Plasma T and A were studied in 10 patients with hypercorticism. In the female patients, plasma A and T were elevated in 4 cases of Cushing's disease, slightly decreased in 2 cases of adrenal adenoma and greatly increased in I case of adrenal carcinoma. In 3 male patients, A plasma levels followed ACTH levels, but T was subnormal, irrespective of the cause of hypercorticism. Furthermore, in 8 normal men, the decrease of plasma T, observed after ACTH administration, was not directly related to ACTH, but rather to cortisol, as it was not observed after metyrapone induced ACTH increase. As no change in LH secretion was shown and as dexamethasone reduced the testosterone response to HCG, it seems likely that glucocorticoids act directly on testosterone biosynthesis.

Adrenal Cortex Neoplasms↗

PubMedDate not supplied

[Prolactin-secreting adenomas in males. Study of the hypophyseal-gonadal axis].

The pituitary gonadal-axis has been studied in 25 cases of PRL-secreting adenomas in men. Besides impotence, infertility, arrest or lack of puberty may be observed, basal levels of LH and FSH are in the low normal range but a weak increase of LH is observed after LH-RH. Testosterone (T) levels are low in most of the patients and only normal in 5. In two cases with actively secreting-PRL adenomas, normal circadian rhythms of T and PRL are abolished. After CB 154 treatment, an improvement of the clinical and biological symptoms is observed in 8 out of 10 men. An increase of LH response to LH-RH under CB 154 is obtained in 5 cases. This is in favour of a functional effect of the hyperprolactinemia on the pituitary.

Adenoma↗

PubMedDate not supplied

[Plasma levels of testosterone production in male thyrotoxicosis].

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Adolescent↗

PubMedDate not supplied

[Testosterone binding activity in the serum of women with idiopathic hirsutism].

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Binding Sites↗

PubMedDate not supplied

[The study of the influence of prolactin on gonadal steroids metabolism by the human chorionic gonadotropin test. Plasma and urinary determinations in 27 subjects (control, hyperprolactinemic, normoprolactinemic but hypogonadic subjects) (author's transl)].

In order to determine whether hyperprolactinemia besides its action at the hypothalamic level, acts at the gonadal level, a serie of 28 stimulations by Human Chorionic Gonadotropin (HCG : 5 000 IU X 3) is reported. The following parameters were measured in plasma and in urine before and during 4 consecutive days following the injection of HCG : Progesterone (P), 17 OH Progestérone (17 OHP), Androstenedione (A), Testostérone (T), Dihydrotesterone (DHT), Estrone (E1), 17 beta estradiol (E2), Urinary Androstanediol (Adiol) Testosterone Glucuronide (G.T.) and phenolsteroids (PS). The test was performed in both sex, in 3 different groups including normal, hyperprolactinemic and normoprolactinemic but hypogonadic subjects (hypopituitarism). These data suggest that in hyperprolactinemic subjects: there is no steroid 5 alpha reductase abnormality in male patients, and there is no gonadal resistance to HCG stimulation in both sex, at least to the high doses of HCG used in this study.

Chorionic Gonadotropin↗