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Biomedical subjects

I Mincu

Publications and source records attributed to I Mincu.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

Insulin antibodies in diabetics receiving a single type of insulin.

Insulin antibodies were studied in 77 patients with diabetes mellitus who received a single insulin type from onset of treatment (12 crystalline insulin, 26 Novo Lente insulin, 7 HG insulin, 6 Komb insulin, 5 Long insulin, 17 Monocomponent Semilente insulin, 4 Monocomponent Lente insulin). The mean antibody titers in the patients treated with highly purified preparations were close to those found after treatment with conventional insulins. Correlations are established between the antibody titer and duration of diabetes, insulin requirements, and degree of metabolic stability. The relationship with diabetic complications was difficult to define but not improbable.

Adolescent↗
PubMedDate not supplied

Half-life and hypoglycemic effect of intravenous insulin in patients with diabetic ketoacidosis.

Intravenous insulin (0.3 U/kg body weight) was administered at 2-hour intervals to 34 patients with diabetic ketoacidosis (21 women and 13 men; average age 34.4 years). Determination of blood glucose and plasma insulin values after the first two hours of treatment showed a decrease of both glycemia and plasma insulin values after the first two hours of treatment showed a decrease of both glycemia and insulinemia. Insulin half-life was longer (15 min) than it is generally assumed (4--5 min). Discontinuous i.v. administration insulin in doses adapted to the "resistance to insulin" is deprived of risks, easy to apply and as effective as continuous i.v. infusion.

Adolescent↗
PubMedDate not supplied

Metabolic "responders" and "non-responders" to muscular exercise in diabetes.

The metabolic effects of muscular exercise (bicycle ergometer, 75 watts, 15 min) were studied in 16 healthy controls and 49 diabetics distributed into three groups. The first two groups included insulin-dependent diabetics three hours after administration of insulin (group A, 24 cases) or 12--18 hours after the last insulin dose (group B, 18 cases). Group C included 7 non insulin-dependent diabetics. According to the glycemia response, the patients were listed as: high responders (greater than 20% below the initial values), low responders (10-20% fall) and non-responders (increase or less than 10% decrease). The data obtained show that, in most cases, in the presence of insulin, exercise has a hypoglycemic effect and, in its absence, a hyperglycemic one. To a lesser extent, the fall in glycemia may be attributed to an apparently insulin-independent mechanism. Exercise can only be indicated (in high-responders) or contraindicated (in non-responders) after a routine tolerance test.

Adolescent↗
PubMedDate not supplied

Behaviour of insulin antibodies in diabetics treated with different insulins.

Determinations of insulin antibodies in 116 insulin-dependent diabetics treated successively with various types on insulin and in a group of 55 diabetics who received a single insulin type from the onset of the disease, revealed higher titers in those under treatment with conventional insulins, particularly Insulin Novo Lente. The mean titer of insulin antibodies is considered to be related to the insulin demands and sometimes to the length of disease. The presence of antibodies was also recorded after administration of highly purified insulins, but much more seldom and with lower titers, which could be an argument for a wider utilization of such products.

Adolescent↗
PubMedDate not supplied

Data processing system for the Centre of Nutrition and Metabolic Diseases.

The paper is devoted to the functional specification and the architecture of a data processing system to database generation and management within the Centre of Nutrition and Metabolic Diseases in Bucharest. The main operations performed by the system refer to: --Patient admission. A patient file which is created for any new patient, contains all the details hitherto included in the patient registration form. --File update, carried out periodically or whenever required. Any new relevant detail is added to the existing file in a conversational manner. --Report generation. The reports are produced periodically or upon request. --Inventory and stock control concerning the drugs dispensed free of charge. --Data processing and classification. --Creation and retrieval of patient archives. --Display on request of the various details contained by the patient file. The described system can be implemented on an INDEPENDENT I-100 general purpose minicomputer, having a main memory of 96 kwords. The disc-based AMS operating system is used. The system operates in real time, although off-line background jobs can be run in order to assist the scientific work. A FORTRAN compiler is part of the operating system.

Computers↗
PubMedDate not supplied

Study of some serum protein fractions in various clinical forms of diabetes mellitus.

