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Biomedical subjects

I Nakajima

Publications and source records attributed to I Nakajima.

At least 163 records · Page 9Linked to original sources
PubMed1988

Long term liver preservation using artificial blood substitutes.

Twenty-four hour hypothermic perfusion preservation of the liver was aimed using an artificial blood substitutes. A canine liver was harvested and preserved using originally designed perfusates. In group 1, Perfluorotributylamine solution (Oxypherol solution) was used. In group 2, (Pyridoxylated hemoglobin)-(Polyoxyethylene) conjugate solution (Stabilized Hemoglobin, PHP-1). In group 3 and in group 4, modified Stabilized hemoglobin, PHP-3 and PHP-4 was used. After the preservation, each liver was transplanted orthotopically. Postoperative graft function was estimated the following parameter, such as bile excretion, consciousness level, activated clotting time, and survival rate. In group 1 and group 2, improvement of such factors were not fully observed. On the contrary, in group 3 and 4, complete recovery of the function was seen and in group 4, longer survival was obtained. PHP solution was considered suitable perfusate for liver preservation.

Animals↗
PubMed1988

[A case of gastric carcinoma remarkably responding to etoposide, adriamycin and cisplatin (EAP) therapy].

A 47-year-old male was diagnosed as having gastric cancer with metastases to liver, para-aorta node and Virchow node. He was treated with EAP (Etoposide, Adriamycin, Cisplatin) therapy, as a result of which a partial response was obtained according to the criteria of the Jpn. Soc. Cancer. Ther. The response was disappearance of subjective symptoms and Virchow's metastasis and reduction of chief tumor and liver metastases. However, this therapy was accompanied by severe side effects such as leucopenia and thrombocytopenia, but in this case, these side effects improved within 20 days.

Adenocarcinoma↗
PubMed1986

The effect of load alteration on the biological and biomechanical performance of a titanium fiber-metal segmental prosthesis.

The effect of overloading and underloading on tissue ingrowth into the porous-coated titanium segmental prosthesis was studied in a canine femoral model. The prosthesis has modular components that are connected by a conical coupling joint. One of the dog's hind legs was immobilized and suspended for three weeks using an external fixator to minimize loading and prevent weight-bearing, while the contralateral leg was allowed to bear weight freely, simulating an overloading situation. Five dogs reached the final study period of twelve weeks without complication. There were no significant differences between the non-weight-bearing and weight-bearing sides on radiographic assessments. However, the immobilized side had significantly higher stem-push-out strength and energy to failure. Bone ingrowth was variable, and a fibrous layer was commonly demonstrated at the prosthetic stem-bone interface. The orientation of the fibrous tissue was more organized, in a penetrating pattern, on the immobilized side. The mean concentration of titanium was insignificant in all tissue examined. Reduced implant loading for the porous-coated segmental bone prosthesis during the initial period of implantation was found to be beneficial as compared with an overloading situation in achieving intramedullary fixation.

Animals↗