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Biomedical subjects

I Nagata

Publications and source records attributed to I Nagata.

At least 289 records · Page 16Linked to original sources
PubMed1986

[Visual disturbances in moyamoya disease].

Visual disturbances in moyamoya disease are evaluated. Forty-three among our series of 178 cases of moyamoya disease were suffered from various visual symptoms such as visual field defect, attack of blindness, decreased visual acuity, scintillating scotoma. These visual manifestations were resulted from the occlusive lesions in the posterior circulation. In comparison with the cases of adult onset, those of juvenile onset tend to develop visual disturbances. STA-MCA anastomosis with EMS exerts indirect redistribution effect upon the posterior circulation in moyamoya disease. In most cases, improvement in the visual disturbances followed these bypass operations. However, in five cases, omentum transplantation to the occipital lobe as the method of direct revascularization were needed.

Adolescent↗
PubMed1986

A case of adiposis dolorosa: lipid metabolism and hormone secretion.

The present report describes a 53-year-old non-obese man with adiposis dolorosa whose pain was dramatically relieved by the intravenous injection of lidocaine. The patient showed a paradoxical response of growth hormone to thyrotropin-releasing hormone. In addition, in-vitro studies on adipose tissue metabolism revealed the reduced glucose conversion to neutral glycerides in painful adipose tissue. These abnormalities may be related in some ways to the pathogenesis of this disorder.

Adipose Tissue↗
PubMed1985

Regional differences in carboxylesterase activity between human subcutaneous and omental adipose tissue.

Human adipose tissue was shown to contain carboxylesterase activity when measured by methylbutyrate as substrate. The enzyme has the same characteristics as carboxylesterase purified from rat epididymal adipose tissue. Like lipoprotein lipase, carboxylesterase activity was higher in large than in small fat cells. Both cell size and carboxylesterase activity were greater in human subcutaneous than in omental adipose tissue. However, the linear regression lines between the enzyme activity and cell volume in the two tissues were almost superimposable, suggesting that cell size is a determinant of enzyme activity. Although the physiological significance of adipose tissue carboxylesterase must await further clarification, it is possible that the enzyme is related to the hydrolysis of long-chain monoacylglycerols.

Adipose Tissue↗
PubMed1985

1,25-Dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 suppress in vitro antibody response to T cell-dependent antigen.

1,25-Dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 suppressed an antibody response to sheep red blood cells (SRBC, T cell-dependent antigen) by murine splenocytes, in concentrations ranging from 10(-10)-10(-7)M. These suppressive effects were markedly abrogated when T cell-depleted lymphocytes were cultured in the presence of a supernatant of concanavalin A-stimulated spleen cells. On the contrary, neither of them suppressed antibody response to trinitrophenyl-lipopolysaccharide (T cell-independent antigen). These results suggest that the suppressive effect of active vitamin D3 on anti-SRBC response was mediated by the inhibition of T cells.

Animals↗
PubMed1985

Abdominal repair of vaginal prolapse and the postoperative outcome as judged by a scoring system and X-ray colpography.

Three abdominal procedures were combined to suspend the prolapsed vagina in patients with post-hysterectomy vault prolapse and a narrow vagina and uterine prolapse with pelvic diseases (such as fibroids) necessitating laparotomy. We used Moschcowitz's method (obliteration of the cul-de-sac by purse-string sutures) Burch's method (fixation of the anterior vaginal wall to Cooper's ligament) and Williams and Richardson's method (suspension of the vaginal stump using fascial strips from the external oblique aponeurosis. The postoperative outcome of 8 operations was judged by a scoring system and by X-ray colpography with superimposition of films obtained at rest and during straining (subtraction technic). The scoring system indicated that the anterior vaginal wall and the vaginal vault were well supported by this combination procedures. However, the prolapse of the lower posterior vaginal wall needed an additional vaginal repair. The X-ray colpogram showed that the axis of the repaired vagina was slightly more vertical than normal. But displacement of the vagina on straining was within the normal range. Neither dyspareunia nor stress urinary incontinence were seen as complications of our procedures.

Adult↗
PubMed1985

Increased cyclic nucleotide phosphodiesterase (PDE) and calmodulin activities in soluble fraction of Graves' thyroid: analysis of increase in Ca+2 dependence of PDE activities.

