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Biomedical subjects

I Morild

Publications and source records attributed to I Morild.

43 records · Page 3Linked to original sources

Radiotherapy and resection for apparently inoperable rectal adenocarcinoma.

Sixty-seven patients with primary, apparently inoperable rectal adenocarcinomas were referred for radiotherapy from a defined geographic region in Norway during the period from 1976 to 1981. Fifty-five were without detectable metastasis at referral and were potentially resectable. Patients were given high energy radiation towards abdominal chimney or pelvic fields to a dose of 3150 rads. Resection was attempted after three weeks. Additional radiotherapy was given to both resected and nonresected patients to a NSD (nominal standard dose) of 1400 to 1560 ret (rad equivalent therapy). At full radiation dose, nonresected patients were reexamined, and in some explorative laparotomy with resection was attempted. Twenty patients had radical resections in the pelvis, but five of them had moderately advanced distant metastasis. Nine patients are disease-free at 12+ to 76+ months. Although the overall prognosis for the patients with apparently inoperable rectal adenocarcinomas remains poor (median survival 12 months), some patients can achieve long-term disease-free survival after combined radiotherapy and surgery. Patients with moderately advanced metastasis can enjoy a better of quality of life without local symptoms following the combined treatment.

Adenocarcinoma↗

Metastasizing neuroectodermal tumour.

This report describes a medulloblastoma with extracranial metastases in a 24-year-old man. Postoperatively, 60Co irradiation was given and clinical recovery was good. Cervical lymph node metastases developed 2.5 years later. The patient received cytostatic treatment and a second course of radiation therapy with 60Co and lived for 6 years after the onset of symptoms, finally dying with signs of bronchopneumonia. The possible routes of spread are discussed.

Adult↗

Juxtaglomerular apparatus in the domestic fowl (Gallus domesticus).

The juxtaglomerular apparatus in the kidney of the domestic fowl was studied with the light and electron microscope after fixation by vascular perfusion. The height of the macula densa cells was greater and the internuclear distance less than were those of other distal tubule cells. Goormaghtigh (lacis) cells were found in the angle between the hilar arterioles and the glomerulus. The branching pattern of the basement membrane of the macula densa was extensive, surrounding both the Goormaghtigh cells and the mesangial cells. The basement membrane ended in the walls of both hilar arterioles and in the glomerular capillaries. Thus, all juxtaglomerular and glomerular structures were linked together by the branches of basement membrane. The afferent and efferent arterioles were often found ramifying in the mesangial cell mass. Granular epithelioid cells and adrenergic nerves were found within the glomerulus.

Animals↗

Coronary artery surgery with the right gastroepiploic artery: optimal routing sites through the diaphragm.

A possible problem in coronary artery surgery with the right gastroepiploic artery (GEA) is kinking of the GEA at the tunnel through the diaphragm. This study was performed to find the best routes through the diaphragm to different coronary branches. The freed gastroepiploic pedicle was filled with contrast and routed posterior to the pylorus. The right coronary artery (RCA), the left anterior descending artery (LAD), and the largest marginal branch were also filled with contrast. One diaphragmatic incision was made close to the vena cava (paracaval), another anterior to the esophagus (ante-esophageal) and a third close to the diaphragmatic vein. By each route the GEA was directed towards each coronary artery. In each position the occurrence of kinks and the length necessary to reach the coronary artery was studied. The most preferable combinations of diaphragmatic incision and grafting site were the paracaval incision for the RCA system and the ante-esophageal incision for marginal branches.

Arteries↗

Hemangiopericytic meningioma with extracranial spread to multiple sites without intracranial recurrence.

This report describes a hemangiopericytic meningioma with extracranial metastases in a 46-year-old man. Metastases developed in his right femur 2 1/2 and 4 1/2 years post operation; he received radiotherapy both times. Now 5 years after the primary operation the patient is alive but shows signs of a subcutaneous tumor in the area of the right posterior iliac crest, most likely metastatic tumor tissue. The case is discussed with special attention paid to the path tumor spread.

Femoral Neoplasms↗