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Biomedical subjects

I Moriguchi

Publications and source records attributed to I Moriguchi.

At least 37 records · Page 2Linked to original sources
PubMed1986

Albumin-induced changes of fluorescence spectra of 1-pyrenebutyric acid.

Changes in the fluorescence spectra and quantum yield of 1-pyrenebutyric acid (1) induced by human, bovine, rabbit, and dog serum albumins and healthy adult serum, liver-disease patient serum, and renal-disease patient serum were compared at pH 7.4. Human serum albumin, healthy adult serum, and liver-disease patient serum caused marked quenching of the fluorescence of 1-pyrenebutyric acid. On the contrary, bovine, rabbit, and dog serum albumins increased the fluorescence intensity. Renal-disease patient serum also enhanced the intensity but caused quenching of the fluorescence after treatment with charcoal. Thus, 1-pyrenebutyric acid clearly shows interspecies differences in the environment or the structure of the binding site on serum albumin between humans and other animals. Furthermore, it is suggested that some substance which influences the character of the binding site for 1-pyrenebutyric acid exists in the serum of renal-disease patients.

Animals↗
PubMed1986

Structure-activity studies of 4,6-disubstituted 2-(morpholinocarbonyl)furo[3,2-b]indole derivatives with analgesic and antiinflammatory activities.

4,6-Disubstituted 2-(morpholinocarbonyl)furo[3,2-b]indole derivatives showed analgesic and antiinflammatory activities when assayed by the acetic acid writhing test in mice and the carrageenin edema test in rats. To understand how the substituents affect the biological activities, the quantitative structure-activity relationships (QSAR) of 38 compounds were analyzed using the adaptive least-squares method (ALS method). The resulting QSAR suggested that some chemical modifications of 4,6-disubstituted furo[3,2-b]indole derivatives would improve their biological activities. Thus, 15 additional compounds were synthesized to reinforce and confirm the correlation. Among these compounds, particularly 4-(2-ethylhexanoyl)-2-(morpholinocarbonyl)-6-(trifluoromethy l) furo[3,2-b]indole showed pronounced biological activities. This compound gave a pharmacological activity spectrum similar to that of tiaramide but exhibited much higher potency.

Animals↗
PubMed1981

A study of schizophrenic brains by computerized tomography scans.

The brains of 55 schizophrenic patients and 65 controls were examined using computerized tomography scans. The width of the interhemispheric fissure and the third ventricle, and the volume of the lateral ventricles in the schizophrenic patients were significantly larger than those obtained in the controls. The extension of the width of the interhemispheric fissure and the increase in the volume of the lateral ventricles in the schizophrenic patients were assumed to be caused not by aging but by the schizophrenic illness itself. The increased in the volume of the lateral ventricles and the area of the anterior horns of the lateral ventricles in the schizophrenic patients was assumed to be related to the schizophrenic pathogenesis.

Adolescent↗
PubMed1980

Adaptive least-squares method applied to structure--activity correlation of hypotensive N-alkyl-N''-cyano-N'-pyridylguanidines.

A method using an adaptive least-squares (ALS) technique has been developed for the discrimination of ordered categorical data. The method (ALS method) has the advantages of simultaneously considering any number of classes and of producing a single discriminant function which can place patterns in several classes. The ALS method was compared with linear discriminant analysis (LDA) in application to the problem of discriminating three-class hypotensive therapeutic indices of 76 N-alkyl-N''-cyano-N'-pyridylguanidines using nine descriptor variables. With the full data set and in the five leave-out runs, it was shown that the ALS method was superior and more stable in recognition and prediction. The structure--activity relationship is discussed on the basis of discriminant functions formulated.

Antihypertensive Agents↗