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Biomedical subjects

I Mikó

Publications and source records attributed to I Mikó.

At least 19 recordsLinked to original sources
PubMed1990

Experimental study of parenteral nutrition and of the exocrine function of the pancreas.

The effect of parenteral nutrition on the pancreatic secretion was studied under experimental conditions. Experiments were carried out in 24 mongrel dogs. In all animals pancreatic fistulas were created for collection of pancreatic juice. Subsequently, in three groups (6 dogs in each) parenteral nutrition via a catheter enterostomy was applied in three different segments of their small bowels, while collecting the pancreatic juice. Group IV served as control where no parenteral nutriment was administered. The amount, pH, protein and enzyme levels of the pancreatic juice secreted during 4 hours were studied in all groups. The experiments revealed that parenteral nutrition at the initial segment of the jejunum enhanced pancreatic secretion, while this was not experienced in the other groups. The effect is assumed to be humoral, rather with a secretin-like stimulation. Based on the experimental results, the authors call attention to the fact that, during treatment of acute pancreatitis, if a feeding enterostomy is constructed for calorie intake, it should not be performed within the first metre of the jejunum.

Animals↗
PubMed1990

Experience obtained during liver resections made under experimental conditions by a telescopic compressor (AKE).

Liver resection experiments in dogs made by the AKE telescope compressor are reviewed. It is established that the instrument can be applied to the liver parenchyma of varying size and compressibility. The time of resection is short and the intervention entails only minimal loss of blood. Using this solution, it is not necessary to produce the transitory warm ischaemia of the liver.

Animals↗
PubMed1990

Partial splenectomy performed by a special technique in dogs.

Closure of the splenic surface is solved at splenectomy by placing a raw of sutures using a double thread inserted at the same level by two straight needles. This technique does not require interpositions with a good haemostasis and so favours wound healing. It does not need many instruments and is easy to perform.

Animals↗
PubMed1987

Experimental study of autologous free omental grafts.

The fate of intraabdominal free omental grafts was studied in 15 dogs and it was found that a connection between the hollow organ and the transplanted omentum was established only when the former had been injured. The larger, pigeon-egg-sized free fatty omental grafts became necrotic already from the fourth day onwards being replaced by an abscess-like structure, while in thin membrane-like grafts tissue necrosis due to the creeping in of connective tissue was less marked. In both cases, an intact, omentum is creeping over the graft from the adjacent region, i.e. the ultimate covering is actually provided by the pedicle graft.

Animals↗
PubMed1986

Restoration of skin defects with fibrin glue.

After experiments with absorbable bioplasts for substitution of skin defects, this time the absorbable fibrin glue named Tissucol was used by the authors. The experiments on 22 dogs unanimously proved that, beneath the layer of tissue adhesive, scarring occurred free of inflammation as compared to the controls where inflammatory phenomena were not excluded. The procedure has been found good and useful in high-degree burns and injuries up to their final management.

Animals↗
PubMed1986

Data on renal hypothermia by the venous passage.

The temperature values obtained in renal hypothermia through the venous circulation were biometrically analysed. It was found that there could be even about 4 degrees C temperature differences between the lower and upper poles of the kidney, always as large as 4 degrees C could be elicited in the first five minutes of hypothermia, the lower pole being colder. Similar but smaller differences were observed in ten minutes' hypothermia.

Animals↗
PubMed1986

Partial experimental autotransplantation of the spleen.

The authors performed autotransplantation of the spleen in 45 dogs. They found that, the pieces of the transplanted spleen underwent necrosis, but new malphigian bodies formed on their surface. These latter took over the sepsis-inhibiting function of the spleen. Thus the grafting of spleen can be useful and worth doing. Spleen should be transplanted in thin slices since in case of a larger piece they may necrotize and give rise to abscesses.

Animals↗
PubMed1986

Combined use of bioplast and tissue adhesive in experimental nephrectomies in in situ renal hypothermia.

In transvenous regional hypothermia wedge-shaped and flat lower pole resections were made in dogs. The cut surface of the kidney was covered by the combination of tissue adhesive and bioplast without sutures. It was found that the polymerization time of the tissue adhesive almost doubled. The usual rigidity of the adhesive was more expressed than in normothermia and it was not influenced by re-heating. Recovery conditions were more favourable; a larger portion of the parenchyma could be preserved than with the traditional closure with needle and thread.

Animals↗
PubMed1985

Auto-alloplastics closure of cervical esophageal fistulae.

The authors performed auto-alloplastic replacement with flap through a round incision, 20 to 22 in mm diameter, to elaborate a suitable method for closing the fistulae which may from during cervical esophageal operations. Of the animals three died due to other causes, the others could be evaluated, and, although the operated esophagus had not been relieved from inner pressure, after 24 hours the animals were capable of drinking, later eating. The auto-alloplastic flap was followed up by histological examination for six months.

Animals↗
PubMed1985

Experimental in situ renal hypothermia through the renal vein.

The authors worked out the technique of in situ renal hypothermia in dogs by direct cannulation of the renal vein or through the internal spermatic vein (ovarian vein). The technique is suggested for preventing the ischaemic impairment of the renal parenchyma in operations requiring compression of the renal artery for more than 20 minutes.

Animals↗
PubMed1984

Experimental study of suture materials placed in the renal parenchyma.

Absorbable and non-absorbable suture materials in the renal parenchyma were examined in comparative studies performed on 12 mongrel dogs. Quantitative and qualitative histological studies showed that Dexon was preferable to other absorbable suture materials as opposed to traditional catgut, while Supramide and Polyester had certain advantages over other non-absorbable materials.

Absorption↗
PubMed1983

The role of ischaemia in the formation of postoperative intra-abdominal adhesions.

The formation of intra-abdominal adhesions was studied in animal experiments. In dogs, the peritoneal lining was eliminated on the left side of the abdominal wall, while ischaemia was elicited contralaterally by suturing the main vessels. Two to seven weeks later no omental adhesion could be found on the abdominal wall deprived of peritoneum, while it developed in 11 of the 13 operated animals in the ischaemic area.

Abdominal Muscles↗
PubMed1983

Sutures inserted into the gastric wall an experimental study.

Thirty gastrotomies were performed in 15 dogs using 2/0 atraumatic needles. Various kinds of threads were used: Dexon as an absorbable suture, Black Perlon and Black Braided Silk as nonabsorbable sutures. Ten suture rows were made with each material. Single-row interrupted sutures were made with no suture in the mucosa. No suture insufficiency occurred. Dexon proved to be the most suitable material, although the nonabsorbable sutures did not cause complications, either.

Animals↗
PubMed1983

Comparative studies with extracorporeal hypothermal kidney perfusion.

Various solutions of extra- and intracellular, or non-electrolyte type supplemented with papaverine or lidocaine were administered by gravity perfusion to 60 dog kidneys. Cooling in the kidneys perfused with the solutions containing papaverine lowered the temperature of kidneys in significantly shorter time than in those containing lidocaine. The histological examinations revealed good perfusion with solutions containing papaverine; even the rim of the cortical substance has been freed of blood. Identical results could not be achieved with lidocaine. These results are to be considered in the clinical work.

Animals↗