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Biomedical subjects

I Narama

Publications and source records attributed to I Narama.

82 records · Page 5Linked to original sources
PubMed1983

The morphogenesis of a papillomatous gastric polyp in the crab-eating monkey (Macaca fascicularis).

The histopathology of gastric papillomas in 17 crab-eating monkeys from Indonesia and Malaysia was investigated. The changes in the affected mucosa consisted of papillomatous proliferation with accidental heterotopia, desquamation or necrosis of the epithelium associated with eggs or adults of the small nematode Nochtia nochti, inflammatory cell infiltration and haemorrhage or oedema and fibrosis. The primary pathogenic effect of this parasite was due to its irritant action on the gastric mucosa. Hyper-regeneration, with a downward shift of the proliferating zone in the gastric gland and an inflammatory process, appeared to play a significant role in the morphogenesis of this lesion. It is concluded that the gastric papilloma associated with Nochtia nochti in the monkey is a parasitic inflammatory polyp.

Animals↗
PubMed1983

Naturally occurring Tyzzer's disease in a clean mouse colony: high mortality with coincidental cardiac lesions.

Light and electron microscopic examinations were performed on tissues from 12 young mice which were affected by naturally-occurring Tyzzer's disease. Eight of the 12 mice had cardiac lesions which have not previously been reported in mice and which caused a high mortality. The cardiac lesions were detected in mice which had severe and advanced intestinal lesions which penetrated the deeper mucosa and muscular layer with active regeneration of the mucosal epithelium. Periodical serological tests to monitor the bacterial and viral status of this colony showed that it was free of other agents of murine disease such as mouse hepatitis virus, Corynebacterium kutscheri and Salmonella spp. until the onset of Tyzzer's disease and that no mixed infection occurred at the onset. It is considered that an advanced intestinal lesion is essential for the formation of cardiac lesions in Tyzzer's disease in mice.

Animals↗
PubMed1980

[A simplified method for detection of visual abnormality in the rat in a reproduction study (author's transl)].

A Y-shaped test box was designed for the screening of visual abnormality using negative phototaxis in normal rats. Its availability was determined by examination of 100 animals belonging to non-treated, eyelids-sutured, and eyeballs-enucleated groups. Two kinds of examination were undertaken, the first being observation of the general behavior of the animals in the box for one minute. The second was 4 trials at selection of the dark area of the box given to each animal. In each examination many animals could be tested in a short time. The behavioral pattern of the eyelids-sutured and the eyeballs-enucleated groups was significantly different from that of the non-treated group. The selection rate for darkness by non-treated, eyelids-sutured and enucleated groups in the second examination was 97.5%, 84.5, and 50.0 percent, respectively. Therefore successful estimation could be possible by both procedures and it was possible to numerize the gained value and analyze statistically in the second examination. It was concluded that this simplified method for testing visual function should prove very useful as a behavioral teratology screening test in routine reproduction studies.

Animals↗
PubMedDate not supplied

Iron lactate-induced osteopenia in male Sprague-Dawley rats.

Osteopenia was induced in rats fed a diet containing 50,000 ppm (5%) iron lactate for 2 or 4 weeks. Blood chemistry, urinalysis, and bone histomorphometry of the proximal tibial metaphysis were performed. Urinary pyridinoline and deoxypyridinoline and the osteoclast number per bone surface were selected for the measurement of dynamic resorption. The osteoclast surface, eroded surface, and osteoblast surface increased at both ends of the exposure periods, and bone resorption and formation both increased. The bone volume, trabecular thickness, and trabecular number decreased, and the secondary spongiosa of proximal metaphysis showed a marked bone loss. However, no mineralization defect was observed. At the end of the 2-week exposure period, biomarkers of osteoclasts and osteoblasts had increased the most, and the osteoblast surface, osteoclast surface, and osteoclast number per bone surface increased with prolonged exposure. The pathological changes of the bone lesion in iron lactate-overloaded rats were similar to those in rats of the osteoporotic model, because they consisted of changes reflecting the increase of bone resorption and formation without an osteomalacic change. However, the decline of serum parathyroid hormone (PTH) levels was different from that of the osteoporosis model rat. We concluded iron-induced bone lesions probably differ from those of low turnover bone diseases.

Administration, Oral↗
PubMedDate not supplied

Malignant theca cell tumor of rat.

A large-sized ovarian tumor of theca cell origin was found in a female rat. The mass was located in the right ovary position. Histologically, the tumor was covered by thin fibrous capsule and consisted of a solid area and an abundant necrotic area. Tumor cells were arranged in a storiform or whorled pattern. Connective tissue elements occasionally presented as bundles of dense collagen fibers. Fusiform to elongated cells had oval- to spindle-shaped nuclei with indistinct nucleoli. Large round nuclei and mitotic figures were scattered throughout the tumor cells. These cells were stained positively with S-100 but negatively with vimentin and a-smooth muscle actin. Tumor cells with abundant cytoplasm sometimes contained multiple small-sized lipid vacuoles.

Animals↗
PubMedDate not supplied

Eosinophilic gastroenterocolitis in iron lactate-overloaded rats.

Eosinophilic gastroenterocolitis with peripheral eosinophilia was induced in rats fed a diet containing 2.5% or 5.0% iron lactate for 3 mo. Additional findings consistent with iron overload were also observed. Microscopically, the lesions consisted of eosinophilic infiltrations in the mucosa and submucosa along the whole length of the gastrointestinal tracts, increased surface area of the gastric mucosal propria covered with mucous cells, and increased apoptotic bodies in the gastric glandular neck of rats in the 2.5% and 5.0% groups. An increased number of intraepithelial globule leukocytes in the gastric and intestinal lamina propria was also observed in the 5.0% group. Globule leukocytes in the gastric mucosa contained obviously enlarged granules in their cytoplasm in these rats. The granules of the globule leukocytes were positive for rat mast cell protease II, suggesting the mastocyte origin of these cells. Although severe infiltration of eosinophils and globule leukocytes suggested a type-1 hypersensitivity reaction, other features such as an increasing vascular permeability were not detected. Serum IgE levels in the 5.0% and control groups were < 3 ng/ml. Final body weights of male and female rats of the 5.0% group were suppressed to 70% and 90%, respectively, of those of the control rats, whereas food consumption was comparable to that of the control group. The morphologic characteristics of the gastrointestinal lesions and peripheral eosinophilia induced in rats fed iron lactate were very similar to those in some cases of eosinophilic gastroenterocolitis in humans and other animals.

Animals↗