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Biomedical subjects

I N Il'inskikh

Publications and source records attributed to I N Il'inskikh.

16 recordsLinked to original sources
PubMed1989

[Cytogenetic instability, the ability to produce interferon and immunoreactivity of blood lymphocytes in patients with schizophrenia].

In schizophrenia patients, the level of T-lymphocytes with cytogenetic aberrations is elevated, and the ability of these cells for PGA-blast-transformation and the interferon synthesis is reduced. The elevation of the lymphocytes ability for blast-transformation in the presence of the native preparation of DNA and for lysis of the erythrocytes proper is marked in these patients. The observed changes were especially marked in schizophrenia with an interrupted course.

Chromosome Aberrations↗
PubMed1988

[Applicability of micronucleus analysis for testing the aneuploid cell level in mouse bone marrow subjected to the action of different mutagenic factors].

The results of parallel studies in murine bone marrow of aneuploid cells' level and of micronuclei cells under the action of different mutagenic factors (X-irradiation, ethanol, measles virus and colchicine) are presented. The correlation analysis demonstrated the absence of correlation for the indices studied, in most cases. Possible reasons for this phenomenon are discussed.

Aneuploidy↗
PubMed1983

Cytogenetic disturbances and immunoreactivity in patients with measles and influenza.

The number of lymphocytes with cytogenetic aberrations is increased in patients with measles and influenza. Considerable changes in immunoreactivity of the organism can be observed during measles and influenza. Correlation analysis suggests that in measles and influenza there exists an inversely proportional connection between the number and functional activity of T lymphocytes and the level of cytogenetic disturbances in them. Indices of B immune system and the level of cytogenetic aberrations in influenza were characterized by directly proportional correlation while in measles the type of correlation depended on the intervals of observation.

Child↗
PubMed1982

[Comparative characteristics of different methods of studying the cytogenetic disturbances in the bone marrow cells of Macaca rhesus monkeys infected with the poliomyelitis virus].

It has been testified that to study the influence of viruses on cytogenetic structures of bone marrow cells of monkeys (Macaca mulatta), it is possible to use not only the traditional methods, i.e. the analysis of chromosome set and the pathologic division, but the micronuclear test as well, based on the study of polychromatophylous erythrocytes with micronuclei in the bone marrow of animals.

Animals↗
PubMed1978

[Effect of ethanol and its metabolite acetaldehyde on the chromosomal apparatus of rat and human cells].

A higher level of cells with a changed number of chromosomes in leucocyte blood culture of chronic alcohol users (drunkards) and spermatogency cells of alcoholized rats has been noticed. Ethanol metabolite acetaldehyde exerts the same influence in the leucocyte blood culture of healthy donors. A prolonged influence of ethanol on rats, and also the effect of large doses of ethanol on the leucocyte blood culture of healthy donors cause an increase in the quantity of cells with chromosome translocations and gaps.

Acetaldehyde↗
PubMedDate not supplied

[The role of the association of Opisthorchis felineus maritae with the Epstein-Barr virus in the cytogenetic sequelae of an opisthorchiasis infection].

The immunofluorescence analysis of Epstein-Barr virus (EBV) antigens in the body of Opisthorchis felineus (OF) helminths was carried out. It was found that EBV antigens located in eggs of helminth. Adding of OF antigens and/or EBV to the lymphocyte human cultures of healthy donors can induce a cytogenetic damage in cells. A role of EBV location in opisthorchis eggs in chromosome damage and cancer development is discussed.

Animals↗
PubMedDate not supplied

[Cytogenetic defects in lymphocytes of patients with chronic opisthorchiasis concurrent with Epstein-Barr virus persistence].

Sixty three patients with chronic opisthorchiasis were cytogenetically, serologically, and biochemically studied. Most patients with opisthorchiasis were found to have higher or high titers of antibodies to Epstein-Barr viral antigens. There was a direct correlation between the titers of antibodies to Epstein-Barr virus capsid antigen and the count of cytogenetically damaged cells. The majority of opisthorchiasis patients with superinvasion, hepatic, pancreatic, and oropharyngeal diseases showed a great increase in the titers of antibodies to Epstein-Barr virus antigens and a high persistence and in the cytogenetically damaged lymphocytes. Opisthorchiasis patients with high antibody titers to Epstein-Barr virus capsid antigens showed a considerable decrease in the parameters of the peripheral antioxidative system.

Antibodies, Viral↗
PubMedDate not supplied

[Relationship between the number of erythrocytes with micronuclei and immunologic status in humans].

26 persons, having high level of erythrocytes with micronuclei were distinguished among clinically healthy people. While examining their health changes were registered in the systolic and pulse pressures, number of T-suppressors and T-helpers, natural killers, level of immunoglobulins and immune complexes, phagocytosis activity and peroxidases reaction of the leukocytes. Increase in the level of the cytogenetic aberrative lymphocytes was observed in all the cases. DNA-reparative synthesis was reduced only in 5 persons.

Adolescent↗
PubMedDate not supplied

[The autoimmune process and chromosomal anomalies].

Data available in literature on the role of immune system in the cytogenetic stability of the organism are presented. A direct relation is shown to exist between immunity disturbances and changes in the number and structure of chromosomes.

Animals↗
PubMedDate not supplied

[Use of the micronucleus test in the screening and monitoring of mutagens].

Data from literature on the use of micronuclear test to determine mutagenicity in agents of physical, chemical and biological nature are presented. The objects on which this method is used most frequently are enumerated. Great attention is paid to the analysis of micronuclei in blood erythrocytes and bone marrow of animals. It is shown that the animal sex, age and the way of mutagen injection are of great importance in micronuclear testing of mutagens. Methodical papers concerning the peculiarities of fixation colour, analysis and mathematical testing are given. Mutagen factors tested by the method of micronuclear analysis are enumerated. A high resolution and small labour input of the micronuclear test are shown.

Animals↗
PubMedDate not supplied

[Role of Toxoplasma gondii in human and animal chromosomal pathology].

Toxoplasma gondii was found to cause an appearance of cells with a changed number of chromosomes in the bone marrow of infected white rats. Besides the increase of aneuploid and polyploid cells the infection with toxoplasms inhibits the mitotic activity in bone marrow of rats. The similar changes were observed in blood leucocytes of toxoplasmosis patients.

Animals↗
PubMedDate not supplied

[A decrease in the level of erythrocytes with micronuclei under the influence of pyrimidine and thiazolidine derivatives in the blood of persons who came under radiation exposure as a result of the accident at the Siberian Chemical Combine].

The authors have found that pentoxylum (pyrimidine derivative) and leucogenum (thyazolidine derivative) are capable or reducing the number of cells with micronuclei in the blood of people who suffered from the radiation accident at the radiochemical works of the Siberian chemical plant. The most effective decrease in the cells with micronuclei in adults was observed two weeks after treatment, while in children the same result was achieved with leucogenum on the third day.

Adult↗