional ones. In mass screening the treatment and transportation of the test specimens are simple and hygienic.

Aged↗

PubMed1988