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Biomedical subjects

I Nakamura

Publications and source records attributed to I Nakamura.

At least 361 records · Page 20Linked to original sources

[Seasonal variation of menarche and month of birth (author's transl)].

Seasonal variations in the occurrence of menarche in 1226 Japanese girls are not uniform, when they were divided into two groups by their season of births. Summer trough (May-July) was inapparent in girls born in summer (May-October), and winter trough (February-March) was less deep in girls born in winter (November-April). No differences were found in fall trough (September-November) between both groups. Girls born in summer (or winter) seem to be resistant to some summer (or winter) factors, which inhibit the occurence of menarche.

Adolescent↗

Mercury content in museum and recent specimens of chiroptera in Japan.

The mercury content of insectivorous Chiroptera caught in 1890, when mercurial pesticides had not yet been in use, and preserved in a museum in alcohol were compared with those caught in 1965--1967 or 1970--1975, during and after the use of mercurial pesticides, and kept frozen. The mercury content of the Chiroptera caught in 1890 was lower than that of those caught during or after the use of mercurial pesticides. Difference in mercury content between bats caught during and after use was not significant.

Animals↗

Effects of thiamine and pyridoxine on the lipid composition of Saccharomyces carlsbergensis 4228.

The lipid composition of Saccharomyces carlsbergensis 4228 cells grown aerobically in the presence of thiamine and absence of pyridoxine was markedly different from that of cells grown without addition of both of the growth factors. In addition to the previous observations showing a reduction in the levels of unsaturated fatty acids (Nishikawa, Y., Nakamura, I., Kamihara, T. and Fukui, S. (1974) Biochem. Biophys. Res. Commun. 59, 777-780) and lack of zymosterol and ergosterol (Nagai, J., Katsuki, H., Nishikawa, Y., Nakamura, I., Kamihara, T. and Fukui, S. (1974) Biochem. Biophys. Res. Commun. 60, 555-560), the thiamine-grown cells were found to contain low levels of total lipids, sterols (especially in the form of esters), triacylglycerols and total phospholipids. However, relative contents of triacylglycerols and phospholipids to total lipids were higher than those of control cells. Hydrocarbons and diacylglycerols accumulated to appreciable degrees. Phospholipid composition was also influenced by thiamine. The ratio of phosphatidylinositol to total phospholipids increased, whereas that of phosphatidylethanolamine decreased. The levels of phosphatidylcholine plus phosphatidylserine decreased in a similar ratio to that of total phospholipids. It was found that unsaturated fatty acid contents were low in all lipid esters tested. The effect of thiamine was particularly noteworthy in the case of sterol esters. Concomitant addition of pyridoxine with thiamine to the medium brought about a normal lipid composition in the yeast cells.

Diglycerides↗

Reduced mercury excretion with feces in germfree mice after oral administration of methyl mercury chloride.

When methyl mercury chloride was administered orally the amount of mercury excretion with feces of germfree mice was noticeably lower than that of the control mice. Germfree mice excreted 24 percent of the administered mercury within 10 days of administration while the control mice excreted 46 percent. Mercury retention in the organs of germfree mice was slightly higher than in the control mice. These results suggest that the existence of microorganisms in animal intestines are concerned with mercury excretion in the animal body.

Animals↗

Change in radiosensitivity of sea-urchin eggs during early cleavage stages. III. Effects of split-dose irradiation with 137Cs gamma-rays.

When sea-urchin eggs were irradiated with 137Cs gamma-rays, their radiosensitivity, expressed by the percentage which formed pluteus larvae, fluctuated during the early cleavage cycle. Split-dose irradiations were made both in the sensitive and resistant phases. For eggs in the sensitive phase, the effect of the first exposure of 500 rad was not diminished during the interval before the second exposure. Eggs irradiated in the resistant phase were only slightly damaged. Results imply that fluctuations in radiosensitivity of sea-urchin eggs are caused mainly by different degrees of non-repairable damage in each phase of cleavage rather than by different recovery abilities.

Animals↗

An unusual case which began with subcutaneous panniculitis followed by fever, severe hepatic involvement and hyperlipidemia.

A 25-year-old man was at first dermatologically suspected as suffering from Weber-Christian syndrome because of subcutaneous panniculitis, but his skin lesions disappeared completely during the course. Hyperlipidemia, disturbances in liver function, and leukemoid reaction became remarkable and he died of subarachnoid hemorrhage eleven months after onset. Necropsy revealed subarachnoid hemorrhage at the base of the brain, lipogranulomatous and inflammatory lesions in the upper lobe of the left lung, a remarkable fatty liver, splenomegaly, pericarditis, and foam cells in the spleen, liver, and bone marrow. A comparison with 57 autopsy cases of Weber-Christian syndrome reported in the literature showed our case to be an exceptional instance of Weber-Christian syndrome, if the present case is not to be regarded as a different disease entity.

Adipose Tissue↗

Season of birth of schizophrenics in Tokyo, Japan.

The monthly distribution of births of 7,960 schizophrenic patients in Tokyo born during the period of 1841-1950 was studied in comparison with that of a control population in Tokyo. A spring excess of schizophrenic births were found after 1901 as in previous studies in Western countries. Before 1900, however, there was no significant spring excess. The maximum excess of schizophrenic births occurred in May before 1900 and in April after 1901. The possibility of a shift in the seasonality of schizophrenic births was discussed.

Birth Rate↗