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Biomedical subjects

I Murat

Publications and source records attributed to I Murat.

115 records · Page 7Linked to original sources
PubMed1981

The efficacy of caffeine in the treatment of recurrent idiopathic apnea in premature infants.

This prospective controlled study was aimed at evaluating the efficacy of caffeine in treating recurrent idiopathic apnea in the premature infant. Eighteen preterm infants (29 to 35 weeks' gestation) were studied. Recordings during the first 24 hours and on the fifth day of caffeine treatment showed a significant decrease of severe apnea (P less than 0.01) and of mild apnea (P less than 0.001) in the treated group (group 1) as compared with the control group (group II). No treatment of apnea other than caffeine was required in group I, whereas six neonates in group II had such severe and frequent apneic episodes for more than 48 hours that withholding additional treatment was believed to be unethical. No undesirable side effects of caffeine treatment were observed.

Apnea↗
PubMedDate not supplied

Evaluation of the efficacy of a forced-air warmer (Bair Hugger) during spinal surgery in children.

STUDY OBJECTIVE: To evaluate the efficacy of a forced-air warmer during spinal surgery for correction of scoliosis in children. DESIGN: Prospective randomized study (group allocation based on the availability of the warming device). SETTING: Children's teaching hospital. PATIENTS: 51 ASA physical status I and II children (mean age, 15 years; mean weight, 45 kg) scheduled for posterior spinal fusion with general anesthesia. INTERVENTIONS: Study group (warmed; n = 26)--legs covered with the forced-air warmer (Bair Hugger, Augustine Medical, Inc., Eden Prairie, MN) after installation of the patient in prone position--versus control group (n = 25)--400W heat lamp placed over the head during surgery as is usually done in our institution. MEASUREMENTS AND MAIN RESULTS: Rectal temperature was taken every 15 minutes during surgery and during the first 2 hours in the recovery room. Time required for the wake-up test, time to extubation, and blood loss also were noted. Temperature profiles were very different in the 2 groups. In the control group, rectal temperature decreased during the first 180 minutes to a minimum of 34.8 degrees C +/- 0.6 degrees C, followed by a slow rewarming phase. In the warmed group, the lowest temperature (35.6 degrees C +/- 0.5 degrees C) was recorded 45 minutes after placement of the forced-air warmer, followed by an effective warming phase. At the end of surgery, temperature was significantly higher in the warmed group than in the control group (36.5 degrees C +/- 0.8 degrees C vs. 35.4 degrees C +/- 0.9 degrees C). However, time required for the wake-up test, time to extubation, and blood loss did not differ between groups. CONCLUSION: The forced-air warmer (Bair Hugger) is effective during spinal surgery, although only about 20% of body surface area can be covered.

Adolescent↗
PubMedDate not supplied

[Controlled hypotension during posterior vertebral arthrodesis; value of an isoflurane-nitroglycerin combination].

Eighteen young patients (mean age +/- SD 15.9 +/- 3.3) scheduled for operative treatment of idiopathic scoliosis (posterior spine fusion) were studied during surgery. Deliberate hypotension (MAP less than 60 mm Hg) of long duration (greater than 2 hours) was induced using isoflurane and nitroglycerin. Hypotension was effective in less than 15 min in all patients. The mean inspiratory fraction of isoflurane employed was 2.04 +/- 0.19% for the first operative hour, and 1.36 +/- 0.20% for the second operative hour. The difference between these inspiratory fractions is highly significant (p less than 0.001), while the rate of nitroglycerin infusion was unchanged (3 micrograms X kg-1 X min-1). Heart rate increases significantly at H1 and H2 when compared to preinduction values and the product of heart rate X systolic blood pressure decreases significantly with a mean of 30% versus preinduction values. A satisfactory operative field was obtained in all cases. Blood loss was dependent of the duration of surgery, of the total blood volume of the patient, of the length of spine fusion. For each patient, a slope of blood loss was established. The mean slope was 3.74 +/- 0.39 ml X kg-1 X h-1. The determination of the slope at the end of the first operative hour allows us to predict the total blood loss during surgery. Intra operative awakening was obtained 22.8 +/- 3.7 min after isoflurane was discontinued. Isoflurane and nitroglycerin produce a stable and safe hypotension with no major hemodynamic disturbances. Isoflurane has to be discontinued 20 min before the wake-up test.

Adolescent↗
PubMedDate not supplied

[Percutaneous catheterization. Experience in a neonatal intensive care unit].

157 percutaneous catheterizations were performed in 114 neonates. Besides the advantages of a central catheter, this easier technique allows to save the large vessels. However, the risks of severe complications (5 septicemias, 5 intrathoracic effusions of which 5 deaths) lead to strictly restrict its indications. Complications should be avoided with a perfect technique: strict asepsis and positioning of the end of catheter.

Catheterization↗