Phosphodiesterase (PDE) and calmodulin (CaM) activities were studied in soluble fractions of normal and Graves' thyroid tissue. Normal and Graves' thyroid tissues were obtained at thyroid surgery. PDE activities were assayed with cAMP and cGMP as substrates. CaM activity was measured as the ability to activate bovine thyroid CaM-dependent PDE. cAMP and cGMP PDE activities were increased 1.5- and 2.2-fold above normal in Graves' thyroid, respectively. The major cause of the increase in enzyme activities was their higher Ca+2 dependence. CaM activity also was 1.6-fold increased in Graves' thyroid, although it probably does not contribute to the increase in the Ca+2 dependence of PDE activities because of its relative sufficiency vs. PDE in normal thyroid. Three forms of cAMP and cGMP PDE activities were eluted from Sephadex G-200 columns, with mol wt of 280,000, 140,000, and 80,000-100,000, respectively. The first peak had little or no CaM dependence, the second peak had moderate or dominant CaM dependence, and the third peak revealed weak or dominant CaM dependence. The increase in the CaM-dependent form of the third peak of PDE activity in Graves' thyroid tissue may explain the increase in Ca+2 dependence of PDE activities.

2',3'-Cyclic-Nucleotide Phosphodiesterases↗
PubMed1985

A novel lymphokine derived from human IgG Fc receptor-bearing B cells: its suppressive effect on activated T and B lymphocytes including tumour cells in vitro.

Peripheral blood FcR gamma-bearing human B cells, but neither T cells nor adherent cells, produce an immunoregulatory lymphokine after receiving the stimulation of FcR gamma by immune complexes--antibody-sensitized erythrocytes (EA). This factor suppresses polyclonal immunoglobulin (Ig) production of B cells to pokeweed mitogen (PWM) and Nocardia opaca delipidated cell mitogen (NDCM), indicating that not only B cells, but also T cells are targets for this factor. It also inhibits the proliferation of mitogen-activated mononuclear and T and B tumour cells in vitro. The inhibitory effect on tumour cell growth is cytostatic, but not cytotoxic as in the case of lymphotoxin (LT). All these suppressive effects are observed in a HLA-non-restricted manner. Irradiation (2000 rads) of FcR gamma + B cells does not inhibit the production of this suppressive factor, implying that DNA synthesis is unnecessary. Nonstimulated FcR gamma + B cells retain the precursor activity for Ig-forming cells, since mononuclear cells untreated with EA respond to the mitogens, resulting in Ig production. However, it is worthy to note that they lose the activity when stimulated with immune complexes. Thus, the property obtained from human FcR gamma + B cells is similar to, but distinct from, a murine suppressive B-cell factor (SBF) prepared by the same procedure as for the human factor. Nevertheless, the observation in the present studies on the human analogue to murine SBF suggests that this factor, tentatively termed human SBF, appears to be a novel lymphokine which is different from any other factors, including LT, and that FcR-bearing B cells play an important role in the immunoregulatory mechanism in humans, as in the case of mice.

Antibody-Producing Cells↗
PubMed1985

[Study of adult cases of moyamoya disease].

Fifty-one adult patients with moyamoya disease were studied. Among these, thirteen cases, which had the history of cerebral ischemic attack during childhood, are classified as the cases of juvenile onset. The other thirty-eight cases were classified as those of adult onset. In most of the cases of juvenile onset, occlusive lesions also affected cortical arteries. For these cases, it is important to perform STA-MCA double anastomoses and encephalo-myo-synangiosis. Those of adult onset resembled the pathophysiology of internal carotid artery occlusion, or that of middle cerebral artery occlusion, since few cortical artery occlusion was noted, and leptomeningeal anastomosis was well developed. STA-MCA anastomosis was considered to be the treatment of choice in those of adult onset.

Adolescent↗
PubMed1984

Moyamoya disease associated with bilateral occlusion of the vertebral artery.

An unusual case of moyamoya disease associated with bilateral occlusion of the vertebral artery is reported. This case shows several embryologic collateral channels, which are typical of moyamoya disease, around the brainstem, that is, a transdural anastomosis between the superior cerebellar artery and the posterior meningeal artery, a leptomeningeal anastomosis between the superior cerebellar artery and the posterior inferior cerebellar artery, and moyamoyalike collateral vessels via primitive lateral anastomotic channels of Padget . Bilateral encephalomyosynangiosis (temporal muscle graft) were performed. Postoperatively, no ischemic attacks have developed for 6 years.

Adolescent↗
PubMed1984

Study of the posterior circulation in moyamoya disease. Clinical and neuroradiological evaluation.

Eighty-two cases of cerebrovascular moyamoya disease were studied by cerebral angiography and computerized tomography. Occlusive lesions were demonstrated not only in the anterior circulation but also in the posterior circulation, and they were associated with the development of an abnormal vascular network (moyamoya vessels). Although occlusive lesions do occur in the vertebrobasilar system, the vertebrobasilar system also acts as a source of collateral channels to the anterior circulation in this disease.

Arterial Occlusive Diseases↗