[Exogenous allergic alveolitis in tobacco industry workers].
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Biomedical subjects
Publications and source records attributed to I N Il'ina.
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Clinicoroentgenological and functional manifestations of exogenic allergic alveolitis (EAA) have been studied in 143 patients. The disease is often masked and runs in the form of chronic nonspecific bronchopulmonary inflammation. The presence of antigen-dependent symptom complexes associated with involvement of other organs characterizes EAA more specifically. Finally, the disease progresses to parenchymatous interstitial fibrosis. Pulmonary ventilation and blood oxygen saturation are reduced.
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The experimental study made on 185 guinea pigs revealed that during the chemotherapy of destructive tuberculosis the typical bacterial forms of M. tuberculosis rapidly disappeared, but the cavities of destruction were retained and the presence of the filter-passing forms of M. tuberculosis, along with antigenemia and specific cell-mediated and humoral immunity could be detected. The use of repeated biological subculturing resulted in the reversion of the filter-passing forms of M. tuberculosis to their typical bacterial forms; simultaneously the increase of antigenemia (from subculture to subculture) and the enhancement of immune responsiveness occurred.
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Investigations carried out on CBA mice demonstrated that adult mice to which mycobacteria BCG were injected intravenously 12 months after thymectomy (in a dose of 2 mg for a period of 2 1/2 months) died of disseminated BCG infection against the background of depression of hypersensitivity of delayed type. The usual vaccine process developed in the sham-operated animals.