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Biomedical subjects

I Moraru

Publications and source records attributed to I Moraru.

84 records · Page 5Linked to original sources
PubMedDate not supplied

Ultrastructural peroxidase pattern indicating cellular maturity in myelomonocytic leukaemia.

The ultrastructural pattern of endogenous peroxidase of monocytes has been investigated in bone marrow samples as well as in the blood of patients labelled as myelomonocytic leukaemia (MML) after clinical and laboratory investigation. The predominance or the exclusive presence of a granular pattern in the bone marrow proved to be consistent with chronic MML cases. On the other hand, the presence of the peroxidase in RER, nuclear envelope, Golgi complex and granules in the bone marrow and even in the peripheral blood occurred in acute MML patients.

Blood Cells↗
PubMedDate not supplied

Dysfunctional endometrium in primary and secondary sterility. An optic and electronmicroscopic study.

Endometria from women with primary and secondary sterility were morphologically, optically and ultrastructurally studied; such endometria were selected by clinical and paraclinical methods. In dysfunctional endometria the most important modification consists in the perturbation of the cyclical maturation process of the epitheliostromal components, perturbation which may take place "synergically" or it may be "dissociated", in disagreement with the theoretic day of the menstrual cycle. Such perturbations took place in varied circumstances: "out of phase", luteal deficit associated with hyper- or hypoestrogenemia, or pure luteal deficit, receptivity disorders, association with specific or unspecific inflammatory lesions, anovulatory cycle. Endometrium biopsy constitutes the best method for the diagnosis of endometrial dysfunctions, showing both the ovary's global hormonal function, and the qualities of the endometrial receptor, with the corrective of the corresponding technical processes and the compulsory knowledge of some clinical data.

Adult↗
PubMedDate not supplied

Caffeine effects on the chromosomal aberrations induced in vivo by sarcolysine and methotrexate.

Wistar adult rats bearing Guérin T8 ascite tumours were intravenously inoculated with 3 mg/kg b.w. sarcolysine and respectively 5 mg/kg b.w. methotrexate on the 7th day after ascite cells grafting. Four hours after cytostatic administration, 5 mg/kg b.w. caffeine was intravenously given. Cytogenetic observations concerning the frequency and the type of induced chromosomal aberrations were performed 24 hrs after cytostatic administration, both in the animals treated with only sarcolysine, methotrexate and caffeine and in those double-treated with cytostatics and caffeine. Chromosome examinations were also performed in untreated controls. Both in the sarcolysine- and methotrexate- treated tumors, the induced chromosome lesions were enhanced by caffeine administration, but this effect was very obvious in the methotrexate experiments and rather weak in the sarcolysine treatments (see table). This different effect of caffeine might be due to the different mechanisms by which sarcolysine and methotrexate are interfering in DNA replicating processes.

Animals↗
PubMedDate not supplied

Beta2-microglobulin excretion and autoimmune phenomena in endemic Balkan nephropathy.

Quantitative determinations of beta2-microglobulins were carried out in 335 urinary samples collected from 335 subjects living in villages with a high rate of morbidity and mortality from endemic Balkan nephropathy. Three months after the first determination of beta2-microglobulin excretion, blood and urine samples were obtained from 19 patients with high values and from 19 with normal values of beta2-microglobulins. The results of the biochemical and immunological investigations performed on these samples suggest that the tubular alteration is the first lesion. The autoimmune phenomena elicited by the tubular alteration may contribute, by an antigen-antibody complex disease mechanism, to the appearance of glomerular secondary lesions.

Antigen-Antibody Complex↗
PubMedDate not supplied

Augmentation of CD8 and CD4 lymphocytes subsets in AIDS infected children after treatment with a non-toxic chelating agents compound--Rodilemid.

Twelve children were included into the protocol, 5 in March 1989 and 7 in April 1993. All of them were HIV 1 positive and had diarrhoea, important adenopathy and opportunistic infections. Seven out of 12 patients had an immunological monitoring. One out of 12 children with B hepatitis died with liver cirrhosis. Eleven children had a clear improvement in their clinical course, during the treatment. Five out of 7 patients had a significant increase of the CD4 lymphocytes at 4 and 7 months follow-up. Four patients had an important and significant increase of the CD8 count at 4 months and 6 out of 7 patients at 7 months. Interestingly, in 4 out of 7 patients after 7 months treatment we observed higher than normal value of the CD8 count. Variations observed for CD8 population compared to CD4 were more important.

AIDS-Related Opportunistic Infections↗