Biomedical subjects
Publications and source records attributed to I O Tin'kova.
Structural and metabolic changes in nephrocytes during peritonitis were studied on early autopsy material. Unspecific morphological changes in the kidneys were presented by circulatory disturbances and damage to the tubular epithelium. The changes in dehydrogenase activity in nephrocytes of the proximal and distal tubules depended on the cause of peritonitis.
Macroscopic and histological characteristics of focal nodular hyperplasia (FNH) of the liver are presented. Characteristic microscopic signs are the presence of numerous septs with many biliary ducts. Hepatocytes with diploid number of chromosomes show negative Ki-67 and p53. Ultrastructure of hepatocytes in FNH does not differ from that of normal cells of the liver.
A case of hepatobiliary liver cystadenoma in a 45-year-old female is reported. The tumour looked like a multifocal cyst 18x12x8 cm in size with yellowish content. Inner surface was represented by a column epithelium with nuclei located in the basal part of the cells. Immunohistochemically expression of cytokeratin 19 (similar to the epithelium of bile ducts) was revealed.
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A rare case of hepatoblastoma is reported in a female of 47 years of age with literature review of these tumors in the adults. Microscopically the tumor was represented by the cells of embryonal and fetal types. Immunohistochemically expression of low-molecular cytokeratins as well as that of S-100 protein and hepatocyte antigen was observed.
The authors describe one case of squamouscell carcinoma of the liver, which developed in a 54-year-old male. The gross tumor was a cyst, 10 cm in diameter, with the brown contents. A histological study revealed high-grade differentiated squamous-cell carcinoma without keratinization. An immunohistochemical study showed a positive reaction with cytokeratin 19 and PCNA expression in single nuclei of tumor cells.