With a view to studying the eventual alterations of protein metabolism, some serum protein fractions such as: immunoglobulins (IgG, IgA, IgM), transferrin and ceruloplasmin were determined in 100 diabetics (52 males, 48 females) in comparison with a control group of 26 healthy subjects. Significant differences were found between IgA and transferrin values both in diabetics and in controls. IgA tended to increase with the length of disease, whereas IgG, IgM and transferrin showed a contrary trend. IgA and transferrin values were higher in the patients with juvenile and young adult diabetes, as compared to maturity onset and senile diabetes. Other immunoglobulin and transferrin changes were related to sex, age, type of treatment, degree of stability, presence of chronic complications. No significant anomalies were found for ceruloplasmin. The results confirm the presence of serum protein alterations in diabetes mellitus, whose significance may be correlated with the clinical particularities of the disease.

Adult↗
PubMedDate not supplied

Data processing system for the centre of nutrition and metabolic diseases.

The paper is devoted to the functional specification and the architecture of a data processing system to database generation and management within the Centre of Nutrition and Metabolic Diseases in Bucharest. The main operations performed by the system refer to: -Patient admission. A patient file which is created for any new patient, contains all the details hitherto included in the patient registration form. -File update, carried out periodically or whenever required. Any new relevant detail is added to the existing file in a conversational manner. -Report generation. The reports are produced periodically or upon request. -Inventory and stock control concerning the drugs dispensed free of charge. -Data processing and classification. -Creation and retrieval of patient archives. -Display on request of the various details contained by the patient file. The described system can be implemented on an INDEPENDENT 1-100 general purpose minicomputer, having a main memory of 96 words. The disc-based AMS operating system is used. The system operates in real time, although off-line background jobs can be run in order to assist the scientific work. A FORTRAN compiler is part of the operating system.

Computers↗
PubMedDate not supplied

Micro- and macroangiopathies and other chronic degenerative complications in newly detected diabetes mellitus.

The study of 10,000 patients with newly discovered diabetes mellitus registered on the files of the Center of Nutrition and Metabolic Diseases--Bucharest between January 1974 and June 1979, revealed the presence of various types of micro- and macroangiopathies manifested by electrocardiographic alterations on 42.3%, peripheral arteriopathies in 11.2% and diabetic retinopathy in 11.2% cases, as well as renal complications in 14.5% and diabetic neuropathy in 11.62% of the cases. The significance of these complications is discussed in relation to the length of the prediagnostic period and interpreted in the light of modern knowledge concerning the chronic complications of diabetes.

Adult↗
PubMedDate not supplied

Early cystinuria, a risk factor for metabolic urolithiasis.

The levels of urinary amino acids (cystine, amino acids with basic character, branched chain amino acids and phenylalanine) were determined in the 24 hr urines of 5,500 newborns and in 20 subjects ranging in age from 2.5 to 20 years, with a suspicion of metabolic diseases. Seven newborns have shown a biochemical pattern of cystinuria. The urinary cystine levels in the first days of life appeared to correlate with an increased risk of developing, at the adult age, metabolic mono- or bilateral urolithiasis.

Adolescent↗
PubMedDate not supplied

The relationship between the urinary level of some amino acids and the occurrence of metabolic diseases associated with psychic disorders.

Assays of the branched chain amino acids, of those with basic character, of phenylalanine and glutamic acid were performed in the 24 hrs urines of 50 patients with psychic disorders, ranging in age from 0 to 20 years, and in 30 normal controls. Similar investigations were carried out in the patients' parents. Abnormal levels of urinary amino acids in some of the adults suggested the existence of mutant genes in one or both parents of one or two descendents with mental handicap. The levels of urinary amino acids correlated with the severity of the predominant psychic manifestations, which were more severe in the cases with a wide deviation from normal of aminoaciduria.

Adolescent↗
PubMedDate not supplied

The hair levels of unsaturated fatty acids (oleic, linoleic, and linolenic) indicators of the lipid metabolic balance.

The lipid metabolism was evaluated using a new method for assay of the hair contents in unsaturated fatty acids. Determinations in various hair segments and in the blood serum were performed before and after a hypolipemic diet and drug therapy in hypercholesterolemic patients in comparison with a control group. The correlation factors between the levels of the oleic, linoleic and linolenic acids in the serum and those in the hair were +0.967, +0.987 and +0.992, respectively. The method provides information on the therapy influence on the lipid metabolism variations within several weeks or months.

Adult↗
PubMedDate not supplied

Diabetic gangrene: medical and surgical causes and consequences.

