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Biomedical subjects

I N Sokolova

Publications and source records attributed to I N Sokolova.

At least 19 recordsLinked to original sources
PubMed2000

[Extended gastropancreatoduodenal resection (GPDR)].

The authors for the first time in Russia have begun serial performance of the extended GPDR. The operations were accompanied by careful morphological investigations of the removed organs and tissues. It was established that in all patients with exocrine cancer of head of the pancreas the tumor growth extended the region of the regional lymph nodes, i.e. standard GPDR in these patients oncologically could not be considered as adequate operation. Further performance of GPDR for pancreatic head exocrine cancer will expand knowledge about metastatic spread and will open opportunities to improve long-term survival of the patients with exocrine cancer of the head of the pancreas.

Adenocarcinoma↗
PubMed1999

[Sarcoma arising from Langerhans cellsĭ].

A rare case of tumor arising from Langerhans cells in the tongue and neck area in a 37 year-old man is presented. It was a polymorphocellular sarcoma with bean-like twisted nuclei. Electron microscopy identified granules of Langerhans (Bierbeck), multiple tubulo-vesicular structures, ring-like plates, Golgi apparatus, lysosomes and dendritic processes. Total leukocytic antigen was assayed in tumor cells but no expression of S-100 protein found.

Adult↗
PubMed1996

[Experience in treating Nephroblastomas].

The treatment of nephroblastomas which accounts for 72% of all malignant neoplasms in children is one of the topical problems of pediatric oncology. To detect the tumor at early stages of a tumorous process is one of the main conditions of successful treatment for nephroblastomas. The histological types of nephroblastoma, its international classifications and present-day treatment policy are given. A role of radiation treatment is shown at pre- and postoperative therapeutical stages. Drugs, their combinations, and the efficiency of polychemotherapy regimens in use are outlined. The importance of comprehensive examination of the patient to determine the extent of malignancy and to choose adequate antitumor treatment regimens is emphasized.

Child, Preschool↗
PubMed1989

[Ultrastructural manifestations of the functional plasticity of the renal glomerular endothelium in vertebrates].

Studied has been the fine structure of the kidney's glomerulus endotheliocyte of man (age 2-6 years) and fish (year-old Atlantic salmon Salmo salar L.), as organisms occupying extreme place in development of kidney in phylogenetic line of the vertebrates. Revealed has been the uniformity of geometric reconstruction of vascular endothelium of kidney's glomerulus of investigated objects under heterogeneous factors' influence (compensatory hyperfunction of man and environment influence of fish). Formation of star-shaped structures with large open fenestrae in its central part (diameter 100-150 nm) both in the local parts of endothelium and in space between them (diameter 250-350 nm) has been observed. Such construction peculiarity sharply increases permeability of capillaries of kidney's glomerulus and thus appears as a characteristic sign of strenuous functional activity of the filtration apparatus of metanephros of man and mesonephros of fish. Revealed reaction of endothelium is considered as universal and nonspecific.

Animals↗
PubMed1989

[Electron microscopic study of the cytoskeleton of human podocytes].

The ultrastructural study of man's cytoskeleton of podocytes is carried out. Populations of podocytes with two different types of structure of the cytoskeleton in dependence on age (2, 4, 6, 37 and 65 years) is revealed in kidneys. The first type of cytoskeleton of the podocyte is peculiar for children's age and is characterized by branched, high density microfilament network, expressed by system of microtubules and single myofilaments. The intermediate filaments here are either utterly absent or present so feebly they find themselves "disguised" by other strongly developed components of cytoskeleton and revealing them with the help of technique of electron microscope is impossible. In kidneys of adults, and especially of old aged persons podocytes with other type of organization of the cytoskeleton are mainly identified. The distinctive signs of the last are bundle arrangement of microfilaments, plural bundles of intermediate filaments and individual microtubules. This study permits to make a conclusion that during individual development and growing old in kidneys of high animals and man, probably, physiological changes causing morphological reconstruction of cytoskeleton which is accompanied by intensive development of intermediate filaments' system with simultaneous "involution" of microtubules and microfilaments' systems take place.

Actin Cytoskeleton↗
PubMed1989

[Flow cytometry of DNA in research on kidney tumors].

The DNA content was studied in 22 patients (including 10 children) with renal tumours. Renal clear cell carcinomas were mainly diploid (5 of 6 cases); one clear cell and other variants of renal cell carcinoma were aneuploid. There was a correlation between the degree of tumour cell anaplasia and ploidy of renal cell carcinomas: all diploid carcinomas were of I and II degree of anaplasia, aneuploid carcinomas, except one case, were of degree III of anaplasia. 5 out of 9 nephroblastomas were diploid, 4, aneuploid. The distinctive features of nephroblastoma were pronounced proliferative activity of tumour cells and a low DNA index of the aneuploid cell line which in all cases was localized in the vicinity of the diploid region. The remaining tumours (papillary epithelial nephroma, juxtaglomerular cell tumour and malignant schwannoma) were diploid with a relatively low proliferative activity of tumour cells.

