Biomedical subjects
I Melamed
Publications and source records attributed to I Melamed.
March myoglobinemia: a hazard to renal function.
Serum muscle enzyme levels, myoglobin levels, and renal function were measured in a group of 20 army recruits who had volunteered for a prolonged period of primary, specially designed, gradual training. Blood samples were taken before training and before and after each hike. Levels of serum myoglobin, creatinine phosphokinase, lactic dehydrogenase, and SGOT indicated muscle injury. Levels of urea creatinine, and uric acid and creatinine clearance evaluated renal function. Substantial elevation of muscle enzyme levels and persistent myoglobinemia were observed throughout the study. A highly significant decrease in creatinine clearance was demonstrated. After the last hike, the mean creatinine clearance was 70.41 mL/min, which is notably lower than the value at the beginning of the study. Prolonged physical exercise induces muscular damage, as evidenced by a rise in myoglobin and enzyme levels. Continuous muscle injury induces persistent myoglobinemia, a probable hazard to renal function.
Suppressor T cell activity in splenectomized subjects.
The effect of splenectomy on the expression of suppressor activity of peripheral blood lymphocytes was examined in this study. 63 soldiers splenectomized for trauma or hematological diseases one to 24 years earlier, were studied by measuring the suppressor cell activity (using the Con A method), and lymphocyte blast transformation in response to lectines (PHA, Con A, PWM). There was a decrease in suppressor cell activity in 15 (23.8%) of the splenectomized patients. This decrease was greater in subjects splenectomized for trauma than in those splenectomized electively (24% and 22% respectively). The decrease was related to length to time from surgery being highest in the first 5 years after removal of the spleen and was more frequent in females (43%). The mean of the stimulation indices calculated from the mitogenic response to PHA, PWM and Con A was lower in the splenectomized patients with reduced suppressor activity than in those with normal suppressor activity. The findings of our present study supports the view that splenectomy interferes with normal immunoregulatory mechanisms and suggests that pyogenic infections are not the sole hazard of this procedure.
Histamine content in human kidneys with hypernephroid carcinoma. Is there a pathophysiological mechanism?
The hypernephroid carcinoma is the most common tumour of the kidney in adults. Haematuria can occur, even in the early developmental stages. In investigations of 30 patients with-haematuria, radiological examinations were made and the plasma histamine levels were determined in both from the renal artery and vein, the vena cava and the aorta. After nephrectomy, the histamine content of various tissues in different regions of the kidney were investigated. Significant increases of plasma and tissue histamine levels were found in the veins of the tumour-riddled kidney and in the tissue surrounding the tumour. an experimental study on dogs investigated whether or not an injection of histamine into the renal artery would provoke haematuria. Dose-dependent haematuria occurred, which was most pronounced following intra-arterial injection of 25 micrograms/kg of histamine.
Kawasaki disease with serological evidence of streptococcal infection.
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