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Biomedical subjects

I Miyoshi

Publications and source records attributed to I Miyoshi.

At least 361 records · Page 20Linked to original sources
PubMed1976

Non-African Burkitt's lymphoma in a young woman.

Non-African Burkitt's lymphoma is presented in a 29-year-old, unmarried woman, who developed tumors in both breats and ovaries, ascites and pleural effusion. Assessment of B cells in the tumor cells, derived from ascites, pleural effusion and tumor tissue is 90%, surface IgM being consisted of 86%, in an average. Histologically, the tumor tissue demonstrates prominent, socalled starry-sky effect, and cytologically, tumor cells are poorly-differentiated lymphocytoid cells in their feautures.

Adult↗
PubMed1976

Down's syndrome: karyotypic stability of trisomy 21 in an established lympho-blastoid cell line.

A trisomic lymphoblastoid cell line derived from the peripheral blood of a patient with Down's syndrome was sequentially analyzed for chromosome constitution for 16.5 months of continuous culture in vitro. The cell line was found to maintain a modal chromosome number of 47 with trisomy 21. Parallel studies of modal chromosomes before and after banding procedures revealed no structural abnormalities except trisomy 21.

Cell Line↗
PubMed1976

Direct implantation of Ph1 chromosome-positive myeloblasts into newborn hamsters.

Peripheral leukocytes from a male patient with chronic myelogenous leukemia in blast crisis were implanted directly into the intraperitoneal cavity of seven newborn hamsters treated with antilymphocyte serum. At sacrifice 17-19 days after implantation, three hamsters were found to have disseminated tumors. The other four hamsters were cannibalized. Chromosome analysis of cells from the enlarged lymph nodes revealed the presence of a human male karyotype. Most metaphase cells were pseudodiploid with the Ph1 chromosome and isochromosome 17, while a few metaphase cells were classically diploid. Identical chromosome constitutions were observed in the original peripheral leukocytes of the patient. The results strongly suggested simultaneous heterotransplantation of Ph1-positive leukemic and normal leukocytes.

Animals↗