Adult↗
PubMed1989

[A case of Wilms' tumor and neuroblastoma of the kidneys in a child].

Both kidneys in an 8-month-old boy contained tumours; Wilms' tumour was found in the right kidney and neuroblastoma in the left one. Nephroblastomatosis was observed in both kidneys. Multiple skin angiomas were observed after birth. Diagnosis of renal tumours was confirmed electron microscopically.

Humans↗
PubMed1988

[Nephroblastoma with intestinal differentiation].

Available are two cases of Wilms's tumor with focal intestinal differentiation. Goblet- and endocrine-like cells as well as those similar to enterocytes were identified in one of the tumors upon electron microscopy. Squamous epithelial, cartilaginous cells, rabdomyoblasts presented in both cases. Problems of histogenesis and prognosis are under discussion.

Child, Preschool↗
PubMed1988

[Malignant epithelioid schwannoma of the kidney].

Malignant epithelioid renal schwannoma was recorded in a 16-year-old youth. Examined light-optically and electron-microscopically, it showed signs of multiprofile differentiation involving elements of a malignant schwannoma, neurofibroma, undifferentiated epithelioid component, photoreceptors, cells with neuroendocrine granules, Vater-Pacini corpuscles.

Adolescent↗
PubMed1987

[Mesoblastic nephroma].

Three cases of the "cellular" variant of mesoblastic nephroma are reported. A feature of one of them was prolonged (7.5 months) spontaneous development of the tumor which presented a peculiar morphologic appearance. Diagnostic differentiation of mesoblastic nephroma from Wilm's tumor and sarcomas is discussed. Results of an electron-microscopic study of one of the tumors are given.

Diagnosis, Differential↗
PubMed1987

[Papillary tumors of the kidneys in children].

Five rare papillary renal tumors (2 tubular adenomas and 3 epithelial nephromas) found in children (4 of them girls) 7 months to 4 years old, are reported. Four of the tumors occurred in the right kidney. Micro- and ultrastructural characteristics of tumors of this type are described for the first time, and their histogenesis and diagnosis are discussed.

Adenoma↗
PubMed1987

[Mixed tumors of the kidney and lung].

A renal tumor composed of fibrous and smooth-muscular tissues and containing focally disposed foam cells and tubular structures composed of cuboidal epithelium was found in a 2-year-old girl along with a similarly structured pulmonary tumor. The tumors were thought to be of a hamartoma nature and to have probably arisen from the mesonephros.

Child, Preschool↗
PubMed1987

[Results of the electron microscopic diagnosis of human tumors (an analysis of 1000 cases)].

A review of electron-microscopic diagnostic investigations made on biopsy specimens from 1000 patients showed the range of tumors requiring ultrastructural diagnosis to be fairly broad, encompassing virtually all major tumor sources including soft tissues (37% of the cases), epithelium (31.8%), hematopoietic organs (21.3%), pigment-forming tissues (4.9%), and bones (3.3%). The tissue and cellular origin of the tumor was identified, i.e. a differential diagnosis was correctly made and/or the histogenetic (cytogenetic) type of the tumor was established, in most (83.0%) of the cases, whereas the organ of tumor origin was identified in only 6.0%. Electron-microscopically, the histological diagnosis was confirmed in 45.3% of the cases, made more precise in 19.0%, and discarded in 5.1%; in 5.8%, electron microscopy confirmed as correct one of the diagnoses presumed on histologic grounds, while in 3.9% the diagnosis could not be verified because the tumors consisted of undifferentiated cells in their entirety. Historic material (formalin-fixed or from paraffin blocks) and stained histologic sections were used for the ultrastructural diagnoses.

Biopsy↗
PubMed1986

[Melanocytic schwannoma].

One observation of melanocytic schwannoma in a woman aged 53 is described. The tumour localized in the subcutaneous fat of the crus and looked like an encapsulated node. Electron-microscopic study indicated the signs of schwannoma and the presence of premelanosomes in the tumour cells. Polymorphism of the cells and the increase in mitotic figures was suggesting of a malignant character of the tumour. The differential diagnosis with melanoma should be based on clinical, light-optical and ultrastructural data.

Female↗
PubMed1985

[Neurinoma with peritoneal dissemination].

A rare observation cellular neurinoma in a female of 62 is described, with a primary site of tumour in the mesenterium of the small bowel, recurrence of the disease 4 years after and peritoneal dissemination. In all nodes the tumour consisted of monomorphic cells forming twisting and palisade-like structures, few mitotic figures were seen. There were no signs of cell polymorphism. Electron microscopic examination revealed a cell structure characteristic of neurinoma' multiple complex cell processes containing single organelles, accumulations of microfilaments, collagen with a high periodicity (Luse-type bodies) as well as annular lamellar structures.

Female↗