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Biomedical subjects

I P Solov'eva

Publications and source records attributed to I P Solov'eva.

At least 19 recordsLinked to original sources
PubMed2006

[Immunophenotyping of epithelioid-cell granulomas in sarcoidosis].

The specimens of biopsy of the lung and lymph nodes from 24 patients with sarcoidosis were immunophenotyped. The monoclonal antibody panel for immunophenotyping the monocyte-macrophage cells included HLA-DR, CD64, CD163; CD7, CD3, CD4, CD8, HLA-DR, and CD20 were used to assess lymphocytic populations. In sarcoidosis, the majority of cell elements of a granuloma are in a state of activation, as evidenced by HLA-DR expression on the epithelioid, giant cells, T lymphocytes (which was observed in more than in 90% of cases), the extent of this expression decreasing as fibrosis develops. There is a statistically significant correlation between the presence of individual lymphocytic subpopulations and monocyte-macrophage cells in the granuloma. No clear relationship of the phenotype of a granuloma to the clinical form (stage) of sarcoidosis suggests that is based on the common self-sustaining process of formation, functioning, and involution of granulomas, which has no direct agreements in the X-ray and laboratory manifestations of the disease.

Adult↗
PubMed2004

[Viral inclusions of sarcoid granuloma into the epitheliocytes].

Electron microscopy was used study the cellular composition of sarcoid granulomas in the lung of 10 patients. In 4 patients, epithelioid cells contained herpes virus virions. In these patients, the disease clinically began acutely, ran along with erythema nodosum; their treatment involved glucocorticosteroids. In the other patients, the cells of sarcoid granulomas did not contain viruses, the granulomas were at the fibrosing stage; diffuse pneumosclerosis was clinically diagnosed. It is suggested that in sarcoidosis, immunity is of not sterile character and the phagocytosis of virus aggregates with epithelioid cells demonstrates the degree of endocytobiosis. This process takes place in tuberculosis, which is a manifestation of the biological expediency of endocytobiosis as this allows infection immunity to be maintained.

Epithelial Cells↗
PubMed2001

[Videothoracoscopy in diagnosing and treating exudative pleuritis].

Telethoracoscopy (TT) was performed in 76 patients with exudative pleurisy of unclear etiology. A correct diagnosis was made in all (100%) cases. Tuberculosis was detected in 41 (54%) patients. In this group of patients, the results were analyzed by taking into account the duration of disease, the nature of an operation, and morphological findings. In tuberculous pleurisy, TT may be conducted at any time; however, it is most effective when an acute period subsides and an exudate begins forming. At this time (2-3 months after the onset of the disease), surgery is not diagnostic, but also remedial as sanitation of the pleural cavity with partial pleurectomy.

Adolescent↗
PubMed1993

[Changes in human pulmonary receptors in tuberculosis, chronic pneumonia and cancer].

The authors studied changes in beta- and alpha 1-adrenoceptors (beta-AC, alpha 1-AC) as well as in m-cholinoceptors in tuberculosis, pneumonia and cancer. Specimens of the lung parenchyma were obtained at thoracic surgery from 43 patients. Relevant ligands binding to the receptors was evaluated by incubation of the membrane proteins with radioligands varying in concentrations. Irrespective of the inflammation variant, beta-AC and alpha 1-AC levels were found decreased this being an correlation with the scope of fibrous and destructive involvement. The degree of the process chronicity and advance was judged from a decline in the binding parameters for beta-AC and alpha 1 AC. A dramatic fall in alpha 1 AC occurred in tuberculosis. This may be related to microcirculatory failure and vascular deformity. The levels of m-cholinoceptors underwent insignificant changes in pulmonary inflammation, whereas lung cancer displayed their sharp rise.

Adenocarcinoma↗
PubMed1989

[Treatment of nonspecific endobronchitis with low-intensity laser irradiation (experimental study)].

Results of endobronchial treatment of experimental purulent endobronchitis (PE) in dogs with low intensity He-Ne laser are presented. The endobronchial use of the laser energy in treatment of PE was shown expedient and valid. Comparison of the visual endoscopic picture with the findings of the histochemical and electron microscopic examination of the bronchial mucosa bioptates in the time course of the treatment provided establishment of the optimal regimen for the treatment of nonspecific PE with He-Ne laser.

Animals↗
PubMed1989

[State of the endometrium in patients with female genital tuberculosis according to biopsy data].

Comparison of the clinicoanatomic materials relating to 430 female patients with genital tuberculosis showed that 56 per cent of the patients had hormonal disorders among which deficiency of the cycle phase II or anovulation predominated. Variants of glandular cystic hyperplasia were the most frequent morphological equivalents of the hormonal disorders. In the morphological characteristics of the glandular cystic hyperplasia variants there were no differences in the level of gland and stroma maturity in the groups under observation. The use of the method of informative entropy in estimation of endometrium pathology provided objective morphological diagnosis and extended the diagnostic possibilities due to detecting hormonal disorders at the subclinical level which was especially important for early correction of the hormonal disorders.

Adult↗
PubMed1987

[Clinico-anatomic correlations in active forms of tuberculosis].

Basing on 1957 autopsies of the patients with active forms of TB that has been incorrectly diagnosed either intravitally, or postmortEM, the authors distinguish 5 forms of discrepancy between the pathoanatomical and clinical diagnoses. Thus, spread progressive TB was primarily diagnosed postmortem in 12.3%; the discrepancy of the diagnoses in form, stage, specific TB complications was found in 46.5%; "pseudo-diagnosis" of TB was made in 1.7%; the difference in the diagnoses concerning the associated diseases was noted in 26.6%; no information on TB in the pathoanatomical diagnosis when death occurred of other diseases and accidents was found in 12.9%. To improve the intravital and postmortal diagnosis of TB the authors recommend to organize a course of lectures on TB for different specialists, as well as to introduce special cards of emergency to be sent by the pathologic anatomists and medicolegal experts to the antituberculous dispensaries.

Diagnostic Errors↗