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Biomedical subjects

I Mechlenburg

Publications and source records attributed to I Mechlenburg.

2 recordsLinked to original sources

Cartilage thickness in the hip joint measured by MRI and stereology--a methodological study.

OBJECTIVE: The purpose of this study was to develop a precise and efficient method for estimating the thickness of the articular cartilage in the hip joint and hence three different stereologic methods were tested based on Magnetic Resonance Imaging. DESIGN: Twenty two females and four males with hip dysplasia underwent MRI. The thickness of the femoral and acetabular cartilage was estimated. RESULTS: The results for all three methods showed that the observed total variance on cartilage thickness is small. The mean thickness of the acetabular cartilage measured by the three different methods ranged between 1.15 mm and 1.46 mm. The mean thickness for the femoral cartilage measured by the three different methods ranged between 1.18 mm and 1.78 mm. The measurements took 15-20 min per hip to carry out. CONCLUSION: Methods 1 and 3 are as precise but we favour method 3 because the measurements are done on images obtained through the center of the femoral head which means that the cartilage surface is intersected perpendicular and partial volume effect avoided. We suggest that this method can be advantageous for assessing the progression of osteoarthritis in dysplastic hips after periacetabular osteotomy.

Adult↗

Prospective bone density changes after periacetabular osteotomy: a methodological study.

We used computed tomography (CT) and 3D design-based sampling principles (stereology) to estimate changes in acetabular bone density after periacetabular osteotomy. We included six consecutive patients with hip dysplasia in the study. Baseline density was measured within the first 7 days following periacetabular osteotomy and compared with bone density 2 years later. Double measurements were performed on three patients, and the coefficient of error of the mean was estimated to 0.05. Bone density in zone 1 increased significantly in the anteromedial quadrant as well as in the posteromedial quadrant of the acetabulum. In the anterolateral and the posterolateral quadrant, bone density was unchanged. In zone 2 and 3, bone density was unchanged 2 years postoperatively. We suggest that the observed increase in bone density medially represents a remodelling response to an altered load distribution after osteotomy. The method used is a precise tool to estimate changes in acetabular bone density.

Acetabulum↗