[Theoretical considerations on the natural variability of influenza virus].
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Biomedical subjects
Publications and source records attributed to I Moisa.
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Investigations were conducted during 1985 and 1986 years on the effect of some chemicals on the parainfluenza and adenovirus circulation in an industrial enterprise community. The presence of type 1, 2 and 3 parainfluenza virus and of adenovirus was revealed by immunofluorescence in exfoliated cells collected from nasopharynx. The kinetic of specific hemagglutination inhibiting and complement fixing antibodies was followed monthly by immunological tests. Meaning of the results is discussed from an epidemiological point of view.
Investigations were conducted during 1985 and 1986 years on the effect of some noxious chemicals on the influenza virus circulation in an industrial enterprise community. The presence of influenza virus type A (H1N1), A (H3N2) and B was revealed by immunofluorescence in exfoliated cells collected from nasopharynx. The kinetic of type specific hemagglutination inhibiting antibodies was followed monthly. Chick embryos were used to isolate influenza virus strains. Meaning of the results is discussed from an epidemiological point of view.
Treatment of mice with different cellular nucleic acids prior to inoculation of influenza virus A/PR8/34 (H1N1) conferred--in some cases--a nonspecific protection against the experimental infection. The optimal amount of nucleic acid was 400 micrograms/mouse, irrespective of the origin or type of the macromolecule.
Investigations on the presence of cyanophages in the fresh and sea waters of Romania resulted in the isolation of 31 strains. The host range of the cyanophage isolates showed some particularities as compared with classical cyanophages types. The electron optic study of the cyanophage strains grown in Phormidium sp. revealed the presence of three types of virus particles, differing as regards their tail length, with a morphology similar to that of T-odd coliphages.
Electron microscopic studies were performed on the sequence of morphological alterations induced by the cyanophage PP-1 in the blue-green algae Phormidium sp. and Plectonema boryanum. The following phases of virus infection were made evident: virus adsorption onto the host cell; the presence of virus "ghosts", suggesting the penetration of viral DNA into the cell and its multiplication in the nucleoplasm; invagination of thylakoids and formation of the "virogenic stroma"; virus maturation within the "virogenic stroma"; cellular lysis at 48 hours post inoculation.