Diabetic gangrene is the chronic complication which involves many medical, economic and social problems. In this study we have analyzed the medical and surgical causes and consequences of diabetic gangrene on three groups of patients: 120 patients (96 males and 24 females; aged (X +/- SD) 57 +/- 14 years hospitalised in the Clinic of Diabetes, Nutrition and Metabolic Diseases of the "N. Paulescu" Institute, 72 patients (59 males and 13 females; mean age 60 +/- 10 years) hospitalised in the Surgical Clinic of Cantacuzino Hospital; 29 patients (23 males and 6 females; mean age 58 +/- 11 years) hospitalised in the Cardiovascular Department of Fundeni Hospital. The analyses of data obtained showed: in 77% of cases the initial lesions might have been avoided by an appropriate education programme of the patients; in 66% of cases the progression of lesion from medical to surgical stage was caused by tardily coming of patient to physician; average duration of hospitalization was 27 days in the Clinic of Diabetes, Nutrition and Metabolic Diseases, 33 days in the Clinic of Surgery of "Cantacuzino" Hospital and 25 days in Cardiovascular Department of Fundeni Hospital; the surgical mortality was 8%; 47% operated patients were cured and 53% were incompletely cured and required more out patient care; 35% were thigh amputations, that shows the high invalidity potential of diabetic gangrene; the cost of medical and/or surgical care of diabetic gangrene is higher than the cost of hospitalisation for other patients; the diabetic gangrene predominantly neuropathic was better cured and the arteriopathic component breaks the medical curing and impose high amputations; diabetic gangrene is more frequent with older people, but with young people it is a cause of early retiring and psycho-social concern.

Aged↗
PubMedDate not supplied

The relationship between aminoaciduria and plasma hemoglobin levels.

Investigations in newborns, children and young adults have revealed an inverse proportion between aminoaciduria and plasma hemoglobin (Hb) levels. Values above normal were recorded for alanine, leucine, valine, phenylalanine and glutamic acid, correlating proportionally with their increased blood levels, and preceding or being concomitant with the decrease of plasma Hb, both during the first 20 months of life and in young adults. The return to near normal values of aminoaciduria occurred generally only after an early treatment with minerals, vitamins and trace elements (Supradyn), activators of the enzymes involved in the amino acid metabolism. After treatment, the Hb levels also became almost normal. An early re-equilibration of the amino acid metabolism can prevent the risk of developing, at the adult age, certain anemias and other diseases (rachitism, mental handicap, urinary infections, conjunctivitis, stomatitis, a.o.). The correlation factor was r = 0.964 and the differences between the data recorded in patients and in controls were statistically significant (p < 0.01).

Amino Acid Metabolism, Inborn Errors↗
PubMedDate not supplied

Insulin resistance: the link between impaired glucose tolerance, body mass index and plasma lipids.

Body mass index defined as weight (Kg)/height (cm2) and plasma lipids (total lipids-TL, triglycerides-TG and cholesterol-CH) were determined in 131 patients (61 males and 70 females aged between 21 and 63 years) with impaired glucose tolerance (IGT) defined according to WHO criteria. Blood glucose (BG) values and plasma insulin (PI) levels (radioimmunological assay) were determined during 2 hours OGTT with samples obtained before and after 1 h and 2 h after the intake of 75 g glucose. The sum of blood glucose and plasma insulin levels (0 + 1h + 2h) were compared in each of the following 5 groups of subjects: A--25 cases with IGT but without obesity (BMI: 23.2 +/- 2.6) and hyperlipidaemia (PL: 627 +/- 112; TG: 102 +/- 109 and CH: 208 +/- 35 mg/dl); B--35 cases with IGT and obesity (BMI: 31.2 +/- 2.6) but without hyperlipidaemia (PL: 807 +/- 109; TG: 136 +/- 31 and CH: 254 +/- 41 mg/dl); C--23 cases with IGT and hyperlipidaemia (PL: 1013 +/- 217; TG: 214 +/- 85 and CH: 311 +/- 52 mg/dl) but without obesity (BMI: 25.4 +/- 1.9); D--48 cases with IGT and both obesity (BMI: 30.9 +/- 2.8) and hyperlipidaemia (PL: 1457 +/- 155; TG: 597 +/- 188 and CH: 483 +/- 184 mg/dl); a control group of 49 cases without IGT, obesity (BMI: 26.2 +/- 1.9) or hyperlipidaemia (PL: 726 +/- 99 mg/dl).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