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Biomedical subjects

I Mutz

Publications and source records attributed to I Mutz.

At least 73 records · Page 4Linked to original sources
PubMed1977

Immunodeficiency with lymphoid hyperplasia.

A 2 1/2-year-old boy presented with recurrent respiratory tract infections, generalized lymphadenopathy and hepatosplenomegaly. Immunologic evaluation revealed a deficiency of humoral immunity. Repeated lymph node biopsies during a 10-year follow-up constantly showed excessive follicular hyperplasia with huge germinal centers consisting of germinoblasts, but lacking plasma cells. The disease can be interpreted as a subtype of the common variable immunodeficiency in which the commutation of germinoblasts to plasma cells in the evolution of B cells is blocked.

B-Lymphocytes↗
PubMed1977

[Diagnostic, therapeutic and prognostic aspects of wilms' tumour (author's transl)].

Within the last 20 years 43 children with Wilms' tumour were seen at the Paediatric Departments of the University Hospitals of Graz, Innsbruck and Vienna. Case histories, clinical details and diagnostic procedures are discussed. Since 1969 19 out of 21 children were treated according to the modern atandard regimen (operation, irradiation and cytostatic therapy for 2 years except in infants with stage I). Since 1969 the survival rate has been higher (17 out of 21 children: 81%) than in the period 1956 to 1968 (7 out of 22 children: 31.8%), when only one child (in stage I) was treated according to current concepts. The better prognosis noted in young infants of this series, as in the literature was due to the earlier stage of the disease in these infants. A further improvement in the survival rate of children with Wilms' tumour should be achieved by earlier diagnosis, thereby ensuring operability, and by cytostatic therapy during the following 2 years. This will only be possible when there is closer cooperation between surgeon, radiotherapist and oncologist. It should be possible to lower the long-term therapeutic complication rate with even more stringent observation measures and with increasing expertise of all doctors concerned.

Age Factors↗
PubMed1977

[Neuroblastoma: diagnosis, therapy and prognosis on the basis of 56 cases (author 's transl)].

Within the last 20 years 56 children with neuroblastoma were seen at the Paediatric Departments of the University Hospitals of Graz, Innsbruck and Vienna. Case histories, clinical details and diagnostic procedures are discussed. The poor prognosis (only 18 out of the 56 children i.e. 32% are still alive) is due to the high incidence of metastasis (55% of the patients were admitted in stage IV of the disease). Diagnosis within the first year of life, mediastinal localization and histological differentialtion to ganglioneuroblastoma are good prognostic features, whereas therapeutic measures are of less importance. Radical surgery still provides the patient with the best chance of survival, but is rarely feasible (complete primary removal was possible in only 7 out of the 56 patients; in futher 2 patients the tumour proved to be resectable at a 2nd look operation). Cytostatic therapy has not really increased the survival rate. At present improvement in prognosis can only be expected in case of early diagnosis of the tumour.

Adolescent↗
PubMed1976

[Angiographic disappearance of fibromuscular dysplasia of the carotid artery in childhood (author's transl)].

Fibromuscular dysplasia (FMD) of the left carotid artery was diagnosed on the basis of the typical angiographic changes in a seven-year-old girl suffering from acute hemiplegia. A repeat angiography of both carotid and renal arteries 8 months later revealed no pathological changes. The diagnosis of FMD of the carotid arteries is extemely difficult and requires a biopsy or repeat angiography for verification.

Age Factors↗
PubMed1976

[Chronic pseudomalignant immuneproliferation (Canale-Smith syndrome) (author's transl)].

A case of chronic lymphadenopathy and splenomegaly existing over a period of 11 years, with a variety of acquired deficiencies of immunity and autoimmune phenomena, is described. It is almost identical with the 5 children reported in 1967 by Canale and Smith as a new benign syndrome "chronic lymphadenopathy simulating malignant lymphoma". The relationship to similar disorders with lymphadenopathy and immunological abnormalities is discussed.

Adolescent↗
PubMed1976

[Announcement of an Austrian study group for the treatment of leukemia in children (author's transl)].

The formation of an Austrian study group for the treatment of leukemia in children with international cooperation is reported. An essential aim is the centralisation of treatment at the 3 Austrian University clinics, the St. Anna children's hospital in Vienna and other children's hospitals particularly interested in the treatment of leukemia. Secondly the group undertakes randomised therapeutic studies, at present on two new variants of the Pinkel treatment scheme. Within the first 9 months 33 cases were included in this study in cooperation with the Zagreb University children's clinic (Doz. TIEFENBACH).

Austria↗
PubMed1975

[Cytomegalovirus disease in the course of histiocytosis X (AUTHOR'S TRANSL)].

A 3 1/2 year-old boy was treated with cytostatic drugs for progressive histiocytosis X. 9 months later he acquired cytomegalovirus disease, the diagnosis being proven by liver biopsy. The causal relationship of immunosuppressive side effects of the treatment and this cytomegalovirus infection is discussed.

Child, Preschool↗