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Biomedical subjects

I Morton

Publications and source records attributed to I Morton.

10 recordsLinked to original sources
PubMed2006

Differentiation and immune function of human dendritic cells following infection by respiratory syncytial virus.

RSV causes annual epidemics of bronchiolitis in winter months resulting in the hospitalization of many infants and the elderly. Dendritic cells (DCs) play a pivotal role in coordinating immune responses to infection and some viruses skew, or subvert, the immune functions of DCs. RSV infection of DCs could alter their function and this could explain why protection after natural RSV infection is incomplete and of short duration. In this study, this interaction between DCs and RSV was investigated using a human primary culture model. DCs were generated from purified healthy adult volunteer peripheral blood monocytes. Effects of RSV upon DC phenotype with RSV primed DCs was measured using flow cytometry. Changes to viability and proliferation of cocultured DCs and T-cells were determined using microscopy with fluorescent dyes (Hoechst 33342 and propidium iodide). DC maturation was not prevented by the RSV challenge. RSV infected a fraction of DCs (10-30%) but the virus replicated slowly in these cells with only small reduction to cell viability. DCs challenged with RSV stimulated T-cell proliferation less well than lipopolysaccharide. This is the first study to demonstrate RSV infection of human monocyte derived DCs and suggests that the virus does not significantly interfere with the function of these cells and potentially may promote cellular rather than humoral responses.

Adult↗
PubMed1992

Validation therapy: extracts from 20 groups with dementia sufferers.

Validation therapy, an interactive and group technique for people with dementia, is described. Excerpts from the transcripts of 20 validation therapy groups are presented. These demonstrate the surprising ability of the group members (all moderately demented) to share feelings and problems, follow a theme and utilize facilitating skills in the group setting. The contrast between the group members' behaviour outside the group and that in the group is discussed and future research is proposed. The authors conclude that such groups constitute an exciting new therapy for those with dementia.

Aged↗
PubMed1991

Following in the right footsteps.

An initiative which targets resources towards chiropody patients with the greatest needs has been taking place in Nottinghamshire during the past three years. Ian Morton and Peter Pratt describe its progress and outline its new goals.

Costs and Cost Analysis↗
PubMed1988

Validation therapy with the demented elderly.

This paper describes validation therapy--a method of communicating with disorientated people through the use of specific interactive techniques. It is compared with reality orientation as this is the most widely used therapy for demented patients. The method of evaluating the effects of validation group therapy is included. The authors suggest that validation therapy is an exciting and important therapeutic development which can restore self-worth and ease the stress suffered by elderly people with dementia.

Aged↗
PubMedDate not supplied

Validation therapy: a review of its contribution to dementia care.

There has been a great deal of interest in validation therapy (VT), an interactive technique and group therapy for people who are disoriented. This article reviews the strengths and development of VT and acknowledges Naomi Feil's contribution to the care of those with dementia. Techniques for communicating with people who are dysphasic are described, as are therapeutic interventions which address the devastating effects of memory loss on the sufferers' sense of self and identity.

Communication↗